Peripheral polyneuropathy associated with Chikungunya virus infection.

Abstract:

:The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia in Brazil. The occurrence was found of peripheral polyneuropathy affecting the upper and lower limbs evidenced by electroneuromyographic findings. The patient was treated with a corticoid associated with methotrexate, suggesting that the pathophysiological basis of the case in question may be related to an immune-mediated response by T cells and inflammatory cytokines. This finding reinforces the need to be aware of the emergence of neuroinfections related to CHIKV and effective diagnoses for the early detection of neurological alterations, favoring the clinical management of these patients.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Silva VP,Costa DS,Carvalho VCCVL,Garcês TCCS,Barros ELT,Oliveira JS,Pereira ACTC,Ferreira GP

doi

10.1007/s13365-019-00782-7

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

122-126

issue

1

eissn

1355-0284

issn

1538-2443

pii

10.1007/s13365-019-00782-7

journal_volume

26

pub_type

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