Abstract：
:We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and blood showed CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. Foscarnet resistance mutations were not found. Although therapy was switched to foscarnet when ganciclovir resistance was suspected, the patient was lost on posttransplant day 200.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Arslan F,Tabak F,Avşar E,Midilli K,Mert A,Ozaras R,Soysal T,Ozturk R,Ferhanoglu Bdoi
10.3109/13550281003682539subject
Has Abstractpub_date
2010-03-01 00:00:00pages
174-8issue
2eissn
1355-0284issn
1538-2443journal_volume
16pub_type
杂志文章abstract：:Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transform...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490499524
更新日期：2004-10-01 00:00:00
abstract：:A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly eleva...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00779-2
更新日期：2020-02-01 00:00:00
abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...
journal_title：Journal of neurovirology
pub_type：
doi：10.1007/s13365-015-0322-6
更新日期：2015-06-01 00:00:00
abstract：:Retroviral infection can induce transcriptional activation of genes flanking the sites of proviral integration in target cells. Because integration is essentially random, this phenomenon can be exploited for random mutagenesis of the genome, and analysis of integration sites in tumors may identify potential oncogenes....
journal_title：Journal of neurovirology
pub_type：
doi：10.1080/13550280152058834
更新日期：2001-04-01 00:00:00
abstract：:We report varicella-zoster virus (VZV) meningitis in a healthy adult woman with no antecedent rash and with hypoglycorrhachia. Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody. ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280902725550
更新日期：2009-04-01 00:00:00
abstract：:In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909045382
更新日期：1999-10-01 00:00:00
abstract：:Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-013-0221-7
更新日期：2013-12-01 00:00:00
abstract：:This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot b...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280802448451
更新日期：2009-01-01 00:00:00
abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00838-z
更新日期：2020-06-01 00:00:00
abstract：:Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0564-6
更新日期：2017-10-01 00:00:00
abstract：:The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-014-0285-z
更新日期：2014-12-01 00:00:00
abstract：:Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490521131
更新日期：2004-12-01 00:00:00
abstract：:A recombinant adenovirus vector bearing the IL-4 gene (AD-IL-4) was used to infect rat glioma C6 cells in culture at multiplicity of infections (MOI) from 50 to 1800. C6 cell proliferation was not altered significantly by adenoviral infection. However, IL-4 production increased in a dose-dependent manner. To ascertain...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809114523
更新日期：1998-04-01 00:00:00
abstract：:The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289709015807
更新日期：1997-04-01 00:00:00
abstract：:Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregates preferentially infected a microglia...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509113968
更新日期：1995-06-01 00:00:00
abstract：:Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein-Bar...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809114547
更新日期：1998-08-01 00:00:00
abstract：:The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00782-7
更新日期：2020-02-01 00:00:00
abstract：:AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009091948
更新日期：2000-12-01 00:00:00
abstract：:Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0368-5
更新日期：2016-02-01 00:00:00
abstract：:Infection of C57BL/6 mice with mouse hepatitis virus strain V5A13.1 (MHV-V5A13.1) results in an acute encephalitis followed by a chronic, progressive demyelinating disease with clinical and histological similarities to the human demyelinating disease Multiple Sclerosis (MS). Studies were undertaken to evaluate the con...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909029745
更新日期：1999-02-01 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0651-3
更新日期：2018-10-01 00:00:00
abstract：:Crack cocaine use is associated with impaired verbal memory in HIV-infected women more than uninfected women. To understand the neural basis for this impairment, this study examined the effects of crack cocaine use on activation of the prefrontal cortex (PFC) and strategic encoding during a verbal memory task in HIV-i...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0250-x
更新日期：2014-08-01 00:00:00
abstract：:Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investiga...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809113497
更新日期：1998-10-01 00:00:00
abstract：:The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant virus...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009018301
更新日期：2000-10-01 00:00:00
abstract：:Acute hemorrhagic leukoencephalitis (AHL) is a rare and usually fatal disorder characterized clinically by an acute onset of neurologic abnormalities. It may occur in association with a viral illness or vaccination. Radiology and brain biopsy are essential for the diagnosis. The etiology of AHL is unclear. We postulat...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280260422749
更新日期：2002-10-01 00:00:00
abstract：:In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-012-0097-y
更新日期：2012-06-01 00:00:00
abstract：:The interplay between pathology and human immunodeficiency virus (HIV) expansion in brain tissues has not been thoroughly assessed in the highly active antiretroviral therapy (HAART) era. HIV-associated dementia (HAD) is marked by progressive brain infection due to recruitment and migration of macrophages in brain tis...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550281003735709
更新日期：2010-05-01 00:00:00
abstract：:We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289709018297
更新日期：1997-06-01 00:00:00
abstract：:Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509111027
更新日期：1995-12-01 00:00:00
abstract：:The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible fo...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00817-z
更新日期：2020-04-01 00:00:00
