Abstract：
:Toscana virus (Bunyaviridae family, Phlebovirus genus) is a sandfly fever virus responsible for human neurological infections. Sandfly viruses are transmitted by insect vectors (Phlebotomus species) and the infection is present in climatic areas that allow the life cycle of the vector. The arthropode-borne Toscana virus is the etiologic agent of meningitis, meningoencephalitis, and encephalitis. The frequency of this neuropathic infection increases in the summer months, peaking in August in the endemic Mediterranean areas (Italy, Portugal, Spain, and Cyprus). Infection diagnosis is carried out by molecular assays and immunoenzymatic tests, which are rapid and sensitive. Recent studies have investigated the antigenic properties of the viral proteins (nucleoprotein N and surface glycoproteins G1 and G2), to better understand their immunogentic role.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Valassina M,Cusi MG,Valensin PEdoi
10.1080/13550280390247678subject
Has Abstractpub_date
2003-12-01 00:00:00pages
577-83issue
6eissn
1355-0284issn
1538-2443pii
CY06QDVAD9GXTQETjournal_volume
9pub_type
杂志文章,评审abstract：:There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00746-x
更新日期：2019-08-01 00:00:00
abstract：:The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...
journal_title：Journal of neurovirology
pub_type： 已发布勘误
doi：10.1007/s13365-018-0637-1
更新日期：2018-06-01 00:00:00
abstract：:Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0388-1
更新日期：2016-04-01 00:00:00
abstract：:It is increasingly evident that the human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has a unique role in neuropathogenesis. Its ability to induce G2/M arrest coupled with its capacity to increase viral gene transcription gives it a unique role in sustaining viral replication and aiding in the establi...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-016-0436-5
更新日期：2016-08-01 00:00:00
abstract：:In 2007, the nosology for HIV-1-associated neurocognitive disorders (HAND) was updated to a primarily neurocognitive disorder. However, currently available diagnostic tools lack the sensitivity and specificity needed for an accurate diagnosis for HAND. Scientists and clinicians, therefore, have been on a quest for an ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-018-0705-6
更新日期：2019-10-01 00:00:00
abstract：:The last 3 years have seen a dramatic fall in mortality and morbidity from HIV infection. Four factors have contributed to this: an improved understanding of the pathogenesis of HIV infection; the availability of tests that could measure plasma viral burden; the development of new and more powerful drugs such as the p...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...
journal_title：Journal of neurovirology
pub_type：
doi：10.1007/s13365-015-0322-6
更新日期：2015-06-01 00:00:00
abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the neurotropic human polyomavirus JC (JCV) lytic infection of oligodendrocytes. PML was first described as a complication of lymphoproliferative disorders more than 50 years ago and emerged as a major c...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-012-0080-7
更新日期：2012-02-01 00:00:00
abstract：:Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280601187177
更新日期：2007-04-01 00:00:00
abstract：:The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0361-z
更新日期：2015-10-01 00:00:00
abstract：:Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-014-0293-z
更新日期：2014-12-01 00:00:00
abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00838-z
更新日期：2020-06-01 00:00:00
abstract：:The entry of herpes simplex virus (HSV)-1 into cells is a complex process mediated in part by the binding of the HSV glycoprotein D (gD) to a specific cellular receptor identified as HveC, or nectin-1. We examined the distribution of HveC in sensory and motor neurons of the peripheral nervous system (PNS) by immunocyt...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/135502801753170336
更新日期：2001-10-01 00:00:00
abstract：:Over the past decade there has been a revolution in the understanding and care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-associated disease. Much of this progress stems from a broader recognition of the importance of differences in viral types, including receptor preference(s), repl...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280590922838
更新日期：2005-04-01 00:00:00
abstract：:A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly eleva...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00779-2
更新日期：2020-02-01 00:00:00
abstract：:There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory n...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-013-0179-5
更新日期：2013-08-20 00:00:00
abstract：:Nipah virus is a recently emergent paramyxovirus that is capable of causing severe disease in both humans and animals. The first outbreak of Nipah virus occurred in Malaysia and Singapore in 1999 and, more recently, outbreaks were detected in Bangladesh. In humans, Nipah virus causes febrile encephalitis with respirat...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280500187435
更新日期：2005-10-01 00:00:00
abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease affecting the central nervous system as a result of reactivation of the John Cunningham (JC) polyomavirus and occurs almost exclusively in immunosuppressed individuals. The disease course of PML is variable but usually progressive and often fa...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00899-0
更新日期：2020-12-01 00:00:00
abstract：:Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:In the highly active antiretroviral therapy (HAART) era, the role of the inflammatory response in acquired immunodeficiency syndrome (AIDS)-related progressive multifocal leukoencephalopathy (PML) remains controversial. In this study, JC virus DNA load and levels of cytokines were determined in cerebrospinal fluid (CS...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280590924539
更新日期：2005-04-01 00:00:00
abstract：:Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280903168131
更新日期：2009-09-01 00:00:00
abstract：:The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-013-0220-8
更新日期：2013-12-01 00:00:00
abstract：:Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009015823
更新日期：2000-06-01 00:00:00
abstract：:A method is described for amplification of the complete genome of the human polyomavirus JC (JCV) from progressive multifocal leukuencephalopathy (PML) brain, cerebrospinal fluid (CSF) of PML patients, and from the urine of controls without neurological disease. Efficient amplification with the 'long PCR' method is ac...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509114028
更新日期：1995-09-01 00:00:00
abstract：:The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant virus...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280009018301
更新日期：2000-10-01 00:00:00
abstract：:Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509111027
更新日期：1995-12-01 00:00:00
abstract：:Neurocognitive disorders such as dementia and cognitive/motor impairments are among the most significant complications associated with human immunodeficiency virus (HIV) infection, especially in aging populations, yet the pathogenesis remains poorly understood. Activated macrophages and microglia in white matter along...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-013-0229-z
更新日期：2014-02-01 00:00:00
abstract：:The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00730-5
更新日期：2019-06-01 00:00:00
abstract：:Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infe...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280802400684
更新日期：2009-01-01 00:00:00
abstract：:Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0386-3
更新日期：2016-04-01 00:00:00
