Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals.


:We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.


J Neurovirol


Journal of neurovirology


Crossley KM,Agnihotri S,Chaganti J,Rodriguez ML,McNally LP,Venna N,Turbett SE,Gutman M,Morey A,Koralnik IJ,Brew BJ




Has Abstract


2016-08-01 00:00:00














  • Neural dysregulation during a working memory task in human immunodeficiency virus-seropositive and hepatitis C coinfected individuals.

    abstract::Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

    journal_title:Journal of neurovirology

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    authors: Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

    更新日期:2014-08-01 00:00:00

  • Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

    abstract::Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macrophages. Lack of remyelination has been attributed to insufficient pro...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Benner B,Martorell AJ,Mahadevan P,Najm FJ,Tesar PJ,Freundt EC

    更新日期:2016-06-01 00:00:00

  • Human encephalitis caused by pseudorabies virus infection: a case report.

    abstract::Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of hu...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Wang D,Tao X,Fei M,Chen J,Guo W,Li P,Wang J

    更新日期:2020-06-01 00:00:00

  • Subtype associations with HIV-associated neurocognitive disorder in China.

    abstract::Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

    更新日期:2016-04-01 00:00:00

  • A mechanism for selective induction of 2'-5' oligoadenylate synthetase, anti-viral state, but not MHC class I genes by interferon-beta in neurons.

    abstract::Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral inf...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Massa PT,Whitney LW,Wu C,Ropka SL,Jarosinski KW

    更新日期:1999-04-01 00:00:00

  • GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity.

    abstract::Excessive glutamate neurotransmission has been implicated in neuronal injury in many disorders of the central nervous system (CNS), including human immunodeficiency virus (HIV)-associated dementia. Gp120IIIB is a strain of a HIV glycoprotein with specificity for the CXCR4 receptor that induces neuronal apoptosis in in...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Thomas AG,Bodner A,Ghadge G,Roos RP,Slusher BS

    更新日期:2009-09-01 00:00:00

  • Relationship between brain large artery characteristics and their downstream arterioles.

    abstract::We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Gutierrez J,Murray J,Chon C,Morgello S

    更新日期:2018-02-01 00:00:00

  • Prophylactic and therapeutic effects of human immunoglobulin on the pathobiology of HSV-1 infection, latency, and reactivation in mice.

    abstract::Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Dalai SK,Pesnicak L,Miller GF,Straus SE

    更新日期:2002-02-01 00:00:00

  • PCR detection of host and HIV-1 sequences from archival brain tissue.

    abstract::Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associated with ADC but their specific contri...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Smith KM,Crandall KA,Kneissl ML,Navia BA

    更新日期:2000-04-01 00:00:00

  • Pain, psychoaffective symptoms, and quality of life in human T cell lymphotropic virus type 1 (HTLV-1): a cross-sectional study.

    abstract::The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Dos Santos DN,Sá KN,Queirós FC,Paixão AB,Santos KOB,de Andrade RCP,Camatti JR,Baptista AF

    更新日期:2021-01-06 00:00:00

  • Genetic risk factors in multiple sclerosis and approaches to their identification.

    abstract::Development of multiple sclerosis (MS) is believed to involve genetic as well as environmental factors. A complicating aspect to the study of aetiological factors in MS concerns the possible existence of genetically different subtypes of the disease. In addition, a relatively large number of susceptibility genes could...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Rasmussen HB,Clausen J

    更新日期:2000-05-01 00:00:00

  • CXC chemokine receptors in the central nervous system: Role in cerebellar neuromodulation and development.

    abstract::Chemokines and their receptors are constitutively present in the central nervous system (CNS), expressed in neurons and glial cells. Much evidence suggests that, beyond their involvement in neuroinflammation, these proteins play a role in neurodevelopment and neurophysiological signaling. The goal of this review is to...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Ragozzino D

    更新日期:2002-12-01 00:00:00

  • Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity.

    abstract::HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Bratanich AC,Liu C,McArthur JC,Fudyk T,Glass JD,Mittoo S,Klassen GA,Power C

    更新日期:1998-08-01 00:00:00

  • Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis.

    abstract::A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly eleva...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Singhal T,Solomon I,Akbik F,Smirnakis S,Vaitkevicius H

    更新日期:2020-02-01 00:00:00

  • Nonhuman primate models of NeuroAIDS.

    abstract::Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审


    authors: Williams R,Bokhari S,Silverstein P,Pinson D,Kumar A,Buch S

    更新日期:2008-08-01 00:00:00

  • Central nervous system correlates of behavioral deficits following simian immunodeficiency virus infection.

    abstract::Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Weed MR,Hienz RD,Brady JV,Adams RJ,Mankowski JL,Clements JE,Zink MC

    更新日期:2003-08-01 00:00:00

  • JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy.

    abstract::Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Du Pasquier RA,Clark KW,Smith PS,Joseph JT,Mazullo JM,De Girolami U,Letvin NL,Koralnik IJ

    更新日期:2001-08-01 00:00:00

  • Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays.

    abstract::To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Takemoto M,Kira R,Kusuhara K,Torisu H,Sakai Y,Hara T

    更新日期:2005-07-01 00:00:00

  • Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders.

    abstract::The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Richt JA,Alexander RC,Herzog S,Hooper DC,Kean R,Spitsin S,Bechter K,Schüttler R,Feldmann H,Heiske A,Fu ZF,Dietzschold B,Rott R,Koprowski H

    更新日期:1997-04-01 00:00:00

  • Neurological evaluation of untreated human immunodeficiency virus infected adults in Ethiopia.

    abstract::Human immunodeficiency virus (HIV) has been implicated in neurological complications in developed countries. Developing countries have different viral clades and potentially different genetic and social risks for these complications. Baseline neurological performance measures associated with HIV infection have rarely ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Clifford DB,Mitike MT,Mekonnen Y,Zhang J,Zenebe G,Melaku Z,Zewde A,Gessesse N,Wolday D,Messele T,Teshome M,Evans S

    更新日期:2007-01-01 00:00:00

  • Human immunodeficiency virus-associated cytomegalovirus infection with multiple small vessel cerebral infarcts in the setting of early immune reconstitution.

    abstract::Cytomegalovirus (CMV) infection is an important cause of neurologic disease in the context of advanced human immunodeficiency virus (HIV) infection and is recognized as a cause of immune reconstitution inflammatory syndrome (IRIS) after initiation of highly active antiretroviral therapy (HAART). Central nervous system...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Anderson AM,Fountain JA,Green SB,Bloom SA,Palmore MP

    更新日期:2010-03-01 00:00:00

  • The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection.

    abstract::When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

    更新日期:2004-02-01 00:00:00

  • Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.

    abstract::Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

    更新日期:1995-03-01 00:00:00

  • The University of California San Diego performance-based skills assessment: a useful tool to detect mild everyday functioning difficulties in HIV-infected patients with very good immunological condition.

    abstract::Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure E...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Delle Donne V,Ciccarelli N,Massaroni V,Borghetti A,Dusina A,Farinacci D,Visconti E,Tamburrini E,Fabbiani M,Di Giambenedetto S

    更新日期:2020-12-01 00:00:00

  • Safety and efficacy of interferon-alpha in 167 patients with human T-cell lymphotropic virus type 1-associated myelopathy.

    abstract::A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Arimura K,Nakagawa M,Izumo S,Usuku K,Itoyama Y,Kira J,Osame M

    更新日期:2007-08-01 00:00:00

  • Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors.

    abstract::A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...

    journal_title:Journal of neurovirology

    pub_type: 临床试验,杂志文章


    authors: Sacktor NC,Skolasky RL,Lyles RH,Esposito D,Selnes OA,McArthur JC

    更新日期:2000-02-01 00:00:00

  • Diplopia as isolated presentation of varicella zoster central nervous system reactivation.

    abstract::Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivati...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Del Borgo C,Belvisi V,Valli MB,Currà A,Pozzetto I,Sepe M,Mastroianni CM

    更新日期:2017-08-01 00:00:00

  • Giant cell encephalitis and microglial infection with mucosally transmitted simian-human immunodeficiency virus SHIVSF162P3N in rhesus macaques.

    abstract::Neurocognitive disorders such as dementia and cognitive/motor impairments are among the most significant complications associated with human immunodeficiency virus (HIV) infection, especially in aging populations, yet the pathogenesis remains poorly understood. Activated macrophages and microglia in white matter along...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Harbison C,Zhuang K,Gettie A,Blanchard J,Knight H,Didier P,Cheng-Mayer C,Westmoreland S

    更新日期:2014-02-01 00:00:00

  • Cytotoxicity of glioblastoma cells mediated ex vivo by varicella-zoster virus-specific T cells.

    abstract::Clinical or laboratory evidence of varicella-zoster virus (VZV) infection has been consistently associated with lower glioma risk in case-control studies, suggesting a protective effect of VZV against glioma. We formulated the following explanatory hypotheses: reactivated VZV preferentially infects and kills gliomas c...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Canniff J,Donson AM,Foreman NK,Weinberg A

    更新日期:2011-10-01 00:00:00

  • The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT).

    abstract::The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章


    authors: Carpenter D,Hsiang C,Jiang X,Osorio N,BenMohamed L,Jones C,Wechsler SL

    更新日期:2015-10-01 00:00:00