Abstract:
:The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and Culex spp.), traveling within endemic areas, rapid adaptation of the insects into new geographic locations, climate change, and lack of medical surveillance have greatly contributed to the increase in flaviviral infections worldwide. The mechanisms by which flaviviruses alter the immune and the central nervous system have only recently been examined despite the alarming number of infections, related deaths, and increasing global distribution. In this review, we will discuss the expansion of the geographic areas affected by flaviviruses, the potential threats to previously unaffected countries, the mechanisms of pathogenesis, and the potential therapeutic interventions to limit the devastating consequences of these viruses.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Daep CA,Muñoz-Jordán JL,Eugenin EAdoi
10.1007/s13365-014-0285-zsubject
Has Abstractpub_date
2014-12-01 00:00:00pages
539-60issue
6eissn
1355-0284issn
1538-2443journal_volume
20pub_type
杂志文章,评审abstract::Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...
journal_title:Journal of neurovirology
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abstract::Rapid maturation of major white matter pathways occurs in the first 2 years of life, indicating a critical neuronal developmental period. The impact of initiating antiretroviral therapy (ART) in children perinatally infected with HIV-1, after the age of 2 years on neurocognitive functioning and white matter developmen...
journal_title:Journal of neurovirology
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abstract::Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...
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journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-018-0614-8
更新日期:2018-06-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-011-0048-z
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abstract::Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...
journal_title:Journal of neurovirology
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doi:10.1080/13550280390173319
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280601169837
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111018
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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doi:10.3109/13550281003735717
更新日期:2010-03-01 00:00:00
abstract::In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909045382
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journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280802448451
更新日期:2009-01-01 00:00:00
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journal_title:Journal of neurovirology
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doi:10.1080/13550280600654573
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journal_title:Journal of neurovirology
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doi:10.3109/13550289609146892
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0386-3
更新日期:2016-04-01 00:00:00
abstract::The entry of herpes simplex virus (HSV)-1 into cells is a complex process mediated in part by the binding of the HSV glycoprotein D (gD) to a specific cellular receptor identified as HveC, or nectin-1. We examined the distribution of HveC in sensory and motor neurons of the peripheral nervous system (PNS) by immunocyt...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/135502801753170336
更新日期:2001-10-01 00:00:00
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journal_title:Journal of neurovirology
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doi:10.1007/s13365-013-0221-7
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abstract::Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study was carried out, comparing HIV-infected persons who had interrupted antiretroviral therapy in the pa...
journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280009013160
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abstract::There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...
journal_title:Journal of neurovirology
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
abstract::In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...
journal_title:Journal of neurovirology
pub_type: 杂志文章
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abstract::Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted inf...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280290100480
更新日期:2002-08-01 00:00:00
abstract::Human immunodeficiency virus (HIV) dementia remains as an important cause of neurological morbidity among HIV-seropositive (HIV+) individuals. Differences in the neuropsychological profiles between older and younger HIV+ individuals have not been examined extensively. The objective of this study was to examine the neu...
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journal_title:Journal of neurovirology
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abstract::The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...
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