Disseminated cortical and subcortical lesions in neonatal enterovirus 71 encephalitis.

Abstract:

:Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions around the periventricular regions. In this study, we report a case of a patient with neonatal encephalitis who presented with normal white blood cell counts in the initial cerebrospinal fluid analysis. A lumbar puncture retap identified pleocytosis, and polymerase chain reaction assays detected enterovirus 71 in the blood and stool samples. Furthermore, MRI revealed atypical disseminated cortical and subcortical white matter lesions on diffusion weighted images, and neuroradiological re-evaluation showed necrotic changes 2 weeks later. This unique case expands our knowledge of the spectrum of neurological disorders due to enterovirus 71 infection in neonatal period.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Nakamura R,Chong PF,Haraguchi K,Katano H,Tanaka-Taya K,Kira R

doi

10.1007/s13365-020-00843-2

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

790-792

issue

5

eissn

1355-0284

issn

1538-2443

pii

10.1007/s13365-020-00843-2

journal_volume

26

pub_type

杂志文章
  • Analysis of herpes simplex virus type 1 glycoprotein D nucleotide sequence in human herpes simplex encephalitis.

    abstract::Viral factors responsible for HSV neurovirulence in humans are still unknown. The aim of this work was to investigate the hypothesis that viral variants might contribute to the specific neurovirulence of some HSV strains. HSV-1 DNA was recovered from cerebrospinal fluid (CSF) in ten patients with HSV encephalitis (HSE...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289609146892

    authors: Rozenberg F,Lebon P

    更新日期:1996-08-01 00:00:00

  • Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.

    abstract::Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289509111008

    authors: Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

    更新日期:1995-03-01 00:00:00

  • Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis.

    abstract::Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is an inflammatory disease of the spinal cord and clinically characterized by progressive spastic paraparesis, urinary incontinence, and mild sen...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-020-00881-w

    authors: Nozuma S,Kubota R,Jacobson S

    更新日期:2020-10-01 00:00:00

  • Restricted replication of herpes simplex virus in satellite glial cell cultures clonally derived from adult mice.

    abstract::To determine the possible influence of satellite glial cells on restricting the spread of herpes simplex virus in the peripheral nervous system, HSV replication was studied in clonally derived cultures of satellite glial cells from adult animals. Satellite cells were purified by exploiting their close anatomical assoc...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909029479

    authors: Wilkinson R,Leaver C,Simmons A,Pereira RA

    更新日期:1999-08-01 00:00:00

  • Age exacerbates HIV-associated white matter abnormalities.

    abstract::Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0386-3

    authors: Seider TR,Gongvatana A,Woods AJ,Chen H,Porges EC,Cummings T,Correia S,Tashima K,Cohen RA

    更新日期:2016-04-01 00:00:00

  • HIV eradication symposium: will the brain be left behind?

    abstract::On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...

    journal_title:Journal of neurovirology

    pub_type:

    doi:10.1007/s13365-015-0322-6

    authors: Brew BJ,Robertson K,Wright EJ,Churchill M,Crowe SM,Cysique LA,Deeks S,Garcia JV,Gelman B,Gray LR,Johnson T,Joseph J,Margolis DM,Mankowski JL,Spencer B

    更新日期:2015-06-01 00:00:00

  • Progressive multifocal leukoencephalopathy treated with nivolumab.

    abstract::Therapy for progressive multifocal leukoencephalopathy (PML) remains challenging since there are no antiviral therapies available for JC virus. Immune reconstitution has improved the prognosis in many settings where PML occurs, but it often is not possible in PML patients with hematologic malignancies. We describe the...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00738-x

    authors: Hoang E,Bartlett NL,Goyal MS,Schmidt RE,Clifford DB

    更新日期:2019-04-01 00:00:00

  • Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity.

    abstract::HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289809114537

    authors: Bratanich AC,Liu C,McArthur JC,Fudyk T,Glass JD,Mittoo S,Klassen GA,Power C

    更新日期:1998-08-01 00:00:00

  • A mechanism for selective induction of 2'-5' oligoadenylate synthetase, anti-viral state, but not MHC class I genes by interferon-beta in neurons.

    abstract::Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral inf...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909021998

    authors: Massa PT,Whitney LW,Wu C,Ropka SL,Jarosinski KW

    更新日期:1999-04-01 00:00:00

  • Susceptibility to a neurotropic virus and its changing distribution in the developing brain is a function of CNS maturity.

    abstract::Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289709015791

    authors: Oliver KR,Scallan MF,Dyson H,Fazakerley JK

    更新日期:1997-02-01 00:00:00

  • Herpes simplex virus latency after direct ganglion virus inoculation.

    abstract::Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investiga...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289809113497

    authors: Hay KA,Edris WA,Gaydos A,Tenser RB

    更新日期:1998-10-01 00:00:00

  • The role of depression chronicity and recurrence on neurocognitive dysfunctions in HIV-infected adults.

    abstract::Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0368-5

    authors: Cysique LA,Dermody N,Carr A,Brew BJ,Teesson M

    更新日期:2016-02-01 00:00:00

  • Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease.

    abstract::Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0293-z

    authors: Paul RH,Joska JA,Woods C,Seedat S,Engelbrecht S,Hoare J,Heaps J,Valcour V,Ances B,Baker LM,Salminen LE,Stein DJ

    更新日期:2014-12-01 00:00:00

  • HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors.

    abstract::Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pr...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s13365-010-0006-1

    authors: Heaton RK,Franklin DR,Ellis RJ,McCutchan JA,Letendre SL,Leblanc S,Corkran SH,Duarte NA,Clifford DB,Woods SP,Collier AC,Marra CM,Morgello S,Mindt MR,Taylor MJ,Marcotte TD,Atkinson JH,Wolfson T,Gelman BB,McArthur JC,

    更新日期:2011-02-01 00:00:00

  • Decreased MEG beta oscillations in HIV-infected older adults during the resting state.

    abstract::The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-013-0220-8

    authors: Becker KM,Heinrichs-Graham E,Fox HS,Robertson KR,Sandkovsky U,O'Neill J,Swindells S,Wilson TW

    更新日期:2013-12-01 00:00:00

  • Neurological complications of human immunodeficiency virus infection in Zimbabwe-2005.

    abstract::Zimbabwe is a high prevalence area for HIV infection, and provides opportunities for studying complications of AIDS in both antiretroviral naive and treated groups of patients. Figures for HIV prevalence are among the highest in the world, but the number of people receiving treatment is very small. Economic and politi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1080/13550280500511766

    authors: Mielke J

    更新日期:2005-01-01 00:00:00

  • NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain.

    abstract::Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280802105002

    authors: Deb C,Howe CL

    更新日期:2008-05-01 00:00:00

  • Efficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant.

    abstract::A neuroinvasive/neuropathogenic SIV variant termed SIVmac182 was previously isolated and characterized (Watry et al, 1994). This neuroinvasive strain was derived from the uncloned strain SIVmac251 through serial animal passage of infected microglia, unlike previously reported neurovirulent strains. Importantly, the vi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289809114528

    authors: Strelow LI,Watry DD,Fox HS,Nelson JA

    更新日期:1998-06-01 00:00:00

  • Clinical implications of nucleic acid amplification methods for the diagnosis of viral infections of the nervous system.

    abstract::Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.3109/13550289609146880

    authors: Weber T,Frye S,Bodemer M,Otto M,Lüke W

    更新日期:1996-06-01 00:00:00

  • Expression of TSLC1 in patients with HAM/TSP.

    abstract::Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-020-00838-z

    authors: Takenouchi N,Tanaka M,Sato T,Yao J,Fujisawa JI,Izumo S,Kubota R,Matsuura E

    更新日期:2020-06-01 00:00:00

  • Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study.

    abstract::Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0388-1

    authors: Tang Z,Dong E,Liu J,Liu Z,Wei W,Wang B,Li H,Tian J

    更新日期:2016-04-01 00:00:00

  • Age-dependent poliomyelitis in mice is associated with respiratory failure and viral replication in the central nervous system and lung.

    abstract::Age-dependent poliomyelitis (ADPM) is a virally induced neuroparalytic disease of mice and a model for amyotrophic lateral sclerosis (ALS). ADPM is triggered in genetically susceptible mice by immunosuppression and infection with lactate dehydrogenase-elevating virus (LDV). Both ADPM and ALS are characterized by progr...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280152403308

    authors: Schlenker EH,Jones QA,Rowland RR,Steffen-Bien M,Cafruny WA

    更新日期:2001-06-01 00:00:00

  • Diffuse large B cell lymphoma secondary to JC virus in progressive multifocal leukoencephalopathy.

    abstract::We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospi...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00760-z

    authors: Reddi A,Patel N,Morris NA

    更新日期:2019-12-01 00:00:00

  • Crack cocaine use impairs anterior cingulate and prefrontal cortex function in women with HIV infection.

    abstract::Crack cocaine use is associated with impaired verbal memory in HIV-infected women more than uninfected women. To understand the neural basis for this impairment, this study examined the effects of crack cocaine use on activation of the prefrontal cortex (PFC) and strategic encoding during a verbal memory task in HIV-i...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0250-x

    authors: Meyer VJ,Little DM,Fitzgerald DA,Sundermann EE,Rubin LH,Martin EM,Weber KM,Cohen MH,Maki PM

    更新日期:2014-08-01 00:00:00

  • Alterations in blood-brain barrier glucose transport in SIV-infected macaques.

    abstract::The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909021298

    authors: Mankowski JL,Queen SE,Kirstein LM,Spelman JP,Laterra J,Simpson IA,Adams RJ,Clements JE,Zink MC

    更新日期:1999-12-01 00:00:00

  • Cognitive behavioural impairment with irreversible sensorineural deafness as a complication of West Nile encephalitis.

    abstract::Despite common clinical features to suggest encephalitis, different viral encephalitides are known to have some specific clinical features, which if present, may suggest infection by a particular virus. West Nile viral (WNV) encephalitis has not been described with any specific diagnostic feature so far. In this conte...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00733-2

    authors: Pradhan S,Anand S,Choudhury SS

    更新日期:2019-06-01 00:00:00

  • Effects on brain tumor cell proliferation by an adenovirus vector that bears the interleukin-4 gene.

    abstract::A recombinant adenovirus vector bearing the IL-4 gene (AD-IL-4) was used to infect rat glioma C6 cells in culture at multiplicity of infections (MOI) from 50 to 1800. C6 cell proliferation was not altered significantly by adenoviral infection. However, IL-4 production increased in a dose-dependent manner. To ascertain...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289809114523

    authors: Wei MX,Li F,Ono Y,Gauldie J,Chiocca EA

    更新日期:1998-04-01 00:00:00

  • Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus.

    abstract::Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490521131

    authors: Marcario JK,Manaye KF,SantaCruz KS,Mouton PR,Berman NE,Cheney PD

    更新日期:2004-12-01 00:00:00

  • The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection.

    abstract::When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490261716

    authors: Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

    更新日期:2004-02-01 00:00:00

  • Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus.

    abstract::The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1007/s13365-014-0285-z

    authors: Daep CA,Muñoz-Jordán JL,Eugenin EA

    更新日期:2014-12-01 00:00:00