Abstract:
:The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia in Brazil. The occurrence was found of peripheral polyneuropathy affecting the upper and lower limbs evidenced by electroneuromyographic findings. The patient was treated with a corticoid associated with methotrexate, suggesting that the pathophysiological basis of the case in question may be related to an immune-mediated response by T cells and inflammatory cytokines. This finding reinforces the need to be aware of the emergence of neuroinfections related to CHIKV and effective diagnoses for the early detection of neurological alterations, favoring the clinical management of these patients.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Silva VP,Costa DS,Carvalho VCCVL,Garcês TCCS,Barros ELT,Oliveira JS,Pereira ACTC,Ferreira GPdoi
10.1007/s13365-019-00782-7subject
Has Abstractpub_date
2020-02-01 00:00:00pages
122-126issue
1eissn
1355-0284issn
1538-2443pii
10.1007/s13365-019-00782-7journal_volume
26pub_type
杂志文章abstract::Metabolic syndrome (MetS), a constellation of related metabolic risk factors, is a common comorbidity associated with cognitive difficulty in people living with HIV (PLWH). Neurobehavioral disturbances (e.g., behavioral manifestations of frontal-subcortical dysfunction) are also prevalent in HIV, yet the role MetS mig...
journal_title:Journal of neurovirology
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abstract::The neuromotor rehabilitative treatment should be joined in the global individualised project. The rehabilitation project is developed by an interdisciplinary. Hence, the clinicians have to promote an appropriate compensation process in the daily living activities with a rapid insertion of new or recovered motor-postu...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-05-01 00:00:00
abstract::To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590953825
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00746-x
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abstract::Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the s...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0239-5
更新日期:2014-06-01 00:00:00
abstract::HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0279-x
更新日期:2014-12-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550281003682539
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abstract::An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0632-6
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280802074539
更新日期:2008-08-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0388-1
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280903131923
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-016-0497-5
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0320-8
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280152403308
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abstract::The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-018-0688-3
更新日期:2019-02-01 00:00:00
abstract::A recombinant adenovirus vector bearing the IL-4 gene (AD-IL-4) was used to infect rat glioma C6 cells in culture at multiplicity of infections (MOI) from 50 to 1800. C6 cell proliferation was not altered significantly by adenoviral infection. However, IL-4 production increased in a dose-dependent manner. To ascertain...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114523
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280500516427
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00848-x
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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abstract::Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
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abstract::In the highly active antiretroviral therapy (HAART) era, the role of the inflammatory response in acquired immunodeficiency syndrome (AIDS)-related progressive multifocal leukoencephalopathy (PML) remains controversial. In this study, JC virus DNA load and levels of cytokines were determined in cerebrospinal fluid (CS...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590924539
更新日期:2005-04-01 00:00:00
abstract::On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...
journal_title:Journal of neurovirology
pub_type:
doi:10.1007/s13365-015-0322-6
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abstract::Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.3109/13550289609146880
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abstract::Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146542
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abstract::Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
abstract::Development of multiple sclerosis (MS) is believed to involve genetic as well as environmental factors. A complicating aspect to the study of aetiological factors in MS concerns the possible existence of genetically different subtypes of the disease. In addition, a relatively large number of susceptibility genes could...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
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