Abstract：
:To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The other antibodies, raised against overlapping peptides close to two glycosylation sites, did not recognize PrPSc-mouse but did recognize PrPSc-sheep which contains two sugar residues and PrPCJD with or without a sugar residue. Our results suggest that these antibodies may have species-specificity for both glycosylation status and amino acid sequences of the protein. In conclusion, we identified two regions in bovine-PrP which appear suitable for raising antibodies that detect various kinds of PrPs, and one region (Ab103-121) which appears suitable for raising antibodies that detect several species of PrPs. These antibodies may be useful for diagnosing prion diseases and for researching their pathogenesis.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Takahashi H,Takahashi RH,Hasegawa H,Horiuchi M,Shinagawa M,Yokoyama T,Kimura K,Haritani M,Kurata T,Nagashima Kdoi
10.3109/13550289909015816subject
Has Abstractpub_date
1999-06-01 00:00:00pages
300-7issue
3eissn
1355-0284issn
1538-2443journal_volume
5pub_type
杂志文章abstract：:Over 65% of individuals infected with human immunodeficiency virus type 1 (HIV-1) reside in sub-Saharan Africa, and thus efforts to change the course of the HIV-1 pandemic should focus on this geographic region. Here, we discuss factors, including sexually transmitted diseases and hormonal contraceptive use, that impa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280600827351
更新日期：2006-06-01 00:00:00
abstract：:Human immunodeficiency virus (HIV) dementia remains as an important cause of neurological morbidity among HIV-seropositive (HIV+) individuals. Differences in the neuropsychological profiles between older and younger HIV+ individuals have not been examined extensively. The objective of this study was to examine the neu...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280701258423
更新日期：2007-06-01 00:00:00
abstract：:The most common complication of zoster in the elderly is postherpetic neuralgia, operationally defined as pain persisting longer than 1-2 months after rash. The cause of postherpetic neuralgia is unknown. Using polymerase chain reaction, we detected varicella zoster virus DNA in blood mononuclear cells from 11 of 51 p...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509111018
更新日期：1995-03-01 00:00:00
abstract：:Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure E...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00891-8
更新日期：2020-12-01 00:00:00
abstract：:Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-016-0497-5
更新日期：2017-04-01 00:00:00
abstract：:Recent studies on the coreceptor usage of human immunodeficiency virus (HIV) strains associated with acquired immunodeficiency syndrome (AIDS) dementia have shown that both X4 and R5 viruses are involved in the process. The disease is associated with enhanced virus replication and monocyte chemoattractant protein (MCP...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/753312763
更新日期：2004-01-01 00:00:00
abstract：:Neurodegeneration and human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are the major disease manifestations of HIV-1 colonization of the central nervous system (CNS). In the brain, HIV-1 replicates in microglial cells and infiltrating macrophages and it persists in a low-productive, noncytolytic s...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390201263
更新日期：2003-06-01 00:00:00
abstract：:Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the s...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0239-5
更新日期：2014-06-01 00:00:00
abstract：:Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-018-0614-8
更新日期：2018-06-01 00:00:00
abstract：:Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280152537175
更新日期：2001-08-01 00:00:00
abstract：:Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transform...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490499524
更新日期：2004-10-01 00:00:00
abstract：:Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/BF03210846
更新日期：2010-11-01 00:00:00
abstract：:The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,多中心研究
doi：10.1007/s13365-018-0688-3
更新日期：2019-02-01 00:00:00
abstract：:Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280290049534
更新日期：2002-04-01 00:00:00
abstract：:Herpes simplex encephalitis relapses have been rarely reported, with only few cases occurring after neurosurgical interventions. A young man presented a late herpes simplex encephalitis relapse after left antero-mesial temporal resection for his refractory temporal lobe epilepsy. Eight days after surgery, he developed...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00796-1
更新日期：2020-02-01 00:00:00
abstract：:HIV-associated neurocognitive disorders (HANDs) continue to be common and are associated with increased morbidity and mortality. However, the underlying mechanisms in the combination antiretroviral therapy (cART) era are not fully understood. Interferon alpha (IFNα) is an antiviral cytokine found to be elevated in the...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-016-0466-z
更新日期：2017-02-01 00:00:00
abstract：:The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490441130
更新日期：2004-06-01 00:00:00
abstract：:A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an R...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-020-00903-7
更新日期：2020-10-01 00:00:00
abstract：:Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490521131
更新日期：2004-12-01 00:00:00
abstract：:Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associated with ADC but their specific contri...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009013160
更新日期：2000-04-01 00:00:00
abstract：:Clinical or laboratory evidence of varicella-zoster virus (VZV) infection has been consistently associated with lower glioma risk in case-control studies, suggesting a protective effect of VZV against glioma. We formulated the following explanatory hypotheses: reactivated VZV preferentially infects and kills gliomas c...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-011-0048-z
更新日期：2011-10-01 00:00:00
abstract：:In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809114225
更新日期：1998-12-01 00:00:00
abstract：:AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009091948
更新日期：2000-12-01 00:00:00
abstract：:B-lymphoblastoid cell-lines may develop spontaneously in mononuclear cells from patients with multiple sclerosis, an observation rarely seen in healthy individuals. Examination of such spontaneously established B-cell lines reveal the presence of Epstein-Barr virus and retrovirus particles. We have speculated that in ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00843-2
更新日期：2020-10-01 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19), first reported in Wuhan, the capital of Hubei, China, has been associated to a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In March 2020, the World Health Organization declared the SARS-CoV-2 infection a global pandemic. Soon after, the numb...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-020-00862-z
更新日期：2020-06-01 00:00:00
abstract：:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280600975358
更新日期：2006-10-01 00:00:00
abstract：:Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0293-z
更新日期：2014-12-01 00:00:00
abstract：:We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0717-2
更新日期：2019-06-01 00:00:00
