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Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy.

Abstract：

:Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted influenza A/WSN/33 strain in pregnant mice. Viral RNA and nucleoprotein were detected in fetal brains and the viral RNA persisted for at least 90 days of postnatal life. We have, thus, obtained evidence for transplacental passage of influenza virus in mice and the persistence of viral components in the brains of these animals into young adulthood.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Aronsson F,Lannebo C,Paucar M,Brask J,Kristensson K,Karlsson H

doi

10.1080/13550280290100480

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

353-7

issue

4

eissn

1355-0284

issn

1538-2443

journal_volume

8

pub_type

杂志文章

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