Abstract：
:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has been reported in peripheral blood. This study aims to explore the expression level of the adhesion molecule during the expression level of the adhesion molecule among HAM/TSP disease activity. In lymphocyte function-associated antigen 1 and DNAX accessory molecule 1, no variation in expression levels specific to HTLV-1 infection was observed in CD4-positive T cells; however, TSLC1 expression was higher in HAM patients than in asymptomatic carriers and non-infected persons. TSLC1 tended to be higher in patients whose symptoms were worsening. On the contrary, the expression level of TSLC1 in CD8-positive T cells was lower in HAM patients than in asymptomatic carriers, and this tendency was stronger in patients whose symptoms had deteriorated. No significant correlation was found between TSLC1 and either of the transcription factors Tax or HBZ in any T cell group. Therefore, TSLC1 expression in CD4-positive T cells might be a useful biomarker of HAM/TSP disease activity.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Takenouchi N,Tanaka M,Sato T,Yao J,Fujisawa JI,Izumo S,Kubota R,Matsuura Edoi
10.1007/s13365-020-00838-zsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
404-414issue
3eissn
1355-0284issn
1538-2443pii
10.1007/s13365-020-00838-zjournal_volume
26pub_type
杂志文章abstract：:Retroviral infection can induce transcriptional activation of genes flanking the sites of proviral integration in target cells. Because integration is essentially random, this phenomenon can be exploited for random mutagenesis of the genome, and analysis of integration sites in tumors may identify potential oncogenes....
journal_title：Journal of neurovirology
pub_type：
doi：10.1080/13550280152058834
更新日期：2001-04-01 00:00:00
abstract：:Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-014-0271-5
更新日期：2015-06-01 00:00:00
abstract：:Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390218751
更新日期：2003-08-01 00:00:00
abstract：:Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-013-0221-7
更新日期：2013-12-01 00:00:00
abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease affecting the central nervous system as a result of reactivation of the John Cunningham (JC) polyomavirus and occurs almost exclusively in immunosuppressed individuals. The disease course of PML is variable but usually progressive and often fa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00899-0
更新日期：2020-12-01 00:00:00
abstract：:Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289709015791
更新日期：1997-02-01 00:00:00
abstract：:HIV-associated neurocognitive disorder (HAND) is characterized by chronic immune activation. We aimed to identify biomarkers associated with HAND and to investigate their association with cognitive function and sex, in a homogenous cohort of HIV-infected (HIV+) young adults, parenterally infected during early childhoo...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00785-4
更新日期：2020-02-01 00:00:00
abstract：:Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dement...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-010-0001-6
更新日期：2011-02-01 00:00:00
abstract：:To determine the possible influence of satellite glial cells on restricting the spread of herpes simplex virus in the peripheral nervous system, HSV replication was studied in clonally derived cultures of satellite glial cells from adult animals. Satellite cells were purified by exploiting their close anatomical assoc...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909029479
更新日期：1999-08-01 00:00:00
abstract：:Human immunodeficiency virus type 1 (HIV-1)-associated neuropathogenesis occurs in a large minority of infected people. Presently, there are neither viral nor cellular markers that predict the development of brain disease during HIV-1 infection. This study was conducted to determine whether there exist systematic diff...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280701510104
更新日期：2007-10-01 00:00:00
abstract：:JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280590900391
更新日期：2005-02-01 00:00:00
abstract：:Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection. The appearance of viral RNA is particularly prominent in the cerebrospinal fluid (CSF), suggesting an efficient route of virus transfer across the blood-CSF...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280600889567
更新日期：2006-08-01 00:00:00
abstract：:An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0632-6
更新日期：2018-08-01 00:00:00
abstract：:A neuroinvasive/neuropathogenic SIV variant termed SIVmac182 was previously isolated and characterized (Watry et al, 1994). This neuroinvasive strain was derived from the uncloned strain SIVmac251 through serial animal passage of infected microglia, unlike previously reported neurovirulent strains. Importantly, the vi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809114528
更新日期：1998-06-01 00:00:00
abstract：:Neurodegeneration and human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are the major disease manifestations of HIV-1 colonization of the central nervous system (CNS). In the brain, HIV-1 replicates in microglial cells and infiltrating macrophages and it persists in a low-productive, noncytolytic s...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390201263
更新日期：2003-06-01 00:00:00
abstract：:Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly eleva...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00779-2
更新日期：2020-02-01 00:00:00
abstract：:Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/BF03210846
更新日期：2010-11-01 00:00:00
abstract：:In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809114225
更新日期：1998-12-01 00:00:00
abstract：:The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carria...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280701802543
更新日期：2008-01-01 00:00:00
abstract：:In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909045382
更新日期：1999-10-01 00:00:00
abstract：:Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280290049534
更新日期：2002-04-01 00:00:00
abstract：:In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280591002405
更新日期：2005-08-01 00:00:00
abstract：:Over the past decade there has been a revolution in the understanding and care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-associated disease. Much of this progress stems from a broader recognition of the importance of differences in viral types, including receptor preference(s), repl...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280590922838
更新日期：2005-04-01 00:00:00
abstract：:In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-012-0097-y
更新日期：2012-06-01 00:00:00
abstract：:The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant virus...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009018301
更新日期：2000-10-01 00:00:00
abstract：:Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0388-1
更新日期：2016-04-01 00:00:00
abstract：:We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00760-z
更新日期：2019-12-01 00:00:00
abstract：:Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted inf...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280290100480
更新日期：2002-08-01 00:00:00
abstract：:In the era of the AIDS pandemic, progressive multifocal leukoencephalopathy (PML) has ceased being a rare disease. Prevalence estimates from clinical and pathological series suggest that up to 5% of all HIV-infected persons will develop PML. The extraordinary frequency with which PML attends HIV infection vastly excee...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280390195261
更新日期：2003-01-01 00:00:00
