Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders.

Abstract:

:The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Richt JA,Alexander RC,Herzog S,Hooper DC,Kean R,Spitsin S,Bechter K,Schüttler R,Feldmann H,Heiske A,Fu ZF,Dietzschold B,Rott R,Koprowski H

doi

10.3109/13550289709015807

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

174-8

issue

2

eissn

1355-0284

issn

1538-2443

journal_volume

3

pub_type

杂志文章
  • Safety and efficacy of interferon-alpha in 167 patients with human T-cell lymphotropic virus type 1-associated myelopathy.

    abstract::A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280701397627

    authors: Arimura K,Nakagawa M,Izumo S,Usuku K,Itoyama Y,Kira J,Osame M

    更新日期:2007-08-01 00:00:00

  • Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.

    abstract::Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289509111008

    authors: Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

    更新日期:1995-03-01 00:00:00

  • Inhibition of nitric oxide synthase-2 reduces the severity of mouse hepatitis virus-induced demyelination: implications for NOS2/NO regulation of chemokine expression and inflammation.

    abstract::Infection of C57BL/6 mice with mouse hepatitis virus strain V5A13.1 (MHV-V5A13.1) results in an acute encephalitis followed by a chronic, progressive demyelinating disease with clinical and histological similarities to the human demyelinating disease Multiple Sclerosis (MS). Studies were undertaken to evaluate the con...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909029745

    authors: Lane TE,Fox HS,Buchmeier MJ

    更新日期:1999-02-01 00:00:00

  • A review of the potential mechanisms of neuronal toxicity associated with antiretroviral drugs.

    abstract::Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in people living with HIV. This effect was also observed in the central nervous system with the nowadays uncommon observation of dementias; yet in more recent works milder forms are still reported in 20-30% of optimally treated i...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-020-00874-9

    authors: De Benedetto I,Trunfio M,Guastamacchia G,Bonora S,Calcagno A

    更新日期:2020-10-01 00:00:00

  • Intracerebral infection with murine cytomegalovirus induces CXCL10 and is restricted by adoptive transfer of splenocytes.

    abstract::The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490441130

    authors: Cheeran MC,Gekker G,Hu S,Min X,Cox D,Lokensgard JR

    更新日期:2004-06-01 00:00:00

  • Localization of sequences within the latency-related gene of bovine herpesvirus 1 that inhibit mammalian cell growth.

    abstract::The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280500385286

    authors: Geiser V,Jones C

    更新日期:2005-12-01 00:00:00

  • Expression of pseudorabies virus-encoded long noncoding RNAs in epithelial cells and neurons.

    abstract::Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-018-0651-3

    authors: Guan X,Liu J,Jiang H,Wu CX,Chen HC,Liu ZF

    更新日期:2018-10-01 00:00:00

  • HIV eradication symposium: will the brain be left behind?

    abstract::On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...

    journal_title:Journal of neurovirology

    pub_type:

    doi:10.1007/s13365-015-0322-6

    authors: Brew BJ,Robertson K,Wright EJ,Churchill M,Crowe SM,Cysique LA,Deeks S,Garcia JV,Gelman B,Gray LR,Johnson T,Joseph J,Margolis DM,Mankowski JL,Spencer B

    更新日期:2015-06-01 00:00:00

  • Detection of infectious agents in brain of patients with acute hemorrhagic leukoencephalitis.

    abstract::Acute hemorrhagic leukoencephalitis (AHL) is a rare and usually fatal disorder characterized clinically by an acute onset of neurologic abnormalities. It may occur in association with a viral illness or vaccination. Radiology and brain biopsy are essential for the diagnosis. The etiology of AHL is unclear. We postulat...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280260422749

    authors: An SF,Groves M,Martinian L,Kuo LT,Scaravilli F

    更新日期:2002-10-01 00:00:00

  • Future trends in neurovirology: neuronal survival during virus infection and analysis of virus-specific T cells in central nervous system tissues.

    abstract::The recent ability to quantitate and localize the interaction of antigen-specific T cells in the central nervous system during infectious and autoimmune diseases will greatly enhance our understanding of the molecular and biologic basis of virus-induced diseases of the nervous and other systems. ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1080/13550280490468438

    authors: Oldstone MB

    更新日期:2004-08-01 00:00:00

  • Ganciclovir-resistant cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient.

    abstract::We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and b...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550281003682539

    authors: Arslan F,Tabak F,Avşar E,Midilli K,Mert A,Ozaras R,Soysal T,Ozturk R,Ferhanoglu B

    更新日期:2010-03-01 00:00:00

  • The stability of herpes simplex virus type I genomes in infected Vero cells undergoing viral induced apoptosis.

    abstract::Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280600975358

    authors: Su YH,Zhang X,Aiamkitsumrit B,Tang Q,Maul G,Fraser NW,Block TM

    更新日期:2006-10-01 00:00:00

  • Progressive multifocal leukoencephalopathy in Zambia is caused by JC virus with prototype regulatory region.

    abstract::There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00746-x

    authors: Mubanga E,Patel A,Siddiqi OK,Hanson BA,Dang X,Lakhi S,Mulundu G,Bender N,Koralnik IJ

    更新日期:2019-08-01 00:00:00

  • Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.

    abstract::The objective of this study was to assess lithium safety and tolerability and to explore its impact on cognition, function, and neuroimaging biomarkers in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. Fifteen cognitively impaired HIV-infected subjects were enrolled in this 10-week ope...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280902758973

    authors: Schifitto G,Zhong J,Gill D,Peterson DR,Gaugh MD,Zhu T,Tivarus M,Cruttenden K,Maggirwar SB,Gendelman HE,Dewhurst S,Gelbard HA

    更新日期:2009-04-01 00:00:00

  • MRI of spinal cord in MS.

    abstract::Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:

    authors: Bastianello S,Paolillo A,Giugni E,Giuliani S,Evangelisti G,Luccichenti G,Angeloni U,Colonnese C,Salvetti M,Gasperini C,Pozzilli C,Fieschi C

    更新日期:2000-05-01 00:00:00

  • Molecular analysis of JC virus genotypes circulating among the Italian healthy population.

    abstract::JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280390241269

    authors: Pagani E,Delbue S,Mancuso R,Borghi E,Tarantini L,Ferrante P

    更新日期:2003-10-01 00:00:00

  • Clinical implications of nucleic acid amplification methods for the diagnosis of viral infections of the nervous system.

    abstract::Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.3109/13550289609146880

    authors: Weber T,Frye S,Bodemer M,Otto M,Lüke W

    更新日期:1996-06-01 00:00:00

  • Clinical features and preliminary studies of virological correlates of neurocognitive impairment among HIV-infected individuals in Nigeria.

    abstract::In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-012-0097-y

    authors: Royal W 3rd,Cherner M,Carr J,Habib AG,Akomolafe A,Abimiku A,Charurat M,Farley J,Oluyemisi A,Mamadu I,Johnson J,Ellis R,McCutchan JA,Grant I,Blattner WA

    更新日期:2012-06-01 00:00:00

  • Genetic risk factors in multiple sclerosis and approaches to their identification.

    abstract::Development of multiple sclerosis (MS) is believed to involve genetic as well as environmental factors. A complicating aspect to the study of aetiological factors in MS concerns the possible existence of genetically different subtypes of the disease. In addition, a relatively large number of susceptibility genes could...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:

    authors: Rasmussen HB,Clausen J

    更新日期:2000-05-01 00:00:00

  • Disseminated cortical and subcortical lesions in neonatal enterovirus 71 encephalitis.

    abstract::Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-020-00843-2

    authors: Nakamura R,Chong PF,Haraguchi K,Katano H,Tanaka-Taya K,Kira R

    更新日期:2020-10-01 00:00:00

  • Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model.

    abstract::Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280390173319

    authors: Leyssen P,Paeshuyse J,Charlier N,Van Lommel A,Drosten C,De Clercq E,Neyts J

    更新日期:2003-02-01 00:00:00

  • Central nervous system (CNS) enterovirus infections: A single center retrospective study on clinical features, diagnostic studies, and outcome.

    abstract::Enteroviruses (EV) are responsible for a large number of meningoencephalitis cases, especially in children. The objective of this study was to identify modes of diagnosis including the significance of respiratory and cerebrospinal fluid samples, associated clinical characteristics, inpatient management, and outcome of...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00784-5

    authors: Torres SD,Jia DT,Schorr EM,Park BL,Boubour A,Boehme A,Ankam JV,Gofshteyn JS,Tyshkov C,Green DA,Vargas W,Zucker J,Yeshokumar AK,Thakur KT

    更新日期:2020-02-01 00:00:00

  • Diffuse large B cell lymphoma secondary to JC virus in progressive multifocal leukoencephalopathy.

    abstract::We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00760-z

    authors: Reddi A,Patel N,Morris NA

    更新日期:2019-12-01 00:00:00

  • Human cytomegalovirus induces IL-6 and TNF alpha from macrophages and microglial cells: possible role in neurotoxicity.

    abstract::Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregates preferentially infected a microglia...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289509113968

    authors: Pulliam L,Moore D,West DC

    更新日期:1995-06-01 00:00:00

  • Pain, psychoaffective symptoms, and quality of life in human T cell lymphotropic virus type 1 (HTLV-1): a cross-sectional study.

    abstract::The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-020-00914-4

    authors: Dos Santos DN,Sá KN,Queirós FC,Paixão AB,Santos KOB,de Andrade RCP,Camatti JR,Baptista AF

    更新日期:2021-01-06 00:00:00

  • Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.

    abstract::Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the s...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0239-5

    authors: Coughlin JM,Wang Y,Ma S,Yue C,Kim PK,Adams AV,Roosa HV,Gage KL,Stathis M,Rais R,Rojas C,McGlothan JL,Watkins CC,Sacktor N,Guilarte TR,Zhou Y,Sawa A,Slusher BS,Caffo B,Kassiou M,Endres CJ,Pomper MG

    更新日期:2014-06-01 00:00:00

  • The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection.

    abstract::When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490261716

    authors: Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

    更新日期:2004-02-01 00:00:00

  • Machine learning models reveal neurocognitive impairment type and prevalence are associated with distinct variables in HIV/AIDS.

    abstract::Neurocognitive impairment (NCI) among HIV-infected patients is heterogeneous in its reported presentations and frequencies. To determine the prevalence of NCI and its associated subtypes as well as predictive variables, we investigated patients with HIV/AIDS receiving universal health care. Recruited adult HIV-infecte...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00791-6

    authors: Tu W,Chen PA,Koenig N,Gomez D,Fujiwara E,Gill MJ,Kong L,Power C

    更新日期:2020-02-01 00:00:00

  • The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease.

    abstract::This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot b...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1080/13550280802448451

    authors: Dolei A,Perron H

    更新日期:2009-01-01 00:00:00

  • Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls.

    abstract::The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible fo...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00817-z

    authors: Vegezzi E,Berzero G,Barbetta D,Colombo AA,Borsani O,Bernasconi P,Compagno F,Zecca M,Campanini G,Simoncelli A,Paoletti M,Pichiecchio A,Baldanti F,Brunetti E,Marchioni E

    更新日期:2020-04-01 00:00:00