Abstract:
:Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral infections of the CNS. To the contrary, in the present study, induction of functional antiviral state by IFN-beta in neurons compared to astrocytes was found to be highly efficient with respect to both viral replication and protection from cytopathic effects. A candidate antiviral state gene found to be efficiently induced in neurons by IFN-beta was the 2'-5'-oligoadenylate synthetase (OAS) gene. Unlike MHC class I genes, induction of OAS was comparable in neurons and astrocytes indicating differential expression in these neural cell types. Analysis of OAS gene promoter activity indicated that induction of the OAS gene by IFN-beta was dependent on a region containing the interferon stimulated responsive element (ISRE). In contrast, a construct containing the MHC class I-ISRE responsible for induction by IFN-beta in astrocytes was not responsive to IFN-beta in neurons. Therefore, transcription factor binding to the OAS- and MHC-ISREs was analyzed. While the OAS and MHC Class I site bound equal amounts of the transcriptional repressor IRF-2, the OAS-ISRE preferentially interacted with the transcriptional activator ISGF3 in response to IFN-beta. Further, unlike neurons, upregulation of MHC class I genes in astrocytes was related to binding of IRF-1 instead of IRF-2 to the MHC-ISRE. It is proposed that selective activation of anti-viral state genes compared to MHC class I genes by IFN-beta in neurons is mediated by preferential induction and binding of ISGF3 to anti-viral state gene ISREs but not the MHC-ISRE.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Massa PT,Whitney LW,Wu C,Ropka SL,Jarosinski KWdoi
10.3109/13550289909021998subject
Has Abstractpub_date
1999-04-01 00:00:00pages
161-71issue
2eissn
1355-0284issn
1538-2443journal_volume
5pub_type
杂志文章abstract::To verify the possibility of different role of JC virus genotypes in the etiology of progressive multifocal leukoencephalopathy, we analysed several JC virus isolates amplified from AIDS patients with and without progressive multifocal leukoencephalopathy and healthy controls by nucleotide sequencing. Cerebrospinal fl...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
doi:10.1080/135502801300069638
更新日期:2001-02-01 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is an inflammatory disease of the spinal cord and clinically characterized by progressive spastic paraparesis, urinary incontinence, and mild sen...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00881-w
更新日期:2020-10-01 00:00:00
abstract::Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study was carried out, comparing HIV-infected persons who had interrupted antiretroviral therapy in the pa...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550281003767710
更新日期:2010-05-01 00:00:00
abstract::Recent studies on the coreceptor usage of human immunodeficiency virus (HIV) strains associated with acquired immunodeficiency syndrome (AIDS) dementia have shown that both X4 and R5 viruses are involved in the process. The disease is associated with enhanced virus replication and monocyte chemoattractant protein (MCP...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/753312763
更新日期:2004-01-01 00:00:00
abstract::In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114225
更新日期:1998-12-01 00:00:00
abstract::Nipah virus is a recently emergent paramyxovirus that is capable of causing severe disease in both humans and animals. The first outbreak of Nipah virus occurred in Malaysia and Singapore in 1999 and, more recently, outbreaks were detected in Bangladesh. In humans, Nipah virus causes febrile encephalitis with respirat...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280500187435
更新日期:2005-10-01 00:00:00
abstract::Murine hepatitis virus A59 infection of the central nervous system (CNS) results in CNS demyelination in susceptible strains of mice. In infected B-cell-deficient mice, demyelination not only occurred but was also more severe than in parental C57BL/6 animals. This increase may be due to the persistence of virus in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280290049697
更新日期:2002-06-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0651-3
更新日期:2018-10-01 00:00:00
abstract::Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0293-z
更新日期:2014-12-01 00:00:00
abstract::Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported t...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280600654573
更新日期:2006-04-01 00:00:00
abstract::Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in people living with HIV. This effect was also observed in the central nervous system with the nowadays uncommon observation of dementias; yet in more recent works milder forms are still reported in 20-30% of optimally treated i...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00874-9
更新日期:2020-10-01 00:00:00
abstract::Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/BF03210846
更新日期:2010-11-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1)-associated neuropathogenesis occurs in a large minority of infected people. Presently, there are neither viral nor cellular markers that predict the development of brain disease during HIV-1 infection. This study was conducted to determine whether there exist systematic diff...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701510104
更新日期:2007-10-01 00:00:00
abstract::We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-017-0606-0
更新日期:2018-02-01 00:00:00
abstract::Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280802074539
更新日期:2008-08-01 00:00:00
abstract::Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0386-3
更新日期:2016-04-01 00:00:00
abstract::In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0097-y
更新日期:2012-06-01 00:00:00
abstract::Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein-Bar...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114547
更新日期:1998-08-01 00:00:00
abstract::Age-dependent poliomyelitis (ADPM) is a virally induced neuroparalytic disease of mice and a model for amyotrophic lateral sclerosis (ALS). ADPM is triggered in genetically susceptible mice by immunosuppression and infection with lactate dehydrogenase-elevating virus (LDV). Both ADPM and ALS are characterized by progr...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280152403308
更新日期:2001-06-01 00:00:00
abstract::Human immunodeficiency virus (HIV) has been implicated in neurological complications in developed countries. Developing countries have different viral clades and potentially different genetic and social risks for these complications. Baseline neurological performance measures associated with HIV infection have rarely ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280601169837
更新日期:2007-01-01 00:00:00
abstract::The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289709015807
更新日期:1997-04-01 00:00:00
abstract::A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an R...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00903-7
更新日期:2020-10-01 00:00:00
abstract::Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280390173319
更新日期:2003-02-01 00:00:00
abstract::Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111027
更新日期:1995-12-01 00:00:00
abstract::The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...
journal_title:Journal of neurovirology
pub_type: 已发布勘误
doi:10.1007/s13365-018-0637-1
更新日期:2018-06-01 00:00:00
abstract::Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0388-1
更新日期:2016-04-01 00:00:00
abstract::A recombinant adenovirus vector bearing the IL-4 gene (AD-IL-4) was used to infect rat glioma C6 cells in culture at multiplicity of infections (MOI) from 50 to 1800. C6 cell proliferation was not altered significantly by adenoviral infection. However, IL-4 production increased in a dose-dependent manner. To ascertain...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114523
更新日期:1998-04-01 00:00:00
abstract::Latent infection of sensory neurons and reactivation are necessary for maintenance of herpes simplex virus type 1 (HSV-1) in its host population. It has been proposed that the HSV-1 early gene, thymidine kinase (TK), may play an important regulatory role in this process. The authors used reporter transgenic mice to te...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490279771
更新日期:2004-04-01 00:00:00
abstract::The interplay between pathology and human immunodeficiency virus (HIV) expansion in brain tissues has not been thoroughly assessed in the highly active antiretroviral therapy (HAART) era. HIV-associated dementia (HAD) is marked by progressive brain infection due to recruitment and migration of macrophages in brain tis...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550281003735709
更新日期:2010-05-01 00:00:00