The herpes simplex virus type 1 early gene (thymidine kinase) promoter is activated in neurons of brain, but not trigeminal ganglia, of transgenic mice in the absence of viral proteins.

abstract：:Infection of C57BL/6 mice with mouse hepatitis virus strain V5A13.1 (MHV-V5A13.1) results in an acute encephalitis followed by a chronic, progressive demyelinating disease with clinical and histological similarities to the human demyelinating disease Multiple Sclerosis (MS). Studies were undertaken to evaluate the con...

journal_title：Journal of neurovirology

authors： Lane TE,Fox HS,Buchmeier MJ

更新日期：1999-02-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) has been implicated in neurological complications in developed countries. Developing countries have different viral clades and potentially different genetic and social risks for these complications. Baseline neurological performance measures associated with HIV infection have rarely ...

journal_title：Journal of neurovirology

authors： Clifford DB,Mitike MT,Mekonnen Y,Zhang J,Zenebe G,Melaku Z,Zewde A,Gessesse N,Wolday D,Messele T,Teshome M,Evans S

更新日期：2007-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dement...

journal_title：Journal of neurovirology

authors： Gray LR,Gabuzda D,Cowley D,Ellett A,Chiavaroli L,Wesselingh SL,Churchill MJ,Gorry PR

更新日期：2011-02-01 00:00:00

abstract：:We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and b...

journal_title：Journal of neurovirology

authors： Arslan F,Tabak F,Avşar E,Midilli K,Mert A,Ozaras R,Soysal T,Ozturk R,Ferhanoglu B

更新日期：2010-03-01 00:00:00

abstract：:Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...

journal_title：Journal of neurovirology

authors： Cysique LA,Dermody N,Carr A,Brew BJ,Teesson M

更新日期：2016-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the...

journal_title：Journal of neurovirology

authors： Cinque P,Cleator GM,Weber T,Monteyne P,Sindic C,Gerna G,van Loon AM,Klapper PE

更新日期：1998-02-01 00:00:00

abstract：:Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of hu...

journal_title：Journal of neurovirology

authors： Wang D,Tao X,Fei M,Chen J,Guo W,Li P,Wang J

更新日期：2020-06-01 00:00:00

abstract：:The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...

journal_title：Journal of neurovirology

authors： Keegan MR,Winston A,Higgs C,Fuchs D,Boasso A,Nelson M

更新日期：2019-02-01 00:00:00

abstract：:It is increasingly evident that the human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has a unique role in neuropathogenesis. Its ability to induce G2/M arrest coupled with its capacity to increase viral gene transcription gives it a unique role in sustaining viral replication and aiding in the establi...

journal_title：Journal of neurovirology

authors： James T,Nonnemacher MR,Wigdahl B,Krebs FC

更新日期：2016-08-01 00:00:00

abstract：:Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...

journal_title：Journal of neurovirology

authors： Oliver KR,Scallan MF,Dyson H,Fazakerley JK

更新日期：1997-02-01 00:00:00

abstract：:To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...

journal_title：Journal of neurovirology

authors： Takahashi H,Takahashi RH,Hasegawa H,Horiuchi M,Shinagawa M,Yokoyama T,Kimura K,Haritani M,Kurata T,Nagashima K

更新日期：1999-06-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macrophages. Lack of remyelination has been attributed to insufficient pro...

journal_title：Journal of neurovirology

authors： Benner B,Martorell AJ,Mahadevan P,Najm FJ,Tesar PJ,Freundt EC

更新日期：2016-06-01 00:00:00

abstract：:The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...

journal_title：Journal of neurovirology

authors： Cheeran MC,Gekker G,Hu S,Min X,Cox D,Lokensgard JR

更新日期：2004-06-01 00:00:00

abstract：:When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

journal_title：Journal of neurovirology

authors： Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2004-02-01 00:00:00

abstract：:Natalizumab therapy in multiple sclerosis has been associated with JC polyomavirus-induced progressive multifocal leucoencephalopathy. We hypothesized that natalizumab may also lead to reactivation of BK, a related human polyomavirus capable of causing morbidity in immunosuppressed groups. Patients with relapsing remi...

journal_title：Journal of neurovirology

authors： Lonergan RM,Carr MJ,De Gascun CF,Costelloe LF,Waters A,Coughlan S,Duggan M,Doyle K,Jordan S,Hutchinson MW,Hall WW,Tubridy NJ

更新日期：2009-09-01 00:00:00

abstract：:Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported t...

journal_title：Journal of neurovirology

authors： Poltermann S,Schlehofer B,Steindorf K,Schnitzler P,Geletneky K,Schlehofer JR

更新日期：2006-04-01 00:00:00

abstract：:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...

journal_title：Journal of neurovirology

authors： Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

更新日期：2016-04-01 00:00:00

abstract：:Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted inf...

journal_title：Journal of neurovirology

authors： Aronsson F,Lannebo C,Paucar M,Brask J,Kristensson K,Karlsson H

更新日期：2002-08-01 00:00:00

abstract：:Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of...

journal_title：Journal of neurovirology

authors： Hobbs JA

更新日期：2006-06-01 00:00:00

abstract：:After uniocular anterior chamber (AC) inoculation of herpes simplex virus type 1 (HSV-1), virus and TNF alpha (TNF-alpha) are detected in the suprachiasmatic nuclei (SCN). The goal of this study was to investigate the role of TNF-alpha and macrophages in the brain of HSV-1-infected BALB/c mice. Mice were treated with ...

journal_title：Journal of neurovirology

authors： Fields M,Zheng M,Zhang M,Atherton SS

更新日期：2006-12-01 00:00:00

abstract：:JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...

journal_title：Journal of neurovirology

authors： Pagani E,Delbue S,Mancuso R,Borghi E,Tarantini L,Ferrante P

更新日期：2003-10-01 00:00:00

abstract：:A significant number of human immunodeficiency virus type 1 (HIV-1)-infected patients are alcoholics. Either alcohol or HIV alone induces morphological and functional damage to the nervous system. HIV-1 Tat is a potent transcriptional activator of the viral promoter, with the ability to modulate a number of cellular r...

journal_title：Journal of neurovirology

authors： Brailoiu E,Brailoiu GC,Mameli G,Dolei A,Sawaya BE,Dun NJ

更新日期：2006-02-01 00:00:00

abstract：:In May 2012, the Division of AIDS Research at the National Institute of Mental Health (NIMH) organized the "Global NeuroAIDS Roundtable" in conjunction with the 11th International Symposium on Neurovirology and the 2012 Conference on HIV in the Nervous System. The meeting was held in New York, NY, USA and brought toge...

journal_title：Journal of neurovirology

authors： Joseph J,Achim CL,Boivin MJ,Brew BJ,Clifford DB,Colosi DA,Ellis RJ,Heaton RK,Gallo-Diop A,Grant I,Kanmogne GD,Kumar M,Letendre S,Marcotte TD,Nath A,Pardo CA,Paul RH,Pulliam L,Robertson K,Royal W 3rd,Sacktor N,Si

更新日期：2013-02-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...

journal_title：Journal of neurovirology

authors： Guan X,Liu J,Jiang H,Wu CX,Chen HC,Liu ZF

更新日期：2018-10-01 00:00:00

abstract：:Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure E...

journal_title：Journal of neurovirology

authors： Delle Donne V,Ciccarelli N,Massaroni V,Borghetti A,Dusina A,Farinacci D,Visconti E,Tamburrini E,Fabbiani M,Di Giambenedetto S

更新日期：2020-12-01 00:00:00

abstract：:A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...

journal_title：Journal of neurovirology

authors： Arimura K,Nakagawa M,Izumo S,Usuku K,Itoyama Y,Kira J,Osame M

更新日期：2007-08-01 00:00:00

abstract：:The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...

journal_title：Journal of neurovirology

authors： Mankowski JL,Queen SE,Kirstein LM,Spelman JP,Laterra J,Simpson IA,Adams RJ,Clements JE,Zink MC

更新日期：1999-12-01 00:00:00

abstract：:A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...

journal_title：Journal of neurovirology

authors： Sacktor NC,Skolasky RL,Lyles RH,Esposito D,Selnes OA,McArthur JC

更新日期：2000-02-01 00:00:00

abstract：:A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an R...

journal_title：Journal of neurovirology

authors： Azizi SA,Azizi SA

更新日期：2020-10-01 00:00:00

abstract：:Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...

journal_title：Journal of neurovirology

authors： Keltner JR,Fennema-Notestine C,Vaida F,Wang D,Franklin DR,Dworkin RH,Sanders C,McCutchan JA,Archibald SL,Miller DJ,Kesidis G,Cushman C,Kim SM,Abramson I,Taylor MJ,Theilmann RJ,Julaton MD,Notestine RJ,Corkran S,Chern

更新日期：2014-06-01 00:00:00