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Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays.

Abstract：

:To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the controls. By a quantitative reverse transcriptase-polymerase chain reaction, the mRNA levels of granulysin were decreased in 30 SSPE patients, and were increased in 7 measles patients, as compared to the 23 controls. These results imply that granulysin might play a role in the host defense against measles virus and possibly be involved in the pathogenesis or pathophysiology of SSPE.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Takemoto M,Kira R,Kusuhara K,Torisu H,Sakai Y,Hara T

doi

10.1080/13550280590953825

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

299-305

issue

3

eissn

1355-0284

issn

1538-2443

pii

T38L4X2818897347

journal_volume

11

pub_type

杂志文章

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