Abstract:
:Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of human PRV encephalitis diagnosed by the next-generation sequencing (NGS) of PRV sequences in the cerebrospinal fluid (CSF) of a patient. A male pork vendor developed fever and seizures for 6 days. NGS results showed PRV sequences in his CSF and blood. Sanger sequencing showed that PRV DNA in the CSF and PRV antibodies in both the CSF and blood were positive. MRI results revealed multiple inflammatory lesions in the bilateral hemisphere. Based on the clinical and laboratory data, we diagnosed the patient with PRV encephalitis. This case suggests that PRV can infect humans, causing severe viral encephalitis. People at risk of PRV infection should improve their self-protection awareness.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Wang D,Tao X,Fei M,Chen J,Guo W,Li P,Wang Jdoi
10.1007/s13365-019-00822-2subject
Has Abstractpub_date
2020-06-01 00:00:00pages
442-448issue
3eissn
1355-0284issn
1538-2443pii
10.1007/s13365-019-00822-2journal_volume
26pub_type
杂志文章abstract::Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0221-7
更新日期:2013-12-01 00:00:00
abstract::Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregates preferentially infected a microglia...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509113968
更新日期:1995-06-01 00:00:00
abstract::To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909015816
更新日期:1999-06-01 00:00:00
abstract::Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported t...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280600654573
更新日期:2006-04-01 00:00:00
abstract::Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.3109/13550289609146880
更新日期:1996-06-01 00:00:00
abstract::Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0386-3
更新日期:2016-04-01 00:00:00
abstract::We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289709018297
更新日期:1997-06-01 00:00:00
abstract::The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carria...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701802543
更新日期:2008-01-01 00:00:00
abstract::Chemokines influence HIV neuropathogenesis by affecting the HIV life cycle, trafficking of macrophages into the nervous system, glial activation, and neuronal signaling and repair processes; however, knowledge of their relationship to in vivo measures of cerebral injury is limited. The primary objective of this study ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-010-0013-2
更新日期:2011-02-01 00:00:00
abstract::Chemokines and their receptors are constitutively present in the central nervous system (CNS), expressed in neurons and glial cells. Much evidence suggests that, beyond their involvement in neuroinflammation, these proteins play a role in neurodevelopment and neurophysiological signaling. The goal of this review is to...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290100932
更新日期:2002-12-01 00:00:00
abstract::Epstein-Barr virus (EBV) associated central nervous system (CNS) infection is a rare disease. We report an atypical manifestation of EBV encephalitis initially presenting with a tumor-like lesion of the optic tract in an immunocompromised patient 8 years after a combined kidney and pancreas transplantation had been pe...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802345715
更新日期:2008-11-01 00:00:00
abstract::The interplay between pathology and human immunodeficiency virus (HIV) expansion in brain tissues has not been thoroughly assessed in the highly active antiretroviral therapy (HAART) era. HIV-associated dementia (HAD) is marked by progressive brain infection due to recruitment and migration of macrophages in brain tis...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550281003735709
更新日期:2010-05-01 00:00:00
abstract::Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0293-z
更新日期:2014-12-01 00:00:00
abstract::We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-017-0606-0
更新日期:2018-02-01 00:00:00
abstract::Excessive glutamate neurotransmission has been implicated in neuronal injury in many disorders of the central nervous system (CNS), including human immunodeficiency virus (HIV)-associated dementia. Gp120IIIB is a strain of a HIV glycoprotein with specificity for the CXCR4 receptor that induces neuronal apoptosis in in...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280903350598
更新日期:2009-09-01 00:00:00
abstract::The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0285-z
更新日期:2014-12-01 00:00:00
abstract::Our previous studies in an experimental model of rabies showed neuronal process degeneration in association with severe clinical disease. Cultured adult rodent dorsal root ganglion neurons infected with challenge virus standard (CVS)-11 strain of rabies virus (RABV) showed axonal swellings and reduced axonal growth wi...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0320-8
更新日期:2015-08-01 00:00:00
abstract::Retroviral infection can induce transcriptional activation of genes flanking the sites of proviral integration in target cells. Because integration is essentially random, this phenomenon can be exploited for random mutagenesis of the genome, and analysis of integration sites in tumors may identify potential oncogenes....
journal_title:Journal of neurovirology
pub_type:
doi:10.1080/13550280152058834
更新日期:2001-04-01 00:00:00
abstract::Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802105002
更新日期:2008-05-01 00:00:00
abstract::The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0220-8
更新日期:2013-12-01 00:00:00
abstract::Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.3109/13550289809113490
更新日期:1998-02-01 00:00:00
abstract::HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0279-x
更新日期:2014-12-01 00:00:00
abstract::Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280601187177
更新日期:2007-04-01 00:00:00
abstract::The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280500385286
更新日期:2005-12-01 00:00:00
abstract::Clinical or laboratory evidence of varicella-zoster virus (VZV) infection has been consistently associated with lower glioma risk in case-control studies, suggesting a protective effect of VZV against glioma. We formulated the following explanatory hypotheses: reactivated VZV preferentially infects and kills gliomas c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-011-0048-z
更新日期:2011-10-01 00:00:00
abstract::Neurocognitive impairment (NCI) among HIV-infected patients is heterogeneous in its reported presentations and frequencies. To determine the prevalence of NCI and its associated subtypes as well as predictive variables, we investigated patients with HIV/AIDS receiving universal health care. Recruited adult HIV-infecte...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00791-6
更新日期:2020-02-01 00:00:00
abstract::Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0271-5
更新日期:2015-06-01 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00838-z
更新日期:2020-06-01 00:00:00
abstract::Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the neurotropic human polyomavirus JC (JCV) lytic infection of oligodendrocytes. PML was first described as a complication of lymphoproliferative disorders more than 50 years ago and emerged as a major c...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-012-0080-7
更新日期:2012-02-01 00:00:00