JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy.

Abstract:

:Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 HIV+/PML survivors, all had detectable cytotoxic T lymphocytes (CTL) specific for JCV T or VP 1 proteins compared to none of the 3 HIV+/PML progressors tested. Of the 3 HIV-/PML patients, 1 was recently diagnosed with PML and showed evidence of neurologic improvement without any treatment. This patient had CTL specific for the VP1 protein of JCV. The other 2 HIV-/PML survivors were stable 3-8 years after the diagnosis of PML. They did not have any detectable CTL against JCV. These findings suggest that JCV-specific immune response is associated with favorable outcome in HIV+ individuals with PML. The lack of detectable JCV-specific CTL in 2 HIV-/PML survivors might indicate a burnt-out disease without sufficient antigenic stimulation to maintain the cellular immune response. The detection of JCV-specific CTL in an HIV- patient recently diagnosed with PML, who was showing evidence of neurological improvement without any treatment, indicates that this finding may be used as a favorable prognostic marker of disease evolution in the clinical management of patients with PML. As the quest for an effective treatment of PML continues, JCV-specific cellular immune response deserves further attention because it appears to play a crucial role in the prevention of disease progression.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Du Pasquier RA,Clark KW,Smith PS,Joseph JT,Mazullo JM,De Girolami U,Letvin NL,Koralnik IJ

doi

10.1080/13550280152537175

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

318-22

issue

4

eissn

1355-0284

issn

1538-2443

journal_volume

7

pub_type

杂志文章
  • Defining the roles for Vpr in HIV-1-associated neuropathogenesis.

    abstract::It is increasingly evident that the human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has a unique role in neuropathogenesis. Its ability to induce G2/M arrest coupled with its capacity to increase viral gene transcription gives it a unique role in sustaining viral replication and aiding in the establi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-016-0436-5

    authors: James T,Nonnemacher MR,Wigdahl B,Krebs FC

    更新日期:2016-08-01 00:00:00

  • Effort and neuropsychological performance in HIV-infected individuals on stable combination antiretroviral therapy.

    abstract::The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-017-0557-5

    authors: Paul R,Rhee G,Baker LM,Vaida F,Cooley SA,Ances BM

    更新日期:2017-10-01 00:00:00

  • Neurological evaluation of untreated human immunodeficiency virus infected adults in Ethiopia.

    abstract::Human immunodeficiency virus (HIV) has been implicated in neurological complications in developed countries. Developing countries have different viral clades and potentially different genetic and social risks for these complications. Baseline neurological performance measures associated with HIV infection have rarely ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280601169837

    authors: Clifford DB,Mitike MT,Mekonnen Y,Zhang J,Zenebe G,Melaku Z,Zewde A,Gessesse N,Wolday D,Messele T,Teshome M,Evans S

    更新日期:2007-01-01 00:00:00

  • Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization.

    abstract::Neurodegeneration and human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are the major disease manifestations of HIV-1 colonization of the central nervous system (CNS). In the brain, HIV-1 replicates in microglial cells and infiltrating macrophages and it persists in a low-productive, noncytolytic s...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280390201263

    authors: Su ZZ,Kang DC,Chen Y,Pekarskaya O,Chao W,Volsky DJ,Fisher PB

    更新日期:2003-06-01 00:00:00

  • Central nervous system correlates of behavioral deficits following simian immunodeficiency virus infection.

    abstract::Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280390218751

    authors: Weed MR,Hienz RD,Brady JV,Adams RJ,Mankowski JL,Clements JE,Zink MC

    更新日期:2003-08-01 00:00:00

  • Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions.

    abstract::In the era of the AIDS pandemic, progressive multifocal leukoencephalopathy (PML) has ceased being a rare disease. Prevalence estimates from clinical and pathological series suggest that up to 5% of all HIV-infected persons will develop PML. The extraordinary frequency with which PML attends HIV infection vastly excee...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1080/13550280390195261

    authors: Berger JR

    更新日期:2003-01-01 00:00:00

  • Neurological complications of human immunodeficiency virus infection in Zimbabwe-2005.

    abstract::Zimbabwe is a high prevalence area for HIV infection, and provides opportunities for studying complications of AIDS in both antiretroviral naive and treated groups of patients. Figures for HIV prevalence are among the highest in the world, but the number of people receiving treatment is very small. Economic and politi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1080/13550280500511766

    authors: Mielke J

    更新日期:2005-01-01 00:00:00

  • High-dose corticosteroids for acute cytomegalovirus-associated transverse myelitis in the immunocompetent patient: a case report and systematic review.

    abstract::We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-018-0717-2

    authors: Budhram A,Liu Y,Krawczyk M,Chan TLH,Burneo JG,Hosseini-Moghaddam SM,Shoesmith C

    更新日期:2019-06-01 00:00:00

  • Persistent pathogens in the parenchyma of the brain.

    abstract::It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma i...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:

    authors: Perry VH

    更新日期:2000-05-01 00:00:00

  • Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity.

    abstract::HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289809114537

    authors: Bratanich AC,Liu C,McArthur JC,Fudyk T,Glass JD,Mittoo S,Klassen GA,Power C

    更新日期:1998-08-01 00:00:00

  • A review of the potential mechanisms of neuronal toxicity associated with antiretroviral drugs.

    abstract::Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in people living with HIV. This effect was also observed in the central nervous system with the nowadays uncommon observation of dementias; yet in more recent works milder forms are still reported in 20-30% of optimally treated i...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-020-00874-9

    authors: De Benedetto I,Trunfio M,Guastamacchia G,Bonora S,Calcagno A

    更新日期:2020-10-01 00:00:00

  • Interruptions of antiretroviral therapy in human immunodeficiency virus infection: are they detrimental to neurocognitive functioning?

    abstract::Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study was carried out, comparing HIV-infected persons who had interrupted antiretroviral therapy in the pa...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550281003767710

    authors: Muñoz-Moreno JA,Fumaz CR,Prats A,Ferrer MJ,Negredo E,Pérez-Alvarez N,Moltó J,Gómez G,Garolera M,Clotet B

    更新日期:2010-05-01 00:00:00

  • Clinical features and preliminary studies of virological correlates of neurocognitive impairment among HIV-infected individuals in Nigeria.

    abstract::In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-012-0097-y

    authors: Royal W 3rd,Cherner M,Carr J,Habib AG,Akomolafe A,Abimiku A,Charurat M,Farley J,Oluyemisi A,Mamadu I,Johnson J,Ellis R,McCutchan JA,Grant I,Blattner WA

    更新日期:2012-06-01 00:00:00

  • Genotyping of human parechoviruses in Iranian young children with aseptic meningitis and sepsis-like illness.

    abstract::Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-013-0221-7

    authors: Rahimi P,Naser HM,Siadat SD,Sohrabi A,Mostafavi E,Motamedirad M,Bahramali G,Sadat SM,Ardestani MS

    更新日期:2013-12-01 00:00:00

  • Herpes simplex virus-1 and varicella-zoster virus latency in ganglia.

    abstract::Two human alpha-herpesviruses, herpes simplex virus (HSV)-1 and varicella zoster virus (VZV), account for the most frequent and serious neurologic disease caused by any of the eight human herpesviruses. Both HSV-1 and VZV become latent in ganglia. In this review, the authors describe features of latency for these viru...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1080/13550280390194000

    authors: Mitchell BM,Bloom DC,Cohrs RJ,Gilden DH,Kennedy PG

    更新日期:2003-04-01 00:00:00

  • Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study.

    abstract::Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0388-1

    authors: Tang Z,Dong E,Liu J,Liu Z,Wei W,Wang B,Li H,Tian J

    更新日期:2016-04-01 00:00:00

  • Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells.

    abstract::A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an R...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-020-00903-7

    authors: Azizi SA,Azizi SA

    更新日期:2020-10-01 00:00:00

  • The herpes simplex virus type 1 early gene (thymidine kinase) promoter is activated in neurons of brain, but not trigeminal ganglia, of transgenic mice in the absence of viral proteins.

    abstract::Latent infection of sensory neurons and reactivation are necessary for maintenance of herpes simplex virus type 1 (HSV-1) in its host population. It has been proposed that the HSV-1 early gene, thymidine kinase (TK), may play an important regulatory role in this process. The authors used reporter transgenic mice to te...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490279771

    authors: Loiacono CM,Myers R,Mitchell WJ

    更新日期:2004-04-01 00:00:00

  • HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter.

    abstract::Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s13365-014-0236-8

    authors: Keltner JR,Fennema-Notestine C,Vaida F,Wang D,Franklin DR,Dworkin RH,Sanders C,McCutchan JA,Archibald SL,Miller DJ,Kesidis G,Cushman C,Kim SM,Abramson I,Taylor MJ,Theilmann RJ,Julaton MD,Notestine RJ,Corkran S,Chern

    更新日期:2014-06-01 00:00:00

  • The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT).

    abstract::The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0361-z

    authors: Carpenter D,Hsiang C,Jiang X,Osorio N,BenMohamed L,Jones C,Wechsler SL

    更新日期:2015-10-01 00:00:00

  • Molecular analysis of JC virus genotypes circulating among the Italian healthy population.

    abstract::JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280390241269

    authors: Pagani E,Delbue S,Mancuso R,Borghi E,Tarantini L,Ferrante P

    更新日期:2003-10-01 00:00:00

  • Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals.

    abstract::We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for oth...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0419-y

    authors: Crossley KM,Agnihotri S,Chaganti J,Rodriguez ML,McNally LP,Venna N,Turbett SE,Gutman M,Morey A,Koralnik IJ,Brew BJ

    更新日期:2016-08-01 00:00:00

  • Glycogen synthase kinase-3beta (GSK-3beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons.

    abstract::Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280903168131

    authors: Nguyen TB,Lucero GR,Chana G,Hult BJ,Tatro ET,Masliah E,Grant I,Achim CL,Everall IP,HIV Neurobehavioral Research Group.

    更新日期:2009-09-01 00:00:00

  • Meningoencephalitis associated with COVID-19: a systematic review.

    abstract::With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-020-00923-3

    authors: Mondal R,Ganguly U,Deb S,Shome G,Pramanik S,Bandyopadhyay D,Lahiri D

    更新日期:2020-12-26 00:00:00

  • PCR detection of host and HIV-1 sequences from archival brain tissue.

    abstract::Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associated with ADC but their specific contri...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550280009013160

    authors: Smith KM,Crandall KA,Kneissl ML,Navia BA

    更新日期:2000-04-01 00:00:00

  • Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes.

    abstract::Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289609146542

    authors: Sumner C,Shinohara T,Durham L,Traub R,Major EO,Amemiya K

    更新日期:1996-04-01 00:00:00

  • Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

    abstract::Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macrophages. Lack of remyelination has been attributed to insufficient pro...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0402-7

    authors: Benner B,Martorell AJ,Mahadevan P,Najm FJ,Tesar PJ,Freundt EC

    更新日期:2016-06-01 00:00:00

  • HSV-1 encephalitis relapse after epilepsy surgery: a case report and review of the literature.

    abstract::Herpes simplex encephalitis relapses have been rarely reported, with only few cases occurring after neurosurgical interventions. A young man presented a late herpes simplex encephalitis relapse after left antero-mesial temporal resection for his refractory temporal lobe epilepsy. Eight days after surgery, he developed...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00796-1

    authors: Mantero V,Cossu M,Rigamonti A,Fiumani A,Basilico P,Tassi L,Salmaggi A

    更新日期:2020-02-01 00:00:00

  • Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.

    abstract::The objective of this study was to assess lithium safety and tolerability and to explore its impact on cognition, function, and neuroimaging biomarkers in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. Fifteen cognitively impaired HIV-infected subjects were enrolled in this 10-week ope...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280902758973

    authors: Schifitto G,Zhong J,Gill D,Peterson DR,Gaugh MD,Zhu T,Tivarus M,Cruttenden K,Maggirwar SB,Gendelman HE,Dewhurst S,Gelbard HA

    更新日期:2009-04-01 00:00:00

  • Expression of pseudorabies virus-encoded long noncoding RNAs in epithelial cells and neurons.

    abstract::Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-018-0651-3

    authors: Guan X,Liu J,Jiang H,Wu CX,Chen HC,Liu ZF

    更新日期:2018-10-01 00:00:00