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Association of long-term patterns of depressive symptoms and attention/executive function among older men with and without human immunodeficiency virus.

Abstract：

:Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV infection influenced the long-term effect of depression on attention/executive function. Responses to the Center for Epidemiologic Studies-Depression scale and attention/executive function tests (Trail Making Test Part B and Symbol Digit Modalities Test) were collected semiannually from May 1986 to April 2015 in 1611 men. Group-based trajectory models, stratified by HIV status, were used to identify latent patterns of depressive symptoms and attention/executive function across 12 years of follow-up. We identified three depression patterns for HIV-infected and HIV-uninfected men (rare/never 50.0 vs. 60.6%, periodically depressed 29.6 vs. 24.5%, chronic high 20.5 vs.15.0%, respectively) and three patterns of attention/executive function for HIV-infected and HIV-uninfected men (worst-performing 47.4 vs. 45.1%; average 41.9 vs. 47.0%; best-performing 10.7 vs. 8.0%, respectively). Multivariable logistic regression models were used to assess associations between depression patterns and worst-performing attention/executive function. Among HIV-uninfected men, those in the periodically depressed and chronic high depressed groups had higher odds of membership in the worst-performing attention/executive function group (adjusted odds ratio [AOR] = 1.45, 95% CI 1.04, 2.03; AOR = 2.25, 95% CI 1.49, 3.39, respectively). Among HIV-infected men, patterns of depression symptoms were not associated with patterns of attention/executive function. Results suggest that HIV-uninfected, but not HIV-infected, men with chronic high depression are more likely to experience a long-term pattern of attention/executive dysfunction.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Armstrong NM,Surkan PJ,Treisman GJ,Sacktor NC,Irwin MR,Teplin LA,Stall R,Martin EM,Becker JT,Munro C,Levine AJ,Jacobson LP,Abraham AG

doi

10.1007/s13365-017-0527-y

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

558-567

issue

eissn

1355-0284

issn

1538-2443

pii

10.1007/s13365-017-0527-y

journal_volume

pub_type

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Association of long-term patterns of depressive symptoms and attention/executive function among older men with and without human immunodeficiency virus.