Abstract：
:We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The pattern of expression of the transgene, studied at the RNA level by RT-PCR, was the same regardless of the origin of the promoter. The beta-galactosidase activity was detected primarily in the central nervous system, in the parenchyma, the choroid plexus and the ependymal cells along the ventricles. In parenchyma, double labelling experiments showed that the cells expressing beta-galactosidase were neurons. These results show that choroid plexus cells and ependymal cells, as well as some neurons, are permissive for the activity of the HTLV-I promoter. The origin of the LTR had not influence on the pattern of expression of the reporter gene.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Coscoy L,Gonzalez-Dunia D,Chirinian-Swan S,Brahic M,Ozden Sdoi
10.3109/13550289609146898subject
Has Abstractpub_date
1996-10-01 00:00:00pages
336-44issue
5eissn
1355-0284issn
1538-2443journal_volume
2pub_type
杂志文章abstract：:We report varicella-zoster virus (VZV) meningitis in a healthy adult woman with no antecedent rash and with hypoglycorrhachia. Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody. ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280902725550
更新日期：2009-04-01 00:00:00
abstract：:HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0279-x
更新日期：2014-12-01 00:00:00
abstract：:Over 65% of individuals infected with human immunodeficiency virus type 1 (HIV-1) reside in sub-Saharan Africa, and thus efforts to change the course of the HIV-1 pandemic should focus on this geographic region. Here, we discuss factors, including sexually transmitted diseases and hormonal contraceptive use, that impa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...
journal_title：Journal of neurovirology
pub_type： 杂志文章,多中心研究
doi：10.1007/s13365-014-0236-8
更新日期：2014-06-01 00:00:00
abstract：:Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0527-y
更新日期：2017-08-01 00:00:00
abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00838-z
更新日期：2020-06-01 00:00:00
abstract：:The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0557-5
更新日期：2017-10-01 00:00:00
abstract：:Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0388-1
更新日期：2016-04-01 00:00:00
abstract：:HIV viral proteins within the central nervous system are associated with the development of neurocognitive impairments in HIV-infected individuals. Dopamine transporter (DAT)-mediated dopamine transport is critical for normal dopamine homeostasis. Abnormal dopaminergic transmission has been implicated as a risk determ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0391-6
更新日期：2016-06-01 00:00:00
abstract：:Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.3109/13550289609146880
更新日期：1996-06-01 00:00:00
abstract：:To determine the possible influence of satellite glial cells on restricting the spread of herpes simplex virus in the peripheral nervous system, HSV replication was studied in clonally derived cultures of satellite glial cells from adult animals. Satellite cells were purified by exploiting their close anatomical assoc...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909029479
更新日期：1999-08-01 00:00:00
abstract：:Viral factors responsible for HSV neurovirulence in humans are still unknown. The aim of this work was to investigate the hypothesis that viral variants might contribute to the specific neurovirulence of some HSV strains. HSV-1 DNA was recovered from cerebrospinal fluid (CSF) in ten patients with HSV encephalitis (HSE...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289609146892
更新日期：1996-08-01 00:00:00
abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00848-x
更新日期：2020-08-01 00:00:00
abstract：:The interplay between pathology and human immunodeficiency virus (HIV) expansion in brain tissues has not been thoroughly assessed in the highly active antiretroviral therapy (HAART) era. HIV-associated dementia (HAD) is marked by progressive brain infection due to recruitment and migration of macrophages in brain tis...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550281003735709
更新日期：2010-05-01 00:00:00
abstract：:We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0606-0
更新日期：2018-02-01 00:00:00
abstract：:After uniocular anterior chamber (AC) inoculation of herpes simplex virus type 1 (HSV-1), virus and TNF alpha (TNF-alpha) are detected in the suprachiasmatic nuclei (SCN). The goal of this study was to investigate the role of TNF-alpha and macrophages in the brain of HSV-1-infected BALB/c mice. Mice were treated with ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280601039030
更新日期：2006-12-01 00:00:00
abstract：:This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot b...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280802448451
更新日期：2009-01-01 00:00:00
abstract：:Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289609146542
更新日期：1996-04-01 00:00:00
abstract：:The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant virus...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009018301
更新日期：2000-10-01 00:00:00
abstract：:Chemokines and their receptors are constitutively present in the central nervous system (CNS), expressed in neurons and glial cells. Much evidence suggests that, beyond their involvement in neuroinflammation, these proteins play a role in neurodevelopment and neurophysiological signaling. The goal of this review is to...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280290100932
更新日期：2002-12-01 00:00:00
abstract：:The entry of herpes simplex virus (HSV)-1 into cells is a complex process mediated in part by the binding of the HSV glycoprotein D (gD) to a specific cellular receptor identified as HveC, or nectin-1. We examined the distribution of HveC in sensory and motor neurons of the peripheral nervous system (PNS) by immunocyt...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/135502801753170336
更新日期：2001-10-01 00:00:00
abstract：:Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009015823
更新日期：2000-06-01 00:00:00
abstract：:In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909045382
更新日期：1999-10-01 00:00:00
abstract：:We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00760-z
更新日期：2019-12-01 00:00:00
abstract：:Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study was carried out, comparing HIV-infected persons who had interrupted antiretroviral therapy in the pa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550281003767710
更新日期：2010-05-01 00:00:00
abstract：:Development of multiple sclerosis (MS) is believed to involve genetic as well as environmental factors. A complicating aspect to the study of aetiological factors in MS concerns the possible existence of genetically different subtypes of the disease. In addition, a relatively large number of susceptibility genes could...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289609146904
更新日期：1996-12-01 00:00:00
abstract：:Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-016-0497-5
更新日期：2017-04-01 00:00:00
abstract：:A significant number of human immunodeficiency virus type 1 (HIV-1)-infected patients are alcoholics. Either alcohol or HIV alone induces morphological and functional damage to the nervous system. HIV-1 Tat is a potent transcriptional activator of the viral promoter, with the ability to modulate a number of cellular r...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280500516427
更新日期：2006-02-01 00:00:00
abstract：:The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00782-7
更新日期：2020-02-01 00:00:00
