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The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection.

Abstract：

:When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3 cleavage during productive infection. Plasmids containing LAT or the LR gene inhibit caspase 3 activation in transiently transfected cells, suggesting productive infection blocks certain antiapoptotic properties of LAT. These studies demonstrate a correlation between the enhanced pathogenic potential of CJLAT and the LR gene inhibiting caspase 3 cleavage during productive infection.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

doi

10.1080/13550280490261716

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

64-70

issue

1

eissn

1355-0284

issn

1538-2443

pii

LBFPAUT255TKYPGX

journal_volume

10

pub_type

杂志文章

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