Epstein-Barr virus encephalitis presenting with a tumor-like lesion in an immunosuppressed transplant recipient.


:Epstein-Barr virus (EBV) associated central nervous system (CNS) infection is a rare disease. We report an atypical manifestation of EBV encephalitis initially presenting with a tumor-like lesion of the optic tract in an immunocompromised patient 8 years after a combined kidney and pancreas transplantation had been performed. Polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF) and antibody testing confirmed the diagnosis of EBV encephalitis, most likely as a consequence of a reactivated persistent EBV infection. After cessation of the immunosuppressive therapy and induction of treatment with ganciclovir, clinical and magnetic resonance imaging (MRI) findings rapidly improved.


J Neurovirol


Journal of neurovirology


Khalil M,Enzinger C,Wallner-Blazek M,Scarpatetti M,Barth A,Horn S,Reiter G




Has Abstract


2008-11-01 00:00:00














  • Cognitive behavioural impairment with irreversible sensorineural deafness as a complication of West Nile encephalitis.

    abstract::Despite common clinical features to suggest encephalitis, different viral encephalitides are known to have some specific clinical features, which if present, may suggest infection by a particular virus. West Nile viral (WNV) encephalitis has not been described with any specific diagnostic feature so far. In this conte...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Pradhan S,Anand S,Choudhury SS

    更新日期:2019-06-01 00:00:00

  • HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter.

    abstract::Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,多中心研究


    authors: Keltner JR,Fennema-Notestine C,Vaida F,Wang D,Franklin DR,Dworkin RH,Sanders C,McCutchan JA,Archibald SL,Miller DJ,Kesidis G,Cushman C,Kim SM,Abramson I,Taylor MJ,Theilmann RJ,Julaton MD,Notestine RJ,Corkran S,Chern

    更新日期:2014-06-01 00:00:00

  • Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59.

    abstract::Murine hepatitis virus A59 infection of the central nervous system (CNS) results in CNS demyelination in susceptible strains of mice. In infected B-cell-deficient mice, demyelination not only occurred but was also more severe than in parental C57BL/6 animals. This increase may be due to the persistence of virus in the...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Matthews AE,Lavi E,Weiss SR,Paterson Y

    更新日期:2002-06-01 00:00:00

  • Neural dysregulation during a working memory task in human immunodeficiency virus-seropositive and hepatitis C coinfected individuals.

    abstract::Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

    更新日期:2014-08-01 00:00:00

  • Alterations in blood-brain barrier glucose transport in SIV-infected macaques.

    abstract::The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Mankowski JL,Queen SE,Kirstein LM,Spelman JP,Laterra J,Simpson IA,Adams RJ,Clements JE,Zink MC

    更新日期:1999-12-01 00:00:00

  • Cognitive functioning during highly active antiretroviral therapy interruption in human immunodeficiency virus type 1 infection.

    abstract::Although no longer considered therapeutically beneficial, antiretroviral treatment interruptions (TIs) still occur frequently among patients with human immunodeficiency virus (HIV) infection for a variety of reasons. TIs typically result in viral rebound and worsening immunosuppression, which in turn are risk factors ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Childers ME,Woods SP,Letendre S,McCutchan JA,Rosario D,Grant I,Mindt MR,Ellis RJ,San Diego HIV Neurobehavioral Research Center Group.

    更新日期:2008-11-01 00:00:00

  • Murine hepatitis virus--a model for virus-induced CNS demyelination.

    abstract::Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Matthews AE,Weiss SR,Paterson Y

    更新日期:2002-04-01 00:00:00

  • A mechanism for selective induction of 2'-5' oligoadenylate synthetase, anti-viral state, but not MHC class I genes by interferon-beta in neurons.

    abstract::Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral inf...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Massa PT,Whitney LW,Wu C,Ropka SL,Jarosinski KW

    更新日期:1999-04-01 00:00:00

  • Human immunodeficiency virus type 1 Tat modulates proliferation and differentiation of human neural precursor cells: implication in NeuroAIDS.

    abstract::Human immunodeficiency virus type 1 (HIV-1) and viral proteins affect neuronal survival and neuron-glial cell interactions, which culminate in neurological disorders. HIV-1 infects regions of neurogenesis in human adult and pediatric brain. However, little is known about the effect of HIV-1 or viral proteins on the pr...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Mishra M,Taneja M,Malik S,Khalique H,Seth P

    更新日期:2010-10-01 00:00:00

  • Expression of miR-155 associated with Toll-like receptors 3, 7, and 9 transcription in the olfactory bulbs of cattle naturally infected with BHV5.

    abstract::Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Oliveira BRSM,Vieira FV,de S Vieira D,da Silva SEL,Gameiro R,Flores EF,Cardoso TC

    更新日期:2017-10-01 00:00:00

  • Interruptions of antiretroviral therapy in human immunodeficiency virus infection: are they detrimental to neurocognitive functioning?

    abstract::Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study was carried out, comparing HIV-infected persons who had interrupted antiretroviral therapy in the pa...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Muñoz-Moreno JA,Fumaz CR,Prats A,Ferrer MJ,Negredo E,Pérez-Alvarez N,Moltó J,Gómez G,Garolera M,Clotet B

    更新日期:2010-05-01 00:00:00

  • Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies.

    abstract::Recent reports suggest that a growing number of human immunodeficiency virus (HIV)-infected persons show signs of persistent cognitive impairment even in the context of combination antiretroviral therapies (cART). The basis for this finding remains poorly understood as there are only a limited number of studies examin...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,多中心研究


    authors: Tate DF,Sampat M,Harezlak J,Fiecas M,Hogan J,Dewey J,McCaffrey D,Branson D,Russell T,Conley J,Taylor M,Schifitto G,Zhong J,Daar ES,Alger J,Brown M,Singer E,Campbell T,McMahon D,Tso Y,Matesan J,Letendre S,Paulo

    更新日期:2011-08-01 00:00:00

  • Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy.

    abstract::Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part o...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,随机对照试验


    authors: Shikuma CM,Bennett K,Ananworanich J,Gerschenson M,Teeratakulpisarn N,Jadwattanakul T,DeGruttola V,McArthur JC,Ebenezer G,Chomchey N,Praihirunkit P,Hongchookiat P,Mathajittiphun P,Nakamoto B,Hauer P,Phanuphak P,Phanuphak N

    更新日期:2015-10-01 00:00:00

  • NTPDase and 5'-nucleotidase activities in synaptosomes of rabbits experimentally infected with BoHV-5.

    abstract::Bovine herpesvirus type 5 (BoHV-5) is the causative agent of herpetic meningoencephalitis in cattle. The purinergic system is described as a modulator of the immune response and neuroinflammation. These functions are related to the extracellular nucleotides concentration. NTPDase and 5'-nucleotidase are enzymes respon...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: da Silva CB,Paim FC,Wolkmer P,Abdalla FH,Carvalho FB,Palma HH,Mello CB,Flores EF,Andrade CM,Lopes ST

    更新日期:2015-10-01 00:00:00

  • CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex.

    abstract::AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Bjugstad KB,Flitter WD,Garland WA,Philpot RM,Kirstein CL,Arendash GW

    更新日期:2000-12-01 00:00:00

  • HTLV-1 proviral load in cerebrospinal fluid may not be a good marker to differentiate asymptomatic carriers with high proviral load in blood from HAM/TSP patients.

    abstract::An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Martins ML,de Freitas Carneiro-Proietti AB,Nicolato R,de Miranda DM,Romanelli LCF

    更新日期:2018-08-01 00:00:00

  • Relationship between brain large artery characteristics and their downstream arterioles.

    abstract::We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Gutierrez J,Murray J,Chon C,Morgello S

    更新日期:2018-02-01 00:00:00

  • Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.

    abstract::Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

    更新日期:1995-03-01 00:00:00

  • Cocaine-mediated enhancement of virus replication in macrophages: implications for human immunodeficiency virus-associated dementia.

    abstract::Injection drug use has been recognized as a major risk factor for acquired immunodeficiency syndrome (AIDS) from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States, can both impair the functions of macrophages and CD4(+) lymphocytes and also activate human immunodeficiency vi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Dhillon NK,Williams R,Peng F,Tsai YJ,Dhillon S,Nicolay B,Gadgil M,Kumar A,Buch SJ

    更新日期:2007-12-01 00:00:00

  • Giant cell encephalitis and microglial infection with mucosally transmitted simian-human immunodeficiency virus SHIVSF162P3N in rhesus macaques.

    abstract::Neurocognitive disorders such as dementia and cognitive/motor impairments are among the most significant complications associated with human immunodeficiency virus (HIV) infection, especially in aging populations, yet the pathogenesis remains poorly understood. Activated macrophages and microglia in white matter along...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Harbison C,Zhuang K,Gettie A,Blanchard J,Knight H,Didier P,Cheng-Mayer C,Westmoreland S

    更新日期:2014-02-01 00:00:00

  • Localization of sequences within the latency-related gene of bovine herpesvirus 1 that inhibit mammalian cell growth.

    abstract::The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Geiser V,Jones C

    更新日期:2005-12-01 00:00:00

  • Varicella-zoster virus human ganglionic latency: a current summary.

    abstract::Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Kennedy PG,Cohrs RJ

    更新日期:2010-11-01 00:00:00

  • Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis.

    abstract::Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is an inflammatory disease of the spinal cord and clinically characterized by progressive spastic paraparesis, urinary incontinence, and mild sen...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Nozuma S,Kubota R,Jacobson S

    更新日期:2020-10-01 00:00:00

  • Progressive multifocal leukoencephalopathy in Zambia is caused by JC virus with prototype regulatory region.

    abstract::There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Mubanga E,Patel A,Siddiqi OK,Hanson BA,Dang X,Lakhi S,Mulundu G,Bender N,Koralnik IJ

    更新日期:2019-08-01 00:00:00

  • MRI of spinal cord in MS.

    abstract::Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Bastianello S,Paolillo A,Giugni E,Giuliani S,Evangelisti G,Luccichenti G,Angeloni U,Colonnese C,Salvetti M,Gasperini C,Pozzilli C,Fieschi C

    更新日期:2000-05-01 00:00:00

  • Genotyping of human parechoviruses in Iranian young children with aseptic meningitis and sepsis-like illness.

    abstract::Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Rahimi P,Naser HM,Siadat SD,Sohrabi A,Mostafavi E,Motamedirad M,Bahramali G,Sadat SM,Ardestani MS

    更新日期:2013-12-01 00:00:00

  • Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease.

    abstract::Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Paul RH,Joska JA,Woods C,Seedat S,Engelbrecht S,Hoare J,Heaps J,Valcour V,Ances B,Baker LM,Salminen LE,Stein DJ

    更新日期:2014-12-01 00:00:00

  • HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research.

    abstract::Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Churchill MJ,Cowley DJ,Wesselingh SL,Gorry PR,Gray LR

    更新日期:2015-06-01 00:00:00

  • The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT).

    abstract::The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Carpenter D,Hsiang C,Jiang X,Osorio N,BenMohamed L,Jones C,Wechsler SL

    更新日期:2015-10-01 00:00:00

  • Effort and neuropsychological performance in HIV-infected individuals on stable combination antiretroviral therapy.

    abstract::The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Paul R,Rhee G,Baker LM,Vaida F,Cooley SA,Ances BM

    更新日期:2017-10-01 00:00:00