Abstract:
:The recent ability to quantitate and localize the interaction of antigen-specific T cells in the central nervous system during infectious and autoimmune diseases will greatly enhance our understanding of the molecular and biologic basis of virus-induced diseases of the nervous and other systems.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Oldstone MBdoi
10.1080/13550280490468438subject
Has Abstractpub_date
2004-08-01 00:00:00pages
207-15issue
4eissn
1355-0284issn
1538-2443pii
9HTN299K06LKX98Jjournal_volume
10pub_type
杂志文章,评审abstract::Human immunodeficiency virus (HIV) dementia remains as an important cause of neurological morbidity among HIV-seropositive (HIV+) individuals. Differences in the neuropsychological profiles between older and younger HIV+ individuals have not been examined extensively. The objective of this study was to examine the neu...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701258423
更新日期:2007-06-01 00:00:00
abstract::Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted inf...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280290100480
更新日期:2002-08-01 00:00:00
abstract::The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carria...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701802543
更新日期:2008-01-01 00:00:00
abstract::A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
doi:10.3109/13550280009006385
更新日期:2000-02-01 00:00:00
abstract::The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-018-0688-3
更新日期:2019-02-01 00:00:00
abstract::Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00843-2
更新日期:2020-10-01 00:00:00
abstract::To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590953825
更新日期:2005-07-01 00:00:00
abstract::Crack cocaine use is associated with impaired verbal memory in HIV-infected women more than uninfected women. To understand the neural basis for this impairment, this study examined the effects of crack cocaine use on activation of the prefrontal cortex (PFC) and strategic encoding during a verbal memory task in HIV-i...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0250-x
更新日期:2014-08-01 00:00:00
abstract::The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00782-7
更新日期:2020-02-01 00:00:00
abstract::Enteroviruses (EV) are responsible for a large number of meningoencephalitis cases, especially in children. The objective of this study was to identify modes of diagnosis including the significance of respiratory and cerebrospinal fluid samples, associated clinical characteristics, inpatient management, and outcome of...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00784-5
更新日期:2020-02-01 00:00:00
abstract::HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114537
更新日期:1998-08-01 00:00:00
abstract::Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein-Bar...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114547
更新日期:1998-08-01 00:00:00
abstract::The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00914-4
更新日期:2021-01-06 00:00:00
abstract::Over 65% of individuals infected with human immunodeficiency virus type 1 (HIV-1) reside in sub-Saharan Africa, and thus efforts to change the course of the HIV-1 pandemic should focus on this geographic region. Here, we discuss factors, including sexually transmitted diseases and hormonal contraceptive use, that impa...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280009091948
更新日期:2000-12-01 00:00:00
abstract::The most common complication of zoster in the elderly is postherpetic neuralgia, operationally defined as pain persisting longer than 1-2 months after rash. The cause of postherpetic neuralgia is unknown. Using polymerase chain reaction, we detected varicella zoster virus DNA in blood mononuclear cells from 11 of 51 p...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111018
更新日期:1995-03-01 00:00:00
abstract::The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...
journal_title:Journal of neurovirology
pub_type: 已发布勘误
doi:10.1007/s13365-018-0637-1
更新日期:2018-06-01 00:00:00
abstract::A monocenter observational study was conducted to determine the clinical and virological effects of cidofovir added to highly active anti-retroviral therapy (HAART) in AIDS-associated progressive multifocal leukoencephalopathy (PML). Exposure to other anti-viral drugs or late initiation of cidofovir were exclusion cri...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
doi:10.1080/13550280152537274
更新日期:2001-08-01 00:00:00
abstract::To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909015816
更新日期:1999-06-01 00:00:00
abstract::Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280390173319
更新日期:2003-02-01 00:00:00
abstract::The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0220-8
更新日期:2013-12-01 00:00:00
abstract::Viral factors responsible for HSV neurovirulence in humans are still unknown. The aim of this work was to investigate the hypothesis that viral variants might contribute to the specific neurovirulence of some HSV strains. HSV-1 DNA was recovered from cerebrospinal fluid (CSF) in ten patients with HSV encephalitis (HSE...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146892
更新日期:1996-08-01 00:00:00
abstract::Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the neurotropic human polyomavirus JC (JCV) lytic infection of oligodendrocytes. PML was first described as a complication of lymphoproliferative disorders more than 50 years ago and emerged as a major c...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-012-0080-7
更新日期:2012-02-01 00:00:00
abstract::With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00923-3
更新日期:2020-12-26 00:00:00
abstract::Age-dependent poliomyelitis (ADPM) is a virally induced neuroparalytic disease of mice and a model for amyotrophic lateral sclerosis (ALS). ADPM is triggered in genetically susceptible mice by immunosuppression and infection with lactate dehydrogenase-elevating virus (LDV). Both ADPM and ALS are characterized by progr...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280152403308
更新日期:2001-06-01 00:00:00
abstract::We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and b...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550281003682539
更新日期:2010-03-01 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is an inflammatory disease of the spinal cord and clinically characterized by progressive spastic paraparesis, urinary incontinence, and mild sen...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00881-w
更新日期:2020-10-01 00:00:00
abstract::Toscana virus (Bunyaviridae family, Phlebovirus genus) is a sandfly fever virus responsible for human neurological infections. Sandfly viruses are transmitted by insect vectors (Phlebotomus species) and the infection is present in climatic areas that allow the life cycle of the vector. The arthropode-borne Toscana vir...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280390247678
更新日期:2003-12-01 00:00:00
abstract::The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490441130
更新日期:2004-06-01 00:00:00
abstract::Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part o...
journal_title:Journal of neurovirology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13365-015-0352-0
更新日期:2015-10-01 00:00:00