Trail Making Test A improves performance characteristics of the International HIV Dementia Scale to identify symptomatic HAND.

Abstract:

:Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand for the identification of symptomatic HAND, defined as both HAD and mild neurocognitive disorder. We then sought to determine if adding a simple test from a larger neuropsychological battery could improve the performance characteristics for identifying symptomatic HAND. In this study, subjects comprising 75 seropositive adults in Bangkok, Thailand, completed neuropsychological tests and underwent a full neurological assessment. HAND diagnoses were determined by consensus conference using the 2007 Frascati criteria, blinded to the IHDS results. The optimal IHDS cut point was determined by receiver operating characteristic analysis with cross-validation. Individual neuropsychological tests were then evaluated and combined with the IHDS to test performance characteristics. The IHDS was poor at detecting symptomatic HAND at the optimized cut point of ≤ 10 (sensitivity, 53.3 %; specificity, 89.8 %). Trail Making Test A was most effective in improving performance characteristics when combined with the IHDS, with net sensitivity of 86 % and specificity of 79 %. In this setting, the IHDS performed poorly in identifying symptomatic HAND, but was substantially improved by the addition of Trail Making Test A, which typically requires less than 2 min to complete. This combination should be validated in a larger setting since it may address the critical need for HAND screening instruments in international settings.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Chalermchai T,Valcour V,Sithinamsuwan P,Pinyakorn S,Clifford D,Paul RH,Tipsuk S,Fletcher JL,Degruttola V,Ratto-Kim S,Hutchings N,Shikuma C,Ananworanich J,SEARCH 007 and 011 study groups.

doi

10.1007/s13365-013-0151-4

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

137-43

issue

2

eissn

1355-0284

issn

1538-2443

journal_volume

19

pub_type

杂志文章
  • HIV eradication symposium: will the brain be left behind?

    abstract::On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...

    journal_title:Journal of neurovirology

    pub_type:

    doi:10.1007/s13365-015-0322-6

    authors: Brew BJ,Robertson K,Wright EJ,Churchill M,Crowe SM,Cysique LA,Deeks S,Garcia JV,Gelman B,Gray LR,Johnson T,Joseph J,Margolis DM,Mankowski JL,Spencer B

    更新日期:2015-06-01 00:00:00

  • Characterization of antibodies raised against bovine-PrP-peptides.

    abstract::To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289909015816

    authors: Takahashi H,Takahashi RH,Hasegawa H,Horiuchi M,Shinagawa M,Yokoyama T,Kimura K,Haritani M,Kurata T,Nagashima K

    更新日期:1999-06-01 00:00:00

  • Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein.

    abstract::Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transform...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490499524

    authors: Holmøy T,Kvale EØ,Vartdal F

    更新日期:2004-10-01 00:00:00

  • Neural dysregulation during a working memory task in human immunodeficiency virus-seropositive and hepatitis C coinfected individuals.

    abstract::Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0257-3

    authors: Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

    更新日期:2014-08-01 00:00:00

  • Viral protein R polymorphisms in the pathogenesis of HIV-associated acute ischaemic stroke: a case-control study.

    abstract::HIV-1 viral proteins have been implicated in endothelial dysfunction, which is a major determinant of ischaemic stroke risk in HIV-infected individuals. Polymorphisms in HIV-1 viral protein R (Vpr) may alter its potential to promote endothelial dysfunction, by modifying its effects on viral replication, reactivation o...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-020-00936-y

    authors: McMullen K,Bateman K,Stanley A,Combrinck M,Engelbrecht S,Bryer A

    更新日期:2021-01-18 00:00:00

  • Association of HIV serostatus and metabolic syndrome with neurobehavioral disturbances.

    abstract::Metabolic syndrome (MetS), a constellation of related metabolic risk factors, is a common comorbidity associated with cognitive difficulty in people living with HIV (PLWH). Neurobehavioral disturbances (e.g., behavioral manifestations of frontal-subcortical dysfunction) are also prevalent in HIV, yet the role MetS mig...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-020-00878-5

    authors: Pope CN,Montoya JL,Vasquez E,Pérez-Santiago J,Ellis R,McCutchan JA,Jeste DV,Moore DJ,Marquine MJ

    更新日期:2020-12-01 00:00:00

  • Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59.

    abstract::Murine hepatitis virus A59 infection of the central nervous system (CNS) results in CNS demyelination in susceptible strains of mice. In infected B-cell-deficient mice, demyelination not only occurred but was also more severe than in parental C57BL/6 animals. This increase may be due to the persistence of virus in the...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280290049697

    authors: Matthews AE,Lavi E,Weiss SR,Paterson Y

    更新日期:2002-06-01 00:00:00

  • Alzheimer's disease neuropathology may not predict functional impairment in HIV: a report of two individuals.

    abstract::With aging of HIV populations, there is concern that Alzheimer's disease (AD) may become prevalent and difficult to distinguish from HIV-associated neurocognitive disorders. To date, there are no reports documenting histologically verified Alzheimer's neuropathology in individuals with HIV and dementia. Herein, we rep...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-018-0663-z

    authors: Morgello S,Jacobs M,Murray J,Byrd D,Neibart E,Mintz L,Meloni G,Chon C,Crary J

    更新日期:2018-10-01 00:00:00

  • Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study.

    abstract::HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-012-0135-9

    authors: Zhu T,Zhong J,Hu R,Tivarus M,Ekholm S,Harezlak J,Ombao H,Navia B,Cohen R,Schifitto G

    更新日期:2013-02-01 00:00:00

  • Long-term virological effect of highly active antiretroviral therapy on cerebrospinal fluid and relationship with genotypic resistance.

    abstract::The objective of this study was to assess the long-term virological response in cerebrospinal fluid (CSF) in patients treated with highly active antiretroviral therapy (HAART) and to compare this response to CSF and plasma human immunodeficiency virus (HIV) drug resistance profiles. Paired CSF and plasma specimens wer...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/753312753

    authors: Bestetti A,Presi S,Pierotti C,Bossolasco S,Sala S,Racca S,Carrera P,Lazzarin A,Cinque P

    更新日期:2004-01-01 00:00:00

  • Central nervous system (CNS) enterovirus infections: A single center retrospective study on clinical features, diagnostic studies, and outcome.

    abstract::Enteroviruses (EV) are responsible for a large number of meningoencephalitis cases, especially in children. The objective of this study was to identify modes of diagnosis including the significance of respiratory and cerebrospinal fluid samples, associated clinical characteristics, inpatient management, and outcome of...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00784-5

    authors: Torres SD,Jia DT,Schorr EM,Park BL,Boubour A,Boehme A,Ankam JV,Gofshteyn JS,Tyshkov C,Green DA,Vargas W,Zucker J,Yeshokumar AK,Thakur KT

    更新日期:2020-02-01 00:00:00

  • Incidence of symptomatic CSF viral escape in HIV infected patients receiving atazanavir/ritonavir (ATV/r)-containing ART: a tertiary care cohort in western India.

    abstract::This single-center study attempts to quantify the incidence of symptomatic CSF viral escape (CSFVE) in patients receiving atazanavir/r (ATV/r)-containing regimen. We performed a retrospective analysis of patients receiving ATV/r-containing ART who were diagnosed with symptomatic CSFVE from August 2012 to January 2017....

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-018-0642-4

    authors: Patel AK,Patel KK,Gohel S,Kumar A,Letendre S

    更新日期:2018-08-01 00:00:00

  • Update on multiple sclerosis rehabilitation.

    abstract::The neuromotor rehabilitative treatment should be joined in the global individualised project. The rehabilitation project is developed by an interdisciplinary. Hence, the clinicians have to promote an appropriate compensation process in the daily living activities with a rapid insertion of new or recovered motor-postu...

    journal_title:Journal of neurovirology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Cardini RG,Crippa AC,Cattaneo D

    更新日期:2000-05-01 00:00:00

  • Human encephalitis caused by pseudorabies virus infection: a case report.

    abstract::Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of hu...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00822-2

    authors: Wang D,Tao X,Fei M,Chen J,Guo W,Li P,Wang J

    更新日期:2020-06-01 00:00:00

  • Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status.

    abstract::The combined effects of human immunodeficiency virus (HIV), obesity, and elevated visceral adipose tissue (VAT) on brain structure are unknown. In a cross-sectional analysis of Multicenter AIDS Cohort Study (MACS) participants, we determined associations between HIV serostatus, adiposity, and brain structure. Men (133...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-016-0507-7

    authors: Lake JE,Popov M,Post WS,Palella FJ,Sacktor N,Miller EN,Brown TT,Becker JT

    更新日期:2017-06-01 00:00:00

  • Decreased MEG beta oscillations in HIV-infected older adults during the resting state.

    abstract::The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-013-0220-8

    authors: Becker KM,Heinrichs-Graham E,Fox HS,Robertson KR,Sandkovsky U,O'Neill J,Swindells S,Wilson TW

    更新日期:2013-12-01 00:00:00

  • Genotypes of JC virus, DNA of cytomegalovirus, and proviral DNA of human immunodeficiency virus in eyes of acquired immunodeficiency syndrome patients.

    abstract::JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280590900391

    authors: Eberwein P,Hansen LL,Agostini HT

    更新日期:2005-02-01 00:00:00

  • Effort and neuropsychological performance in HIV-infected individuals on stable combination antiretroviral therapy.

    abstract::The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-017-0557-5

    authors: Paul R,Rhee G,Baker LM,Vaida F,Cooley SA,Ances BM

    更新日期:2017-10-01 00:00:00

  • Peripheral polyneuropathy associated with Chikungunya virus infection.

    abstract::The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-019-00782-7

    authors: Silva VP,Costa DS,Carvalho VCCVL,Garcês TCCS,Barros ELT,Oliveira JS,Pereira ACTC,Ferreira GP

    更新日期:2020-02-01 00:00:00

  • Prophylactic and therapeutic effects of human immunoglobulin on the pathobiology of HSV-1 infection, latency, and reactivation in mice.

    abstract::Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/135502802317247794

    authors: Dalai SK,Pesnicak L,Miller GF,Straus SE

    更新日期:2002-02-01 00:00:00

  • NTPDase and 5'-nucleotidase activities in synaptosomes of rabbits experimentally infected with BoHV-5.

    abstract::Bovine herpesvirus type 5 (BoHV-5) is the causative agent of herpetic meningoencephalitis in cattle. The purinergic system is described as a modulator of the immune response and neuroinflammation. These functions are related to the extracellular nucleotides concentration. NTPDase and 5'-nucleotidase are enzymes respon...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-015-0349-8

    authors: da Silva CB,Paim FC,Wolkmer P,Abdalla FH,Carvalho FB,Palma HH,Mello CB,Flores EF,Andrade CM,Lopes ST

    更新日期:2015-10-01 00:00:00

  • Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals.

    abstract::Human immunodeficiency virus (HIV) dementia remains as an important cause of neurological morbidity among HIV-seropositive (HIV+) individuals. Differences in the neuropsychological profiles between older and younger HIV+ individuals have not been examined extensively. The objective of this study was to examine the neu...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280701258423

    authors: Sacktor N,Skolasky R,Selnes OA,Watters M,Poff P,Shiramizu B,Shikuma C,Valcour V

    更新日期:2007-06-01 00:00:00

  • Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease.

    abstract::Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0293-z

    authors: Paul RH,Joska JA,Woods C,Seedat S,Engelbrecht S,Hoare J,Heaps J,Valcour V,Ances B,Baker LM,Salminen LE,Stein DJ

    更新日期:2014-12-01 00:00:00

  • Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associa

    abstract::HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1007/s13365-014-0279-x

    authors: Ndhlovu LC,Umaki T,Chew GM,Chow DC,Agsalda M,Kallianpur KJ,Paul R,Zhang G,Ho E,Hanks N,Nakamoto B,Shiramizu BT,Shikuma CM

    更新日期:2014-12-01 00:00:00

  • Correction to: Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event.

    abstract::The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...

    journal_title:Journal of neurovirology

    pub_type: 已发布勘误

    doi:10.1007/s13365-018-0637-1

    authors: Berger JR,Malik V,Lacey S,Brunetta P,Lehane PB

    更新日期:2018-06-01 00:00:00

  • The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection.

    abstract::When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280490261716

    authors: Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

    更新日期:2004-02-01 00:00:00

  • Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes.

    abstract::Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550289609146542

    authors: Sumner C,Shinohara T,Durham L,Traub R,Major EO,Amemiya K

    更新日期:1996-04-01 00:00:00

  • Safety and efficacy of interferon-alpha in 167 patients with human T-cell lymphotropic virus type 1-associated myelopathy.

    abstract::A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.1080/13550280701397627

    authors: Arimura K,Nakagawa M,Izumo S,Usuku K,Itoyama Y,Kira J,Osame M

    更新日期:2007-08-01 00:00:00

  • CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex.

    abstract::AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia ...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章

    doi:10.3109/13550280009091948

    authors: Bjugstad KB,Flitter WD,Garland WA,Philpot RM,Kirstein CL,Arendash GW

    更新日期:2000-12-01 00:00:00

  • Herpes simplex virus-1 and varicella-zoster virus latency in ganglia.

    abstract::Two human alpha-herpesviruses, herpes simplex virus (HSV)-1 and varicella zoster virus (VZV), account for the most frequent and serious neurologic disease caused by any of the eight human herpesviruses. Both HSV-1 and VZV become latent in ganglia. In this review, the authors describe features of latency for these viru...

    journal_title:Journal of neurovirology

    pub_type: 杂志文章,评审

    doi:10.1080/13550280390194000

    authors: Mitchell BM,Bloom DC,Cohrs RJ,Gilden DH,Kennedy PG

    更新日期:2003-04-01 00:00:00