Abstract:
:With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of a systemic review. This review was carried out based on the existing PRISMA (Preferred Report for Systematic Review and Meta analyses) consensus statement. The data for this review was collected from four databases: Pubmed/Medline, NIH Litcovid, Embase, and Cochrane library and Preprint servers up till 30 June 2020. Search strategy comprised of a range of keywords from relevant medical subject headings which includes "SARS-COV-2," "COVID-19," and "meningoencephalitis." All peer reviewed, case-control, case report, pre print articles satisfying our inclusion criteria were involved in the study. Quantitative data was expressed in mean ± SD, while the qualitative date in percentages. Paired t test was used for analysing the data based on differences between mean and respective values with a p < 0.05 considered to be statistically significant. A total of 61 cases were included from 25 studies after screening from databases and preprint servers, out of which 54 of them had completed investigation profile and were included in the final analysis. Clinical, laboratory findings, neuroimaging abnormalities, and EEG findings were analyzed in detail. This present review summarizes the available evidences related to the occurrence of meningoencephalitis in COVID-19.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Mondal R,Ganguly U,Deb S,Shome G,Pramanik S,Bandyopadhyay D,Lahiri Ddoi
10.1007/s13365-020-00923-3subject
Has Abstractpub_date
2020-12-26 00:00:00eissn
1355-0284issn
1538-2443pii
10.1007/s13365-020-00923-3pub_type
杂志文章,评审abstract::In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280591002405
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abstract::The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00730-5
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abstract::Toscana virus (Bunyaviridae family, Phlebovirus genus) is a sandfly fever virus responsible for human neurological infections. Sandfly viruses are transmitted by insect vectors (Phlebotomus species) and the infection is present in climatic areas that allow the life cycle of the vector. The arthropode-borne Toscana vir...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280390247678
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abstract::In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909045382
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abstract::Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-017-0527-y
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abstract::The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490441130
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abstract::Maedi Visna Virus (MVV) is a prototypic lentivirus that causes infection only in cells of macrophage lineage, unlike the primate lentiviruses which infect both CD4+ T lymphocytes and macrophages. In primates, the earliest viral invasion is associated with the ability of the virus to infect and activate T cells which c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809113480
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abstract::Although highly active antiretroviral therapy (HAART) has reduced the incidence of dementia, a significant proportion of HIV-infected individuals cease therapy because of unacceptable side effects. Further, HAART is not available to the majority of HIV-infected people worldwide. Thus, animal models remain an important...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290101076
更新日期:2002-12-01 00:00:00
abstract::Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
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abstract::Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290049534
更新日期:2002-04-01 00:00:00
abstract::The most common complication of zoster in the elderly is postherpetic neuralgia, operationally defined as pain persisting longer than 1-2 months after rash. The cause of postherpetic neuralgia is unknown. Using polymerase chain reaction, we detected varicella zoster virus DNA in blood mononuclear cells from 11 of 51 p...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111018
更新日期:1995-03-01 00:00:00
abstract::Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280390218751
更新日期:2003-08-01 00:00:00
abstract::Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-016-0497-5
更新日期:2017-04-01 00:00:00
abstract::Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490521131
更新日期:2004-12-01 00:00:00
abstract::The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-017-0557-5
更新日期:2017-10-01 00:00:00
abstract::Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macrophages. Lack of remyelination has been attributed to insufficient pro...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0402-7
更新日期:2016-06-01 00:00:00
abstract::Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investiga...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809113497
更新日期:1998-10-01 00:00:00
abstract::Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associated with ADC but their specific contri...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280009013160
更新日期:2000-04-01 00:00:00
abstract::The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00914-4
更新日期:2021-01-06 00:00:00
abstract::Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0651-3
更新日期:2018-10-01 00:00:00
abstract::Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111008
更新日期:1995-03-01 00:00:00
abstract::Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/BF03210846
更新日期:2010-11-01 00:00:00
abstract::An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0632-6
更新日期:2018-08-01 00:00:00
abstract::A recombinant adenovirus vector bearing the IL-4 gene (AD-IL-4) was used to infect rat glioma C6 cells in culture at multiplicity of infections (MOI) from 50 to 1800. C6 cell proliferation was not altered significantly by adenoviral infection. However, IL-4 production increased in a dose-dependent manner. To ascertain...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114523
更新日期:1998-04-01 00:00:00
abstract::Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280802074539
更新日期:2008-08-01 00:00:00
abstract::Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure E...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00891-8
更新日期:2020-12-01 00:00:00
abstract::Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pr...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-010-0006-1
更新日期:2011-02-01 00:00:00
abstract::Neurodegeneration and human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are the major disease manifestations of HIV-1 colonization of the central nervous system (CNS). In the brain, HIV-1 replicates in microglial cells and infiltrating macrophages and it persists in a low-productive, noncytolytic s...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280390201263
更新日期:2003-06-01 00:00:00
abstract::We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0717-2
更新日期:2019-06-01 00:00:00
abstract::Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280009015823
更新日期:2000-06-01 00:00:00