Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals.

Abstract:

:Chemokines influence HIV neuropathogenesis by affecting the HIV life cycle, trafficking of macrophages into the nervous system, glial activation, and neuronal signaling and repair processes; however, knowledge of their relationship to in vivo measures of cerebral injury is limited. The primary objective of this study was to determine the relationship between a panel of chemokines in cerebrospinal fluid (CSF) and cerebral metabolites measured by proton magnetic resonance spectroscopy (MRS) in a cohort of HIV-infected individuals. One hundred seventy-one stored CSF specimens were assayed from HIV-infected individuals who were enrolled in two ACTG studies that evaluated the relationship between neuropsychological performance and cerebral metabolites. Concentrations of six chemokines (fractalkine, IL-8, IP-10, MCP-1, MIP-1β, and SDF-1) were measured and compared with cerebral metabolites individually and as composite neuronal, basal ganglia, and inflammatory patterns. IP-10 and MCP-1 were the chemokines most strongly associated with individual cerebral metabolites. Specifically, (1) higher IP-10 levels correlated with lower N-acetyl aspartate (NAA)/creatine (Cr) ratios in the frontal white matter and higher MI/Cr ratios in all three brain regions considered and (2) higher MCP-1 levels correlated with lower NAA/Cr ratios in frontal white matter and the parietal cortex. IP-10, MCP-1, and IL-8 had the strongest associations with patterns of cerebral metabolites. In particular, higher levels of IP-10 correlated with lower neuronal pattern scores and higher basal ganglia and inflammatory pattern scores, the same pattern which has been associated with HIV-associated neurocognitive disorders (HAND). Subgroup analysis indicated that the effects of IP-10 and IL-8 were influenced by effective antiretroviral therapy and that memantine treatment may mitigate the neuronal effects of IP-10. This study supports the role of chemokines in HAND and the validity of MRS as an assessment tool. In particular, the findings identify relationships between the immune response-particularly an interferon-inducible chemokine, IP-10-and cerebral metabolites and suggest that antiretroviral therapy and memantine modify the impact of the immune response on neurons.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Letendre SL,Zheng JC,Kaul M,Yiannoutsos CT,Ellis RJ,Taylor MJ,Marquie-Beck J,Navia B,HIV Neuroimaging Consortium.

doi

10.1007/s13365-010-0013-2

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

63-9

issue

1

eissn

1355-0284

issn

1538-2443

journal_volume

17

pub_type

杂志文章
  • Neural dysregulation during a working memory task in human immunodeficiency virus-seropositive and hepatitis C coinfected individuals.

    abstract::Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0257-3

    authors: Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

    更新日期:2014-08-01 00:00:00

  • Ganciclovir-resistant cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient.

    abstract::We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and b...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550281003682539

    authors: Arslan F,Tabak F,Avşar E,Midilli K,Mert A,Ozaras R,Soysal T,Ozturk R,Ferhanoglu B

    更新日期:2010-03-01 00:00:00

  • Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals.

    abstract::Human immunodeficiency virus (HIV) dementia remains as an important cause of neurological morbidity among HIV-seropositive (HIV+) individuals. Differences in the neuropsychological profiles between older and younger HIV+ individuals have not been examined extensively. The objective of this study was to examine the neu...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280701258423

    authors: Sacktor N,Skolasky R,Selnes OA,Watters M,Poff P,Shiramizu B,Shikuma C,Valcour V

    更新日期:2007-06-01 00:00:00

  • Clinical features and preliminary studies of virological correlates of neurocognitive impairment among HIV-infected individuals in Nigeria.

    abstract::In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-012-0097-y

    authors: Royal W 3rd,Cherner M,Carr J,Habib AG,Akomolafe A,Abimiku A,Charurat M,Farley J,Oluyemisi A,Mamadu I,Johnson J,Ellis R,McCutchan JA,Grant I,Blattner WA

    更新日期:2012-06-01 00:00:00

  • Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associa

    abstract::HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0279-x

    authors: Ndhlovu LC,Umaki T,Chew GM,Chow DC,Agsalda M,Kallianpur KJ,Paul R,Zhang G,Ho E,Hanks N,Nakamoto B,Shiramizu BT,Shikuma CM

    更新日期:2014-12-01 00:00:00

  • Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis.

    abstract::Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is an inflammatory disease of the spinal cord and clinically characterized by progressive spastic paraparesis, urinary incontinence, and mild sen...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-020-00881-w

    authors: Nozuma S,Kubota R,Jacobson S

    更新日期:2020-10-01 00:00:00

  • Effort and neuropsychological performance in HIV-infected individuals on stable combination antiretroviral therapy.

    abstract::The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-017-0557-5

    authors: Paul R,Rhee G,Baker LM,Vaida F,Cooley SA,Ances BM

    更新日期:2017-10-01 00:00:00

  • Defining the roles for Vpr in HIV-1-associated neuropathogenesis.

    abstract::It is increasingly evident that the human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has a unique role in neuropathogenesis. Its ability to induce G2/M arrest coupled with its capacity to increase viral gene transcription gives it a unique role in sustaining viral replication and aiding in the establi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-016-0436-5

    authors: James T,Nonnemacher MR,Wigdahl B,Krebs FC

    更新日期:2016-08-01 00:00:00

  • The herpes simplex virus type 1 early gene (thymidine kinase) promoter is activated in neurons of brain, but not trigeminal ganglia, of transgenic mice in the absence of viral proteins.

    abstract::Latent infection of sensory neurons and reactivation are necessary for maintenance of herpes simplex virus type 1 (HSV-1) in its host population. It has been proposed that the HSV-1 early gene, thymidine kinase (TK), may play an important regulatory role in this process. The authors used reporter transgenic mice to te...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490279771

    authors: Loiacono CM,Myers R,Mitchell WJ

    更新日期:2004-04-01 00:00:00

  • Neuroleptic malignant syndrome as a presenting feature of subacute sclerosing panencephalitis.

    abstract::Subacute sclerosing panencephalitis (SSPE) is a slowly progressive degenerative disorder caused by measles virus. It is characterised by typical clinical and electrophysiological features in the form of slow myoclonic jerks, with progressive cognitive impairment, visual symptoms, and periodic complexes on EEG, with ra...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-017-0602-4

    authors: Garg D,Reddy V,Singh RK,Dash D,Bhatia R,Tripathi M

    更新日期:2018-02-01 00:00:00

  • Initiation of antiretroviral therapy after the critical neuronal developmental period of the second postnatal year affects white matter microstructure in adolescents living with HIV.

    abstract::Rapid maturation of major white matter pathways occurs in the first 2 years of life, indicating a critical neuronal developmental period. The impact of initiating antiretroviral therapy (ART) in children perinatally infected with HIV-1, after the age of 2 years on neurocognitive functioning and white matter developmen...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-018-0712-7

    authors: Hoare J,Heany SJ,Fouche JP,Phillips N,Joska JA,Myer L,Zar HJ,Stein DJ

    更新日期:2019-04-01 00:00:00

  • Cidofovir in AIDS-associated progressive multifocal leukoencephalopathy: a monocenter observational study with clinical and JC virus load monitoring.

    abstract::A monocenter observational study was conducted to determine the clinical and virological effects of cidofovir added to highly active anti-retroviral therapy (HAART) in AIDS-associated progressive multifocal leukoencephalopathy (PML). Exposure to other anti-viral drugs or late initiation of cidofovir were exclusion cri...

    journal_title:Journal of neurovirology

    pub_type: 临床试验,杂志文章

    doi:10.1080/13550280152537274

    authors: Gasnault J,Kousignian P,Kahraman M,Rahoiljaon J,Matheron S,Delfraissy JF,Taoufik Y

    更新日期:2001-08-01 00:00:00

  • NTPDase and 5'-nucleotidase activities in synaptosomes of rabbits experimentally infected with BoHV-5.

    abstract::Bovine herpesvirus type 5 (BoHV-5) is the causative agent of herpetic meningoencephalitis in cattle. The purinergic system is described as a modulator of the immune response and neuroinflammation. These functions are related to the extracellular nucleotides concentration. NTPDase and 5'-nucleotidase are enzymes respon...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0349-8

    authors: da Silva CB,Paim FC,Wolkmer P,Abdalla FH,Carvalho FB,Palma HH,Mello CB,Flores EF,Andrade CM,Lopes ST

    更新日期:2015-10-01 00:00:00

  • Trail Making Test A improves performance characteristics of the International HIV Dementia Scale to identify symptomatic HAND.

    abstract::Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-013-0151-4

    authors: Chalermchai T,Valcour V,Sithinamsuwan P,Pinyakorn S,Clifford D,Paul RH,Tipsuk S,Fletcher JL,Degruttola V,Ratto-Kim S,Hutchings N,Shikuma C,Ananworanich J,SEARCH 007 and 011 study groups.

    更新日期:2013-04-01 00:00:00

  • Analysis of the expression directed by two HTLV-I promoters in transgenic mice.

    abstract::We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289609146898

    authors: Coscoy L,Gonzalez-Dunia D,Chirinian-Swan S,Brahic M,Ozden S

    更新日期:1996-10-01 00:00:00

  • Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study.

    abstract::HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-012-0135-9

    authors: Zhu T,Zhong J,Hu R,Tivarus M,Ekholm S,Harezlak J,Ombao H,Navia B,Cohen R,Schifitto G

    更新日期:2013-02-01 00:00:00

  • The cellular response to herpes simplex virus type 1 (HSV-1) during latency and reactivation.

    abstract::In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280591002405

    authors: Kent JR,Fraser NW

    更新日期:2005-08-01 00:00:00

  • Molecular analysis of JC virus genotypes circulating among the Italian healthy population.

    abstract::JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280390241269

    authors: Pagani E,Delbue S,Mancuso R,Borghi E,Tarantini L,Ferrante P

    更新日期:2003-10-01 00:00:00

  • Risk factors for human immunodeficiency virus type-1 acquisition in women in Africa.

    abstract::Over 65% of individuals infected with human immunodeficiency virus type 1 (HIV-1) reside in sub-Saharan Africa, and thus efforts to change the course of the HIV-1 pandemic should focus on this geographic region. Here, we discuss factors, including sexually transmitted diseases and hormonal contraceptive use, that impa...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:

    authors: Benki S,McClelland RS,Overbaugh J

    更新日期:2005-01-01 00:00:00

  • Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies.

    abstract::Recent reports suggest that a growing number of human immunodeficiency virus (HIV)-infected persons show signs of persistent cognitive impairment even in the context of combination antiretroviral therapies (cART). The basis for this finding remains poorly understood as there are only a limited number of studies examin...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s13365-011-0033-6

    authors: Tate DF,Sampat M,Harezlak J,Fiecas M,Hogan J,Dewey J,McCaffrey D,Branson D,Russell T,Conley J,Taylor M,Schifitto G,Zhong J,Daar ES,Alger J,Brown M,Singer E,Campbell T,McMahon D,Tso Y,Matesan J,Letendre S,Paulo

    更新日期:2011-08-01 00:00:00

  • Restricted replication of herpes simplex virus in satellite glial cell cultures clonally derived from adult mice.

    abstract::To determine the possible influence of satellite glial cells on restricting the spread of herpes simplex virus in the peripheral nervous system, HSV replication was studied in clonally derived cultures of satellite glial cells from adult animals. Satellite cells were purified by exploiting their close anatomical assoc...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909029479

    authors: Wilkinson R,Leaver C,Simmons A,Pereira RA

    更新日期:1999-08-01 00:00:00

  • Varicella-zoster virus human ganglionic latency: a current summary.

    abstract::Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/BF03210846

    authors: Kennedy PG,Cohrs RJ

    更新日期:2010-11-01 00:00:00

  • Relationship between brain large artery characteristics and their downstream arterioles.

    abstract::We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-017-0606-0

    authors: Gutierrez J,Murray J,Chon C,Morgello S

    更新日期:2018-02-01 00:00:00

  • Long-term virological effect of highly active antiretroviral therapy on cerebrospinal fluid and relationship with genotypic resistance.

    abstract::The objective of this study was to assess the long-term virological response in cerebrospinal fluid (CSF) in patients treated with highly active antiretroviral therapy (HAART) and to compare this response to CSF and plasma human immunodeficiency virus (HIV) drug resistance profiles. Paired CSF and plasma specimens wer...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/753312753

    authors: Bestetti A,Presi S,Pierotti C,Bossolasco S,Sala S,Racca S,Carrera P,Lazzarin A,Cinque P

    更新日期:2004-01-01 00:00:00

  • MRI of spinal cord in MS.

    abstract::Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:

    authors: Bastianello S,Paolillo A,Giugni E,Giuliani S,Evangelisti G,Luccichenti G,Angeloni U,Colonnese C,Salvetti M,Gasperini C,Pozzilli C,Fieschi C

    更新日期:2000-05-01 00:00:00

  • Decreased MEG beta oscillations in HIV-infected older adults during the resting state.

    abstract::The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-013-0220-8

    authors: Becker KM,Heinrichs-Graham E,Fox HS,Robertson KR,Sandkovsky U,O'Neill J,Swindells S,Wilson TW

    更新日期:2013-12-01 00:00:00

  • A pilot study on the antibodies to HHV-6 variants and HHV-7 in CSF of MS patients.

    abstract::In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909045382

    authors: Ongrádi J,Rajda C,Maródi CL,Csiszár A,Vecsei L

    更新日期:1999-10-01 00:00:00

  • Alterations in blood-brain barrier glucose transport in SIV-infected macaques.

    abstract::The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909021298

    authors: Mankowski JL,Queen SE,Kirstein LM,Spelman JP,Laterra J,Simpson IA,Adams RJ,Clements JE,Zink MC

    更新日期:1999-12-01 00:00:00

  • Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.

    abstract::Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289509111008

    authors: Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

    更新日期:1995-03-01 00:00:00

  • High-dose corticosteroids for acute cytomegalovirus-associated transverse myelitis in the immunocompetent patient: a case report and systematic review.

    abstract::We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-018-0717-2

    authors: Budhram A,Liu Y,Krawczyk M,Chan TLH,Burneo JG,Hosseini-Moghaddam SM,Shoesmith C

    更新日期:2019-06-01 00:00:00