Human immunodeficiency virus-1 evolutionary patterns associated with pathogenic processes in the brain.

abstract：:Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...

journal_title：Journal of neurovirology

authors： Nakamura R,Chong PF,Haraguchi K,Katano H,Tanaka-Taya K,Kira R

更新日期：2020-10-01 00:00:00

abstract：:We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and b...

journal_title：Journal of neurovirology

authors： Arslan F,Tabak F,Avşar E,Midilli K,Mert A,Ozaras R,Soysal T,Ozturk R,Ferhanoglu B

更新日期：2010-03-01 00:00:00

abstract：:Metabolic syndrome (MetS), a constellation of related metabolic risk factors, is a common comorbidity associated with cognitive difficulty in people living with HIV (PLWH). Neurobehavioral disturbances (e.g., behavioral manifestations of frontal-subcortical dysfunction) are also prevalent in HIV, yet the role MetS mig...

journal_title：Journal of neurovirology

authors： Pope CN,Montoya JL,Vasquez E,Pérez-Santiago J,Ellis R,McCutchan JA,Jeste DV,Moore DJ,Marquine MJ

更新日期：2020-12-01 00:00:00

abstract：:Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...

journal_title：Journal of neurovirology

authors： Kerr SJ,Armati PJ,Brew BJ

更新日期：1995-12-01 00:00:00

abstract：:The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant virus...

journal_title：Journal of neurovirology

authors： Morimoto K,Foley HD,McGettigan JP,Schnell MJ,Dietzschold B

更新日期：2000-10-01 00:00:00

abstract：:The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...

journal_title：Journal of neurovirology

authors： Cheeran MC,Gekker G,Hu S,Min X,Cox D,Lokensgard JR

更新日期：2004-06-01 00:00:00

abstract：:Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associated with ADC but their specific contri...

journal_title：Journal of neurovirology

authors： Smith KM,Crandall KA,Kneissl ML,Navia BA

更新日期：2000-04-01 00:00:00

abstract：:The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia...

journal_title：Journal of neurovirology

authors： Silva VP,Costa DS,Carvalho VCCVL,Garcês TCCS,Barros ELT,Oliveira JS,Pereira ACTC,Ferreira GP

更新日期：2020-02-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macrophages. Lack of remyelination has been attributed to insufficient pro...

journal_title：Journal of neurovirology

authors： Benner B,Martorell AJ,Mahadevan P,Najm FJ,Tesar PJ,Freundt EC

更新日期：2016-06-01 00:00:00

abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...

journal_title：Journal of neurovirology

authors： Hentzien M,Guihot A,de Maindreville D,Tabary T,Brodard V,Vieillard V,Adle-Biassette H,Bani-Sadr F

更新日期：2020-08-01 00:00:00

abstract：:The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...

journal_title：Journal of neurovirology

authors： Dos Santos DN,Sá KN,Queirós FC,Paixão AB,Santos KOB,de Andrade RCP,Camatti JR,Baptista AF

更新日期：2021-01-06 00:00:00

abstract：:To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...

journal_title：Journal of neurovirology

authors： Takemoto M,Kira R,Kusuhara K,Torisu H,Sakai Y,Hara T

更新日期：2005-07-01 00:00:00

abstract：:The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carria...

journal_title：Journal of neurovirology

authors： Itzhaki RF,Cosby SL,Wozniak MA

更新日期：2008-01-01 00:00:00

abstract：:Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study was carried out, comparing HIV-infected persons who had interrupted antiretroviral therapy in the pa...

journal_title：Journal of neurovirology

authors： Muñoz-Moreno JA,Fumaz CR,Prats A,Ferrer MJ,Negredo E,Pérez-Alvarez N,Moltó J,Gómez G,Garolera M,Clotet B

更新日期：2010-05-01 00:00:00

abstract：:We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospi...

journal_title：Journal of neurovirology

authors： Reddi A,Patel N,Morris NA

更新日期：2019-12-01 00:00:00

abstract：:Excessive glutamate neurotransmission has been implicated in neuronal injury in many disorders of the central nervous system (CNS), including human immunodeficiency virus (HIV)-associated dementia. Gp120IIIB is a strain of a HIV glycoprotein with specificity for the CXCR4 receptor that induces neuronal apoptosis in in...

journal_title：Journal of neurovirology

authors： Thomas AG,Bodner A,Ghadge G,Roos RP,Slusher BS

更新日期：2009-09-01 00:00:00

abstract：:Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivati...

journal_title：Journal of neurovirology

authors： Del Borgo C,Belvisi V,Valli MB,Currà A,Pozzetto I,Sepe M,Mastroianni CM

更新日期：2017-08-01 00:00:00

abstract：:Zimbabwe is a high prevalence area for HIV infection, and provides opportunities for studying complications of AIDS in both antiretroviral naive and treated groups of patients. Figures for HIV prevalence are among the highest in the world, but the number of people receiving treatment is very small. Economic and politi...

journal_title：Journal of neurovirology

authors： Mielke J

更新日期：2005-01-01 00:00:00

abstract：:When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

journal_title：Journal of neurovirology

authors： Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2004-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dement...

journal_title：Journal of neurovirology

authors： Gray LR,Gabuzda D,Cowley D,Ellett A,Chiavaroli L,Wesselingh SL,Churchill MJ,Gorry PR

更新日期：2011-02-01 00:00:00

abstract：:FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-...

journal_title：Journal of neurovirology

authors： Phillips TR,Prospero-Garcia O,Wheeler DW,Wagaman PC,Lerner DL,Fox HS,Whalen LR,Bloom FE,Elder JH,Henriksen SJ

更新日期：1996-12-01 00:00:00

abstract：:Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

journal_title：Journal of neurovirology

authors： Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

更新日期：2014-08-01 00:00:00

abstract：:HIV-associated neurocognitive disorder (HAND) is characterized by chronic immune activation. We aimed to identify biomarkers associated with HAND and to investigate their association with cognitive function and sex, in a homogenous cohort of HIV-infected (HIV+) young adults, parenterally infected during early childhoo...

journal_title：Journal of neurovirology

authors： Burlacu R,Umlauf A,Marcotte TD,Soontornniyomkij B,Diaconu CC,Bulacu-Talnariu A,Temereanca A,Ruta SM,Letendre S,Ene L,Achim CL

更新日期：2020-02-01 00:00:00

abstract：:The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...

journal_title：Journal of neurovirology

authors： Daep CA,Muñoz-Jordán JL,Eugenin EA

更新日期：2014-12-01 00:00:00

abstract：:Recent studies on the coreceptor usage of human immunodeficiency virus (HIV) strains associated with acquired immunodeficiency syndrome (AIDS) dementia have shown that both X4 and R5 viruses are involved in the process. The disease is associated with enhanced virus replication and monocyte chemoattractant protein (MCP...

journal_title：Journal of neurovirology

authors： Buch S,Sui Y,Potula R,Pinson D,Adany I,Li Z,Huang M,Li S,Dhillon N,Major E,Narayan O

更新日期：2004-01-01 00:00:00

abstract：:Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...

journal_title：Journal of neurovirology

authors： Sumner C,Shinohara T,Durham L,Traub R,Major EO,Amemiya K

更新日期：1996-04-01 00:00:00

abstract：:Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection. The appearance of viral RNA is particularly prominent in the cerebrospinal fluid (CSF), suggesting an efficient route of virus transfer across the blood-CSF...

journal_title：Journal of neurovirology

authors： Liu P,Hudson LC,Tompkins MB,Vahlenkamp TW,Colby B,Rundle C,Meeker RB

更新日期：2006-08-01 00:00:00

abstract：:Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part o...

journal_title：Journal of neurovirology

authors： Shikuma CM,Bennett K,Ananworanich J,Gerschenson M,Teeratakulpisarn N,Jadwattanakul T,DeGruttola V,McArthur JC,Ebenezer G,Chomchey N,Praihirunkit P,Hongchookiat P,Mathajittiphun P,Nakamoto B,Hauer P,Phanuphak P,Phanuphak N

更新日期：2015-10-01 00:00:00

abstract：:The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...

journal_title：Journal of neurovirology

authors： Geiser V,Jones C

更新日期：2005-12-01 00:00:00

abstract：:Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...

journal_title：Journal of neurovirology

authors： Weed MR,Hienz RD,Brady JV,Adams RJ,Mankowski JL,Clements JE,Zink MC

更新日期：2003-08-01 00:00:00