Abstract：
:A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly elevated protein but herpes simplex virus (HSV) polymerase chain reaction (PCR) was negative. A repeat CSF examination performed 9 days later showed a positive HSV PCR. Histopathological and immunohistochemical examination of autopsy specimen confirmed the presence of CD45+ lymphocytes and HSV antigen, suggesting the presence of both inflammation and viral infection corresponding to PET abnormality.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Singhal T,Solomon I,Akbik F,Smirnakis S,Vaitkevicius Hdoi
10.1007/s13365-019-00779-2subject
Has Abstractpub_date
2020-02-01 00:00:00pages
118-120issue
1eissn
1355-0284issn
1538-2443pii
10.1007/s13365-019-00779-2journal_volume
26pub_type
杂志文章abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00838-z
更新日期：2020-06-01 00:00:00
abstract：:Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.3109/13550289609146880
更新日期：1996-06-01 00:00:00
abstract：:Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-016-0497-5
更新日期：2017-04-01 00:00:00
abstract：:Cytomegalovirus (CMV) infection is an important cause of neurologic disease in the context of advanced human immunodeficiency virus (HIV) infection and is recognized as a cause of immune reconstitution inflammatory syndrome (IRIS) after initiation of highly active antiretroviral therapy (HAART). Central nervous system...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550281003735717
更新日期：2010-03-01 00:00:00
abstract：:JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390241269
更新日期：2003-10-01 00:00:00
abstract：:JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280590900391
更新日期：2005-02-01 00:00:00
abstract：:Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009015823
更新日期：2000-06-01 00:00:00
abstract：:Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0527-y
更新日期：2017-08-01 00:00:00
abstract：:The objective of this study was to assess lithium safety and tolerability and to explore its impact on cognition, function, and neuroimaging biomarkers in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. Fifteen cognitively impaired HIV-infected subjects were enrolled in this 10-week ope...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280902758973
更新日期：2009-04-01 00:00:00
abstract：:Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280152537175
更新日期：2001-08-01 00:00:00
abstract：:Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00843-2
更新日期：2020-10-01 00:00:00
abstract：:A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...
journal_title：Journal of neurovirology
pub_type： 临床试验,杂志文章
doi：10.3109/13550280009006385
更新日期：2000-02-01 00:00:00
abstract：:To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909015816
更新日期：1999-06-01 00:00:00
abstract：:This single-center study attempts to quantify the incidence of symptomatic CSF viral escape (CSFVE) in patients receiving atazanavir/r (ATV/r)-containing regimen. We performed a retrospective analysis of patients receiving ATV/r-containing ART who were diagnosed with symptomatic CSFVE from August 2012 to January 2017....
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0642-4
更新日期：2018-08-01 00:00:00
abstract：:Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0293-z
更新日期：2014-12-01 00:00:00
abstract：:With aging of HIV populations, there is concern that Alzheimer's disease (AD) may become prevalent and difficult to distinguish from HIV-associated neurocognitive disorders. To date, there are no reports documenting histologically verified Alzheimer's neuropathology in individuals with HIV and dementia. Herein, we rep...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0663-z
更新日期：2018-10-01 00:00:00
abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...
journal_title：Journal of neurovirology
pub_type：
doi：10.1007/s13365-015-0322-6
更新日期：2015-06-01 00:00:00
abstract：:Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289709015791
更新日期：1997-02-01 00:00:00
abstract：:Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-018-0614-8
更新日期：2018-06-01 00:00:00
abstract：:The neuromotor rehabilitative treatment should be joined in the global individualised project. The rehabilitation project is developed by an interdisciplinary. Hence, the clinicians have to promote an appropriate compensation process in the daily living activities with a rapid insertion of new or recovered motor-postu...
journal_title：Journal of neurovirology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2000-05-01 00:00:00
abstract：:Subacute sclerosing panencephalitis (SSPE) is a slowly progressive degenerative disorder caused by measles virus. It is characterised by typical clinical and electrophysiological features in the form of slow myoclonic jerks, with progressive cognitive impairment, visual symptoms, and periodic complexes on EEG, with ra...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0602-4
更新日期：2018-02-01 00:00:00
abstract：:We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for oth...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0419-y
更新日期：2016-08-01 00:00:00
abstract：:Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0257-3
更新日期：2014-08-01 00:00:00
abstract：:Human immunodeficiency virus type 1 (HIV-1)-associated neuropathogenesis occurs in a large minority of infected people. Presently, there are neither viral nor cellular markers that predict the development of brain disease during HIV-1 infection. This study was conducted to determine whether there exist systematic diff...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280701510104
更新日期：2007-10-01 00:00:00
abstract：:A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280701397627
更新日期：2007-08-01 00:00:00
abstract：:The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490441130
更新日期：2004-06-01 00:00:00
abstract：:Neurocognitive impairment (NCI) among HIV-infected patients is heterogeneous in its reported presentations and frequencies. To determine the prevalence of NCI and its associated subtypes as well as predictive variables, we investigated patients with HIV/AIDS receiving universal health care. Recruited adult HIV-infecte...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00791-6
更新日期：2020-02-01 00:00:00
abstract：:Although highly active antiretroviral therapy (HAART) has reduced the incidence of dementia, a significant proportion of HIV-infected individuals cease therapy because of unacceptable side effects. Further, HAART is not available to the majority of HIV-infected people worldwide. Thus, animal models remain an important...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280290101076
更新日期：2002-12-01 00:00:00
abstract：:Injection drug use has been recognized as a major risk factor for acquired immunodeficiency syndrome (AIDS) from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States, can both impair the functions of macrophages and CD4(+) lymphocytes and also activate human immunodeficiency vi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280701528684
更新日期：2007-12-01 00:00:00
abstract：:Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280601187177
更新日期：2007-04-01 00:00:00
