Abstract:
:Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multiple directed mutations. Although the safety of G207 has been demonstrated in adults, application of viral oncolytic therapy to children with brain tumors has been delayed because of previous lack of data concerning the impact of a replication-competent oncolytic virus on the developing mammalian brain. In this study there was no significant difference in long-term physical development, cognitive performance, or exploratory behaviors between mice that received intracerebral inoculation of G207 or control saline at 4 days of age. However, histological examination and magnetic resonance imaging revealed frequent unilateral ventriculomegaly ipsilateral to the site of injection in only the G207 group. These results suggest that although it is unlikely that G207 will have significant adverse effects on neurodevelopmental outcomes of pediatric patients with brain tumors, an initial study of G207 in children should exclude those patients with tumors in or near the ventricular system as well as patients less than 2 years of age. Furthermore, patients in such a study will need to be closely monitored for the development of hydrocephalus.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Radbill AE,Reddy AT,Markert JM,Wyss JM,Pike MM,Akella NS,Bharara N,Gillespie GYdoi
10.1080/13550280601187177subject
Has Abstractpub_date
2007-04-01 00:00:00pages
118-29issue
2eissn
1355-0284issn
1538-2443pii
778724292journal_volume
13pub_type
杂志文章abstract::The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...
journal_title:Journal of neurovirology
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doi:10.1007/s13365-015-0361-z
更新日期:2015-10-01 00:00:00
abstract::The combined effects of human immunodeficiency virus (HIV), obesity, and elevated visceral adipose tissue (VAT) on brain structure are unknown. In a cross-sectional analysis of Multicenter AIDS Cohort Study (MACS) participants, we determined associations between HIV serostatus, adiposity, and brain structure. Men (133...
journal_title:Journal of neurovirology
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doi:10.1007/s13365-016-0507-7
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abstract::Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...
journal_title:Journal of neurovirology
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doi:10.1080/13550280802074539
更新日期:2008-08-01 00:00:00
abstract::Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title:Journal of neurovirology
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doi:10.1007/s13365-014-0293-z
更新日期:2014-12-01 00:00:00
abstract::Over 65% of individuals infected with human immunodeficiency virus type 1 (HIV-1) reside in sub-Saharan Africa, and thus efforts to change the course of the HIV-1 pandemic should focus on this geographic region. Here, we discuss factors, including sexually transmitted diseases and hormonal contraceptive use, that impa...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient c...
journal_title:Journal of neurovirology
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doi:10.1007/s13365-016-0503-y
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abstract::Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0271-5
更新日期:2015-06-01 00:00:00
abstract::Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivati...
journal_title:Journal of neurovirology
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doi:10.1007/s13365-017-0534-z
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abstract::Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290049534
更新日期:2002-04-01 00:00:00
abstract::When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490261716
更新日期:2004-02-01 00:00:00
abstract::Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802105002
更新日期:2008-05-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1)-associated neuropathogenesis occurs in a large minority of infected people. Presently, there are neither viral nor cellular markers that predict the development of brain disease during HIV-1 infection. This study was conducted to determine whether there exist systematic diff...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701510104
更新日期:2007-10-01 00:00:00
abstract::Over the past decade there has been a revolution in the understanding and care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-associated disease. Much of this progress stems from a broader recognition of the importance of differences in viral types, including receptor preference(s), repl...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280590922838
更新日期:2005-04-01 00:00:00
abstract::Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0388-1
更新日期:2016-04-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00899-0
更新日期:2020-12-01 00:00:00
abstract::The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carria...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701802543
更新日期:2008-01-01 00:00:00
abstract::Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0151-4
更新日期:2013-04-01 00:00:00
abstract::Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure E...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00891-8
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abstract::HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114537
更新日期:1998-08-01 00:00:00
abstract::We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146898
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abstract::We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for oth...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0419-y
更新日期:2016-08-01 00:00:00
abstract::Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
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更新日期:2018-06-01 00:00:00
abstract::The objective of this study was to assess lithium safety and tolerability and to explore its impact on cognition, function, and neuroimaging biomarkers in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. Fifteen cognitively impaired HIV-infected subjects were enrolled in this 10-week ope...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280902758973
更新日期:2009-04-01 00:00:00
abstract::HIV-associated neurocognitive disorder (HAND) is characterized by chronic immune activation. We aimed to identify biomarkers associated with HAND and to investigate their association with cognitive function and sex, in a homogenous cohort of HIV-infected (HIV+) young adults, parenterally infected during early childhoo...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00785-4
更新日期:2020-02-01 00:00:00
abstract::A significant number of human immunodeficiency virus type 1 (HIV-1)-infected patients are alcoholics. Either alcohol or HIV alone induces morphological and functional damage to the nervous system. HIV-1 Tat is a potent transcriptional activator of the viral promoter, with the ability to modulate a number of cellular r...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280500516427
更新日期:2006-02-01 00:00:00
abstract::The last 3 years have seen a dramatic fall in mortality and morbidity from HIV infection. Four factors have contributed to this: an improved understanding of the pathogenesis of HIV infection; the availability of tests that could measure plasma viral burden; the development of new and more powerful drugs such as the p...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490521131
更新日期:2004-12-01 00:00:00
abstract::The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00914-4
更新日期:2021-01-06 00:00:00
abstract::In May 2012, the Division of AIDS Research at the National Institute of Mental Health (NIMH) organized the "Global NeuroAIDS Roundtable" in conjunction with the 11th International Symposium on Neurovirology and the 2012 Conference on HIV in the Nervous System. The meeting was held in New York, NY, USA and brought toge...
journal_title:Journal of neurovirology
pub_type:
doi:10.1007/s13365-012-0143-9
更新日期:2013-02-01 00:00:00