Abstract:
:The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Richt JA,Alexander RC,Herzog S,Hooper DC,Kean R,Spitsin S,Bechter K,Schüttler R,Feldmann H,Heiske A,Fu ZF,Dietzschold B,Rott R,Koprowski Hdoi
10.3109/13550289709015807subject
Has Abstractpub_date
1997-04-01 00:00:00pages
174-8issue
2eissn
1355-0284issn
1538-2443journal_volume
3pub_type
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