Abstract：
:The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carriage of the type 4 allele of the apolipoprotein E gene (APOE-epsilon 4), and possibly brain injury. Following the authors' previous studies implicating herpes simplex virus type 1 (HSV1) in brain of APOE-epsilon 4 carriers as a major cause of AD, the authors propose here, on the basis of their and others' recent studies, that not only does HSV1 generate the main components of amyloid plaques and neurofibrillary tangles (NFTs) - beta-amyloid (A beta) and abnormally phosphorylated tau but also, by disrupting autophagy, it prevents degradation of these aberrant proteins, leading to their accumulation and deposition, and eventually to AD.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Itzhaki RF,Cosby SL,Wozniak MAdoi
10.1080/13550280701802543subject
Has Abstractpub_date
2008-01-01 00:00:00pages
1-4issue
1eissn
1355-0284issn
1538-2443pii
790912632journal_volume
14pub_type
杂志文章abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease affecting the central nervous system as a result of reactivation of the John Cunningham (JC) polyomavirus and occurs almost exclusively in immunosuppressed individuals. The disease course of PML is variable but usually progressive and often fa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00899-0
更新日期：2020-12-01 00:00:00
abstract：:Rapid maturation of major white matter pathways occurs in the first 2 years of life, indicating a critical neuronal developmental period. The impact of initiating antiretroviral therapy (ART) in children perinatally infected with HIV-1, after the age of 2 years on neurocognitive functioning and white matter developmen...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0712-7
更新日期：2019-04-01 00:00:00
abstract：:In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280591002405
更新日期：2005-08-01 00:00:00
abstract：:JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390241269
更新日期：2003-10-01 00:00:00
abstract：:Excessive glutamate neurotransmission has been implicated in neuronal injury in many disorders of the central nervous system (CNS), including human immunodeficiency virus (HIV)-associated dementia. Gp120IIIB is a strain of a HIV glycoprotein with specificity for the CXCR4 receptor that induces neuronal apoptosis in in...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280903350598
更新日期：2009-09-01 00:00:00
abstract：:In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-012-0097-y
更新日期：2012-06-01 00:00:00
abstract：:Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280903168131
更新日期：2009-09-01 00:00:00
abstract：:To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280590953825
更新日期：2005-07-01 00:00:00
abstract：:We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289609146898
更新日期：1996-10-01 00:00:00
abstract：:Recent studies on the coreceptor usage of human immunodeficiency virus (HIV) strains associated with acquired immunodeficiency syndrome (AIDS) dementia have shown that both X4 and R5 viruses are involved in the process. The disease is associated with enhanced virus replication and monocyte chemoattractant protein (MCP...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/753312763
更新日期：2004-01-01 00:00:00
abstract：:Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-018-0614-8
更新日期：2018-06-01 00:00:00
abstract：:JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280590900391
更新日期：2005-02-01 00:00:00
abstract：:Bovine herpesvirus type 5 (BoHV-5) is the causative agent of herpetic meningoencephalitis in cattle. The purinergic system is described as a modulator of the immune response and neuroinflammation. These functions are related to the extracellular nucleotides concentration. NTPDase and 5'-nucleotidase are enzymes respon...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0349-8
更新日期：2015-10-01 00:00:00
abstract：:Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289609146542
更新日期：1996-04-01 00:00:00
abstract：:Although highly active antiretroviral therapy (HAART) has reduced the incidence of dementia, a significant proportion of HIV-infected individuals cease therapy because of unacceptable side effects. Further, HAART is not available to the majority of HIV-infected people worldwide. Thus, animal models remain an important...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280290101076
更新日期：2002-12-01 00:00:00
abstract：:The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0557-5
更新日期：2017-10-01 00:00:00
abstract：:Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/135502802317247794
更新日期：2002-02-01 00:00:00
abstract：:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0377-4
更新日期：2016-04-01 00:00:00
abstract：:Recent reports suggest that a growing number of human immunodeficiency virus (HIV)-infected persons show signs of persistent cognitive impairment even in the context of combination antiretroviral therapies (cART). The basis for this finding remains poorly understood as there are only a limited number of studies examin...
journal_title：Journal of neurovirology
pub_type： 杂志文章,多中心研究
doi：10.1007/s13365-011-0033-6
更新日期：2011-08-01 00:00:00
abstract：:Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in people living with HIV. This effect was also observed in the central nervous system with the nowadays uncommon observation of dementias; yet in more recent works milder forms are still reported in 20-30% of optimally treated i...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-020-00874-9
更新日期：2020-10-01 00:00:00
abstract：:The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant virus...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009018301
更新日期：2000-10-01 00:00:00
abstract：:It is increasingly evident that the human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has a unique role in neuropathogenesis. Its ability to induce G2/M arrest coupled with its capacity to increase viral gene transcription gives it a unique role in sustaining viral replication and aiding in the establi...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-016-0436-5
更新日期：2016-08-01 00:00:00
abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...
journal_title：Journal of neurovirology
pub_type：
doi：10.1007/s13365-015-0322-6
更新日期：2015-06-01 00:00:00
abstract：:Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0527-y
更新日期：2017-08-01 00:00:00
abstract：:A neuroinvasive/neuropathogenic SIV variant termed SIVmac182 was previously isolated and characterized (Watry et al, 1994). This neuroinvasive strain was derived from the uncloned strain SIVmac251 through serial animal passage of infected microglia, unlike previously reported neurovirulent strains. Importantly, the vi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809114528
更新日期：1998-06-01 00:00:00
abstract：:Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0293-z
更新日期：2014-12-01 00:00:00
abstract：:Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-013-0221-7
更新日期：2013-12-01 00:00:00
abstract：:Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390173319
更新日期：2003-02-01 00:00:00
abstract：:A number of pathogenic microbes including neuroinvasive viruses, bacteria and parasites are capable of entry into the central nervous system (CNS) and cause a variety of clinical manifestations. The cellular and molecular mechanisms for the CNS invasion have been extensively studied in the last two decades. Viruses in...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909021288
更新日期：1999-12-01 00:00:00
abstract：:We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0717-2
更新日期：2019-06-01 00:00:00
