Abstract:
:Rabies is a neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment had severe sequelae. The present study showed that after 48 h of RABV inoculation, mice injected intracerebrally with anti-RABV F (ab')2 plus Bioporter® showed 70% survival compared to the control group, suggesting that transfection of anti-RABV antibodies to the brain may prevent or delay the spread of RABV at an early stage of infection. This result may provide important protocol results in intracellular antibody delivery to prevent the fatal outcome of the disease.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Agostinho WC,Brandão PEdoi
10.1007/s13365-020-00883-8subject
Has Abstractpub_date
2020-10-01 00:00:00pages
764-768issue
5eissn
1355-0284issn
1538-2443pii
10.1007/s13365-020-00883-8journal_volume
26pub_type
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