Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model.

abstract：:Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...

journal_title：Journal of neurovirology

authors： Radbill AE,Reddy AT,Markert JM,Wyss JM,Pike MM,Akella NS,Bharara N,Gillespie GY

更新日期：2007-04-01 00:00:00

abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...

journal_title：Journal of neurovirology

authors： Brew BJ,Robertson K,Wright EJ,Churchill M,Crowe SM,Cysique LA,Deeks S,Garcia JV,Gelman B,Gray LR,Johnson T,Joseph J,Margolis DM,Mankowski JL,Spencer B

更新日期：2015-06-01 00:00:00

abstract：:To verify the possibility of different role of JC virus genotypes in the etiology of progressive multifocal leukoencephalopathy, we analysed several JC virus isolates amplified from AIDS patients with and without progressive multifocal leukoencephalopathy and healthy controls by nucleotide sequencing. Cerebrospinal fl...

journal_title：Journal of neurovirology

authors： Ferrante P,Mediati M,Caldarelli-Stefano R,Losciale L,Mancuso R,Cagni AE,Maserati R

更新日期：2001-02-01 00:00:00

abstract：:Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika...

journal_title：Journal of neurovirology

authors： Koppolu V,Shantha Raju T

更新日期：2018-06-01 00:00:00

abstract：:Recent reports suggest that a growing number of human immunodeficiency virus (HIV)-infected persons show signs of persistent cognitive impairment even in the context of combination antiretroviral therapies (cART). The basis for this finding remains poorly understood as there are only a limited number of studies examin...

journal_title：Journal of neurovirology

authors： Tate DF,Sampat M,Harezlak J,Fiecas M,Hogan J,Dewey J,McCaffrey D,Branson D,Russell T,Conley J,Taylor M,Schifitto G,Zhong J,Daar ES,Alger J,Brown M,Singer E,Campbell T,McMahon D,Tso Y,Matesan J,Letendre S,Paulo

更新日期：2011-08-01 00:00:00

abstract：:Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the s...

journal_title：Journal of neurovirology

authors： Coughlin JM,Wang Y,Ma S,Yue C,Kim PK,Adams AV,Roosa HV,Gage KL,Stathis M,Rais R,Rojas C,McGlothan JL,Watkins CC,Sacktor N,Guilarte TR,Zhou Y,Sawa A,Slusher BS,Caffo B,Kassiou M,Endres CJ,Pomper MG

更新日期：2014-06-01 00:00:00

abstract：:The latency-associated transcript (LAT) is the only herpes simplex virus type 1 (HSV-1) gene that is abundantly transcribed during latency. Plasmids expressing LAT inhibit apoptosis induced by etoposide and ceramide in transiently transfected cells. LAT also inhibits apoptosis in trigeminal ganglia of rabbits and prom...

journal_title：Journal of neurovirology

authors： Henderson G,Peng W,Jin L,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2002-12-01 00:00:00

abstract：:HIV viral proteins within the central nervous system are associated with the development of neurocognitive impairments in HIV-infected individuals. Dopamine transporter (DAT)-mediated dopamine transport is critical for normal dopamine homeostasis. Abnormal dopaminergic transmission has been implicated as a risk determ...

journal_title：Journal of neurovirology

authors： Zhu J,Yuan Y,Midde NM,Gomez AM,Sun WL,Quizon PM,Zhan CG

更新日期：2016-06-01 00:00:00

abstract：:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...

journal_title：Journal of neurovirology

authors： Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

更新日期：2016-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) and viral proteins affect neuronal survival and neuron-glial cell interactions, which culminate in neurological disorders. HIV-1 infects regions of neurogenesis in human adult and pediatric brain. However, little is known about the effect of HIV-1 or viral proteins on the pr...

journal_title：Journal of neurovirology

authors： Mishra M,Taneja M,Malik S,Khalique H,Seth P

更新日期：2010-10-01 00:00:00

abstract：:Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection. The appearance of viral RNA is particularly prominent in the cerebrospinal fluid (CSF), suggesting an efficient route of virus transfer across the blood-CSF...

journal_title：Journal of neurovirology

authors： Liu P,Hudson LC,Tompkins MB,Vahlenkamp TW,Colby B,Rundle C,Meeker RB

更新日期：2006-08-01 00:00:00

abstract：:With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of...

journal_title：Journal of neurovirology

authors： Mondal R,Ganguly U,Deb S,Shome G,Pramanik S,Bandyopadhyay D,Lahiri D

更新日期：2020-12-26 00:00:00

abstract：:Murine hepatitis virus A59 infection of the central nervous system (CNS) results in CNS demyelination in susceptible strains of mice. In infected B-cell-deficient mice, demyelination not only occurred but was also more severe than in parental C57BL/6 animals. This increase may be due to the persistence of virus in the...

journal_title：Journal of neurovirology

authors： Matthews AE,Lavi E,Weiss SR,Paterson Y

更新日期：2002-06-01 00:00:00

abstract：:Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...

journal_title：Journal of neurovirology

authors： Du Pasquier RA,Clark KW,Smith PS,Joseph JT,Mazullo JM,De Girolami U,Letvin NL,Koralnik IJ

更新日期：2001-08-01 00:00:00

abstract：:A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an R...

journal_title：Journal of neurovirology

authors： Azizi SA,Azizi SA

更新日期：2020-10-01 00:00:00

abstract：:Chemokines influence HIV neuropathogenesis by affecting the HIV life cycle, trafficking of macrophages into the nervous system, glial activation, and neuronal signaling and repair processes; however, knowledge of their relationship to in vivo measures of cerebral injury is limited. The primary objective of this study ...

journal_title：Journal of neurovirology

authors： Letendre SL,Zheng JC,Kaul M,Yiannoutsos CT,Ellis RJ,Taylor MJ,Marquie-Beck J,Navia B,HIV Neuroimaging Consortium.

更新日期：2011-02-01 00:00:00

abstract：:Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...

journal_title：Journal of neurovirology

authors： Nakamura R,Chong PF,Haraguchi K,Katano H,Tanaka-Taya K,Kira R

更新日期：2020-10-01 00:00:00

abstract：:With aging of HIV populations, there is concern that Alzheimer's disease (AD) may become prevalent and difficult to distinguish from HIV-associated neurocognitive disorders. To date, there are no reports documenting histologically verified Alzheimer's neuropathology in individuals with HIV and dementia. Herein, we rep...

journal_title：Journal of neurovirology

authors： Morgello S,Jacobs M,Murray J,Byrd D,Neibart E,Mintz L,Meloni G,Chon C,Crary J

更新日期：2018-10-01 00:00:00

abstract：:Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...

journal_title：Journal of neurovirology

authors： Weed MR,Hienz RD,Brady JV,Adams RJ,Mankowski JL,Clements JE,Zink MC

更新日期：2003-08-01 00:00:00

abstract：:An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...

journal_title：Journal of neurovirology

authors： Martins ML,de Freitas Carneiro-Proietti AB,Nicolato R,de Miranda DM,Romanelli LCF

更新日期：2018-08-01 00:00:00

abstract：:Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...

journal_title：Journal of neurovirology

authors： Weber T,Frye S,Bodemer M,Otto M,Lüke W

更新日期：1996-06-01 00:00:00

abstract：:Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly...

journal_title：Journal of neurovirology

authors： Oliveira BRSM,Vieira FV,de S Vieira D,da Silva SEL,Gameiro R,Flores EF,Cardoso TC

更新日期：2017-10-01 00:00:00

abstract：:In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...

journal_title：Journal of neurovirology

authors： Kent JR,Fraser NW

更新日期：2005-08-01 00:00:00

abstract：:The recent ability to quantitate and localize the interaction of antigen-specific T cells in the central nervous system during infectious and autoimmune diseases will greatly enhance our understanding of the molecular and biologic basis of virus-induced diseases of the nervous and other systems. ...

journal_title：Journal of neurovirology

authors： Oldstone MB

更新日期：2004-08-01 00:00:00

abstract：:We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for oth...

journal_title：Journal of neurovirology

authors： Crossley KM,Agnihotri S,Chaganti J,Rodriguez ML,McNally LP,Venna N,Turbett SE,Gutman M,Morey A,Koralnik IJ,Brew BJ

更新日期：2016-08-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...

journal_title：Journal of neurovirology

authors： Ndhlovu LC,Umaki T,Chew GM,Chow DC,Agsalda M,Kallianpur KJ,Paul R,Zhang G,Ho E,Hanks N,Nakamoto B,Shiramizu BT,Shikuma CM

更新日期：2014-12-01 00:00:00

abstract：:JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...

journal_title：Journal of neurovirology

authors： Pagani E,Delbue S,Mancuso R,Borghi E,Tarantini L,Ferrante P

更新日期：2003-10-01 00:00:00

abstract：:The last 3 years have seen a dramatic fall in mortality and morbidity from HIV infection. Four factors have contributed to this: an improved understanding of the pathogenesis of HIV infection; the availability of tests that could measure plasma viral burden; the development of new and more powerful drugs such as the p...

journal_title：Journal of neurovirology

authors： Powderly WG

更新日期：2000-05-01 00:00:00

abstract：:Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral inf...

journal_title：Journal of neurovirology

authors： Massa PT,Whitney LW,Wu C,Ropka SL,Jarosinski KW

更新日期：1999-04-01 00:00:00

abstract：:The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...

journal_title：Journal of neurovirology

authors： Richt JA,Alexander RC,Herzog S,Hooper DC,Kean R,Spitsin S,Bechter K,Schüttler R,Feldmann H,Heiske A,Fu ZF,Dietzschold B,Rott R,Koprowski H

更新日期：1997-04-01 00:00:00