Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls.

Abstract:

:The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible for encephalitis in immunocompetent individuals (e.g., VZV, enterovirus). A blood sample for the calculation of the CSF/blood replication ratio was collected in 74% of cases. CSF cultures and immunophenotyping of CSF cells were performed in 77% and 21% of patients, respectively. A multidisciplinary consensus is needed to improve current guidelines and standardize diagnostic protocols.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Vegezzi E,Berzero G,Barbetta D,Colombo AA,Borsani O,Bernasconi P,Compagno F,Zecca M,Campanini G,Simoncelli A,Paoletti M,Pichiecchio A,Baldanti F,Brunetti E,Marchioni E

doi

10.1007/s13365-019-00817-z

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

257-263

issue

2

eissn

1355-0284

issn

1538-2443

pii

10.1007/s13365-019-00817-z

journal_volume

26

pub_type

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