Neurocytotoxity of quinolinic acid in human brain cultures.

abstract：:We report varicella-zoster virus (VZV) meningitis in a healthy adult woman with no antecedent rash and with hypoglycorrhachia. Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody. ...

journal_title：Journal of neurovirology

authors： Habib AA,Gilden D,Schmid DS,Safdieh JE

更新日期：2009-04-01 00:00:00

abstract：:Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the s...

journal_title：Journal of neurovirology

authors： Coughlin JM,Wang Y,Ma S,Yue C,Kim PK,Adams AV,Roosa HV,Gage KL,Stathis M,Rais R,Rojas C,McGlothan JL,Watkins CC,Sacktor N,Guilarte TR,Zhou Y,Sawa A,Slusher BS,Caffo B,Kassiou M,Endres CJ,Pomper MG

更新日期：2014-06-01 00:00:00

abstract：:Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine ...

journal_title：Journal of neurovirology

authors： Huang MB,Weeks O,Zhao LJ,Saltarelli M,Bond VC

更新日期：2000-06-01 00:00:00

abstract：:It is increasingly evident that the human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has a unique role in neuropathogenesis. Its ability to induce G2/M arrest coupled with its capacity to increase viral gene transcription gives it a unique role in sustaining viral replication and aiding in the establi...

journal_title：Journal of neurovirology

authors： James T,Nonnemacher MR,Wigdahl B,Krebs FC

更新日期：2016-08-01 00:00:00

abstract：:Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivati...

journal_title：Journal of neurovirology

authors： Del Borgo C,Belvisi V,Valli MB,Currà A,Pozzetto I,Sepe M,Mastroianni CM

更新日期：2017-08-01 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...

journal_title：Journal of neurovirology

authors： Nguyen TB,Lucero GR,Chana G,Hult BJ,Tatro ET,Masliah E,Grant I,Achim CL,Everall IP,HIV Neurobehavioral Research Group.

更新日期：2009-09-01 00:00:00

abstract：:Clinical or laboratory evidence of varicella-zoster virus (VZV) infection has been consistently associated with lower glioma risk in case-control studies, suggesting a protective effect of VZV against glioma. We formulated the following explanatory hypotheses: reactivated VZV preferentially infects and kills gliomas c...

journal_title：Journal of neurovirology

authors： Canniff J,Donson AM,Foreman NK,Weinberg A

更新日期：2011-10-01 00:00:00

abstract：:The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia...

journal_title：Journal of neurovirology

authors： Silva VP,Costa DS,Carvalho VCCVL,Garcês TCCS,Barros ELT,Oliveira JS,Pereira ACTC,Ferreira GP

更新日期：2020-02-01 00:00:00

abstract：:Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...

journal_title：Journal of neurovirology

authors： Oliver KR,Scallan MF,Dyson H,Fazakerley JK

更新日期：1997-02-01 00:00:00

abstract：:JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...

journal_title：Journal of neurovirology

authors： Pagani E,Delbue S,Mancuso R,Borghi E,Tarantini L,Ferrante P

更新日期：2003-10-01 00:00:00

abstract：:Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein-Bar...

journal_title：Journal of neurovirology

authors： Portolani M,Sabbatini AM,Meacci M,Pietrosemoli P,Cermelli C,Lunghi P,Golinelli F,Stacca R

更新日期：1998-08-01 00:00:00

abstract：:The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...

journal_title：Journal of neurovirology

authors： Mankowski JL,Queen SE,Kirstein LM,Spelman JP,Laterra J,Simpson IA,Adams RJ,Clements JE,Zink MC

更新日期：1999-12-01 00:00:00

abstract：:Natalizumab therapy in multiple sclerosis has been associated with JC polyomavirus-induced progressive multifocal leucoencephalopathy. We hypothesized that natalizumab may also lead to reactivation of BK, a related human polyomavirus capable of causing morbidity in immunosuppressed groups. Patients with relapsing remi...

journal_title：Journal of neurovirology

authors： Lonergan RM,Carr MJ,De Gascun CF,Costelloe LF,Waters A,Coughlan S,Duggan M,Doyle K,Jordan S,Hutchinson MW,Hall WW,Tubridy NJ

更新日期：2009-09-01 00:00:00

abstract：:Over the past decade there has been a revolution in the understanding and care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-associated disease. Much of this progress stems from a broader recognition of the importance of differences in viral types, including receptor preference(s), repl...

journal_title：Journal of neurovirology

authors： van Marle G,Power C

更新日期：2005-04-01 00:00:00

abstract：:Latent infection of sensory neurons and reactivation are necessary for maintenance of herpes simplex virus type 1 (HSV-1) in its host population. It has been proposed that the HSV-1 early gene, thymidine kinase (TK), may play an important regulatory role in this process. The authors used reporter transgenic mice to te...

journal_title：Journal of neurovirology

authors： Loiacono CM,Myers R,Mitchell WJ

更新日期：2004-04-01 00:00:00

abstract：:A significant number of human immunodeficiency virus type 1 (HIV-1)-infected patients are alcoholics. Either alcohol or HIV alone induces morphological and functional damage to the nervous system. HIV-1 Tat is a potent transcriptional activator of the viral promoter, with the ability to modulate a number of cellular r...

journal_title：Journal of neurovirology

authors： Brailoiu E,Brailoiu GC,Mameli G,Dolei A,Sawaya BE,Dun NJ

更新日期：2006-02-01 00:00:00

abstract：:The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...

journal_title：Journal of neurovirology

authors： Dos Santos DN,Sá KN,Queirós FC,Paixão AB,Santos KOB,de Andrade RCP,Camatti JR,Baptista AF

更新日期：2021-01-06 00:00:00

abstract：:Rapid maturation of major white matter pathways occurs in the first 2 years of life, indicating a critical neuronal developmental period. The impact of initiating antiretroviral therapy (ART) in children perinatally infected with HIV-1, after the age of 2 years on neurocognitive functioning and white matter developmen...

journal_title：Journal of neurovirology

authors： Hoare J,Heany SJ,Fouche JP,Phillips N,Joska JA,Myer L,Zar HJ,Stein DJ

更新日期：2019-04-01 00:00:00

abstract：:Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...

journal_title：Journal of neurovirology

authors： Williams R,Bokhari S,Silverstein P,Pinson D,Kumar A,Buch S

更新日期：2008-08-01 00:00:00

abstract：:We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospi...

journal_title：Journal of neurovirology

authors： Reddi A,Patel N,Morris NA

更新日期：2019-12-01 00:00:00

abstract：:The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant virus...

journal_title：Journal of neurovirology

authors： Morimoto K,Foley HD,McGettigan JP,Schnell MJ,Dietzschold B

更新日期：2000-10-01 00:00:00

abstract：:Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...

journal_title：Journal of neurovirology

authors： Du Pasquier RA,Clark KW,Smith PS,Joseph JT,Mazullo JM,De Girolami U,Letvin NL,Koralnik IJ

更新日期：2001-08-01 00:00:00

abstract：:Two human alpha-herpesviruses, herpes simplex virus (HSV)-1 and varicella zoster virus (VZV), account for the most frequent and serious neurologic disease caused by any of the eight human herpesviruses. Both HSV-1 and VZV become latent in ganglia. In this review, the authors describe features of latency for these viru...

journal_title：Journal of neurovirology

authors： Mitchell BM,Bloom DC,Cohrs RJ,Gilden DH,Kennedy PG

更新日期：2003-04-01 00:00:00

abstract：:The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...

journal_title：Journal of neurovirology

authors： Keegan MR,Winston A,Higgs C,Fuchs D,Boasso A,Nelson M

更新日期：2019-02-01 00:00:00

abstract：:Acute hemorrhagic leukoencephalitis (AHL) is a rare and usually fatal disorder characterized clinically by an acute onset of neurologic abnormalities. It may occur in association with a viral illness or vaccination. Radiology and brain biopsy are essential for the diagnosis. The etiology of AHL is unclear. We postulat...

journal_title：Journal of neurovirology

authors： An SF,Groves M,Martinian L,Kuo LT,Scaravilli F

更新日期：2002-10-01 00:00:00

abstract：:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...

journal_title：Journal of neurovirology

authors： Su YH,Zhang X,Aiamkitsumrit B,Tang Q,Maul G,Fraser NW,Block TM

更新日期：2006-10-01 00:00:00

abstract：:Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika...

journal_title：Journal of neurovirology

authors： Koppolu V,Shantha Raju T

更新日期：2018-06-01 00:00:00

abstract：:Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...

journal_title：Journal of neurovirology

authors： Sumner C,Shinohara T,Durham L,Traub R,Major EO,Amemiya K

更新日期：1996-04-01 00:00:00

abstract：:In the highly active antiretroviral therapy (HAART) era, the role of the inflammatory response in acquired immunodeficiency syndrome (AIDS)-related progressive multifocal leukoencephalopathy (PML) remains controversial. In this study, JC virus DNA load and levels of cytokines were determined in cerebrospinal fluid (CS...

journal_title：Journal of neurovirology

authors： Marzocchetti A,Cingolani A,Giambenedetto SD,Ammassari A,Giancola ML,Cauda R,Antinori A,Luca AD

更新日期：2005-04-01 00:00:00

abstract：:Infection of C57BL/6 mice with mouse hepatitis virus strain V5A13.1 (MHV-V5A13.1) results in an acute encephalitis followed by a chronic, progressive demyelinating disease with clinical and histological similarities to the human demyelinating disease Multiple Sclerosis (MS). Studies were undertaken to evaluate the con...

journal_title：Journal of neurovirology

authors： Lane TE,Fox HS,Buchmeier MJ

更新日期：1999-02-01 00:00:00