Abstract:
:This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot be studied with "Mendelian genetics" concepts only. They also display complex interactions with other HERV families, and with classical viruses. These concepts may contribute to unravelling the etiopathogenesis of complex diseases such as multiple sclerosis, schizophrenia, and other chronic multifactorial diseases.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Dolei A,Perron Hdoi
10.1080/13550280802448451subject
Has Abstractpub_date
2009-01-01 00:00:00pages
4-13issue
1eissn
1355-0284issn
1538-2443pii
906061465journal_volume
15pub_type
杂志文章,评审abstract::Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289709015791
更新日期:1997-02-01 00:00:00
abstract::The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00730-5
更新日期:2019-06-01 00:00:00
abstract::The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289709015807
更新日期:1997-04-01 00:00:00
abstract::Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0293-z
更新日期:2014-12-01 00:00:00
abstract::Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111027
更新日期:1995-12-01 00:00:00
abstract::Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146542
更新日期:1996-04-01 00:00:00
abstract::Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/BF03210846
更新日期:2010-11-01 00:00:00
abstract::Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-016-0497-5
更新日期:2017-04-01 00:00:00
abstract::There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00746-x
更新日期:2019-08-01 00:00:00
abstract::With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00923-3
更新日期:2020-12-26 00:00:00
abstract::HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0135-9
更新日期:2013-02-01 00:00:00
abstract::To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909015816
更新日期:1999-06-01 00:00:00
abstract::Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0221-7
更新日期:2013-12-01 00:00:00
abstract::The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909021298
更新日期:1999-12-01 00:00:00
abstract::Acute hemorrhagic leukoencephalitis (AHL) is a rare and usually fatal disorder characterized clinically by an acute onset of neurologic abnormalities. It may occur in association with a viral illness or vaccination. Radiology and brain biopsy are essential for the diagnosis. The etiology of AHL is unclear. We postulat...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280260422749
更新日期:2002-10-01 00:00:00
abstract::In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114225
更新日期:1998-12-01 00:00:00
abstract::Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pr...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-010-0006-1
更新日期:2011-02-01 00:00:00
abstract::Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.3109/13550289609146880
更新日期:1996-06-01 00:00:00
abstract::Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0257-3
更新日期:2014-08-01 00:00:00
abstract::Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280600975358
更新日期:2006-10-01 00:00:00
abstract::Zimbabwe is a high prevalence area for HIV infection, and provides opportunities for studying complications of AIDS in both antiretroviral naive and treated groups of patients. Figures for HIV prevalence are among the highest in the world, but the number of people receiving treatment is very small. Economic and politi...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280500511766
更新日期:2005-01-01 00:00:00
abstract::Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of hu...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00822-2
更新日期:2020-06-01 00:00:00
abstract::A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
doi:10.3109/13550280009006385
更新日期:2000-02-01 00:00:00
abstract::It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma i...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transform...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490499524
更新日期:2004-10-01 00:00:00
abstract::HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114537
更新日期:1998-08-01 00:00:00
abstract::Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-014-0236-8
更新日期:2014-06-01 00:00:00
abstract::Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investiga...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809113497
更新日期:1998-10-01 00:00:00
abstract::Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280390218751
更新日期:2003-08-01 00:00:00
abstract::Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0151-4
更新日期:2013-04-01 00:00:00