The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT).

abstract：:Neurodegeneration and human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are the major disease manifestations of HIV-1 colonization of the central nervous system (CNS). In the brain, HIV-1 replicates in microglial cells and infiltrating macrophages and it persists in a low-productive, noncytolytic s...

journal_title：Journal of neurovirology

authors： Su ZZ,Kang DC,Chen Y,Pekarskaya O,Chao W,Volsky DJ,Fisher PB

更新日期：2003-06-01 00:00:00

abstract：:Infection of C57BL/6 mice with mouse hepatitis virus strain V5A13.1 (MHV-V5A13.1) results in an acute encephalitis followed by a chronic, progressive demyelinating disease with clinical and histological similarities to the human demyelinating disease Multiple Sclerosis (MS). Studies were undertaken to evaluate the con...

journal_title：Journal of neurovirology

authors： Lane TE,Fox HS,Buchmeier MJ

更新日期：1999-02-01 00:00:00

abstract：:The latency-associated transcript (LAT) is the only herpes simplex virus type 1 (HSV-1) gene that is abundantly transcribed during latency. Plasmids expressing LAT inhibit apoptosis induced by etoposide and ceramide in transiently transfected cells. LAT also inhibits apoptosis in trigeminal ganglia of rabbits and prom...

journal_title：Journal of neurovirology

authors： Henderson G,Peng W,Jin L,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2002-12-01 00:00:00

abstract：:Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

journal_title：Journal of neurovirology

authors： Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

更新日期：1995-03-01 00:00:00

abstract：:Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the s...

journal_title：Journal of neurovirology

authors： Coughlin JM,Wang Y,Ma S,Yue C,Kim PK,Adams AV,Roosa HV,Gage KL,Stathis M,Rais R,Rojas C,McGlothan JL,Watkins CC,Sacktor N,Guilarte TR,Zhou Y,Sawa A,Slusher BS,Caffo B,Kassiou M,Endres CJ,Pomper MG

更新日期：2014-06-01 00:00:00

abstract：:An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...

journal_title：Journal of neurovirology

authors： Martins ML,de Freitas Carneiro-Proietti AB,Nicolato R,de Miranda DM,Romanelli LCF

更新日期：2018-08-01 00:00:00

abstract：:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...

journal_title：Journal of neurovirology

authors： Su YH,Zhang X,Aiamkitsumrit B,Tang Q,Maul G,Fraser NW,Block TM

更新日期：2006-10-01 00:00:00

abstract：:Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient c...

journal_title：Journal of neurovirology

authors： Paul RH,Phillips S,Hoare J,Laidlaw DH,Cabeen R,Olbricht GR,Su Y,Stein DJ,Engelbrecht S,Seedat S,Salminen LE,Baker LM,Heaps J,Joska J

更新日期：2017-04-01 00:00:00

abstract：:Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transform...

journal_title：Journal of neurovirology

authors： Holmøy T,Kvale EØ,Vartdal F

更新日期：2004-10-01 00:00:00

abstract：:A number of pathogenic microbes including neuroinvasive viruses, bacteria and parasites are capable of entry into the central nervous system (CNS) and cause a variety of clinical manifestations. The cellular and molecular mechanisms for the CNS invasion have been extensively studied in the last two decades. Viruses in...

journal_title：Journal of neurovirology

authors： Zhang JR,Tuomanen E

更新日期：1999-12-01 00:00:00

abstract：:Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported t...

journal_title：Journal of neurovirology

authors： Poltermann S,Schlehofer B,Steindorf K,Schnitzler P,Geletneky K,Schlehofer JR

更新日期：2006-04-01 00:00:00

abstract：:We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...

journal_title：Journal of neurovirology

authors： Budhram A,Liu Y,Krawczyk M,Chan TLH,Burneo JG,Hosseini-Moghaddam SM,Shoesmith C

更新日期：2019-06-01 00:00:00

abstract：:Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...

journal_title：Journal of neurovirology

authors： Armstrong NM,Surkan PJ,Treisman GJ,Sacktor NC,Irwin MR,Teplin LA,Stall R,Martin EM,Becker JT,Munro C,Levine AJ,Jacobson LP,Abraham AG

更新日期：2017-08-01 00:00:00

abstract：:Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV ...

journal_title：Journal of neurovirology

authors： Marcario JK,Manaye KF,SantaCruz KS,Mouton PR,Berman NE,Cheney PD

更新日期：2004-12-01 00:00:00

abstract：:In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...

journal_title：Journal of neurovirology

authors： Royal W 3rd,Cherner M,Carr J,Habib AG,Akomolafe A,Abimiku A,Charurat M,Farley J,Oluyemisi A,Mamadu I,Johnson J,Ellis R,McCutchan JA,Grant I,Blattner WA

更新日期：2012-06-01 00:00:00

abstract：:Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the...

journal_title：Journal of neurovirology

authors： Cinque P,Cleator GM,Weber T,Monteyne P,Sindic C,Gerna G,van Loon AM,Klapper PE

更新日期：1998-02-01 00:00:00

abstract：:Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly...

journal_title：Journal of neurovirology

authors： Oliveira BRSM,Vieira FV,de S Vieira D,da Silva SEL,Gameiro R,Flores EF,Cardoso TC

更新日期：2017-10-01 00:00:00

abstract：:Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...

journal_title：Journal of neurovirology

authors： Leyssen P,Paeshuyse J,Charlier N,Van Lommel A,Drosten C,De Clercq E,Neyts J

更新日期：2003-02-01 00:00:00

abstract：:Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

journal_title：Journal of neurovirology

authors： Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

更新日期：2014-08-01 00:00:00

abstract：:Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...

journal_title：Journal of neurovirology

authors： Dalai SK,Pesnicak L,Miller GF,Straus SE

更新日期：2002-02-01 00:00:00

abstract：:A neuroinvasive/neuropathogenic SIV variant termed SIVmac182 was previously isolated and characterized (Watry et al, 1994). This neuroinvasive strain was derived from the uncloned strain SIVmac251 through serial animal passage of infected microglia, unlike previously reported neurovirulent strains. Importantly, the vi...

journal_title：Journal of neurovirology

authors： Strelow LI,Watry DD,Fox HS,Nelson JA

更新日期：1998-06-01 00:00:00

abstract：:Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in people living with HIV. This effect was also observed in the central nervous system with the nowadays uncommon observation of dementias; yet in more recent works milder forms are still reported in 20-30% of optimally treated i...

journal_title：Journal of neurovirology

authors： De Benedetto I,Trunfio M,Guastamacchia G,Bonora S,Calcagno A

更新日期：2020-10-01 00:00:00

abstract：:Metabolic syndrome (MetS), a constellation of related metabolic risk factors, is a common comorbidity associated with cognitive difficulty in people living with HIV (PLWH). Neurobehavioral disturbances (e.g., behavioral manifestations of frontal-subcortical dysfunction) are also prevalent in HIV, yet the role MetS mig...

journal_title：Journal of neurovirology

authors： Pope CN,Montoya JL,Vasquez E,Pérez-Santiago J,Ellis R,McCutchan JA,Jeste DV,Moore DJ,Marquine MJ

更新日期：2020-12-01 00:00:00

abstract：:Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...

journal_title：Journal of neurovirology

authors： Bastianello S,Paolillo A,Giugni E,Giuliani S,Evangelisti G,Luccichenti G,Angeloni U,Colonnese C,Salvetti M,Gasperini C,Pozzilli C,Fieschi C

更新日期：2000-05-01 00:00:00

abstract：:Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...

journal_title：Journal of neurovirology

authors： Deb C,Howe CL

更新日期：2008-05-01 00:00:00

abstract：:HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...

journal_title：Journal of neurovirology

authors： Zhu T,Zhong J,Hu R,Tivarus M,Ekholm S,Harezlak J,Ombao H,Navia B,Cohen R,Schifitto G

更新日期：2013-02-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HANDs) continue to be common and are associated with increased morbidity and mortality. However, the underlying mechanisms in the combination antiretroviral therapy (cART) era are not fully understood. Interferon alpha (IFNα) is an antiviral cytokine found to be elevated in the...

journal_title：Journal of neurovirology

authors： Anderson AM,Lennox JL,Mulligan MM,Loring DW,Zetterberg H,Blennow K,Kessing C,Koneru R,Easley K,Tyor WR

更新日期：2017-02-01 00:00:00

abstract：:Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure E...

journal_title：Journal of neurovirology

authors： Delle Donne V,Ciccarelli N,Massaroni V,Borghetti A,Dusina A,Farinacci D,Visconti E,Tamburrini E,Fabbiani M,Di Giambenedetto S

更新日期：2020-12-01 00:00:00

abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...

journal_title：Journal of neurovirology

authors： Hentzien M,Guihot A,de Maindreville D,Tabary T,Brodard V,Vieillard V,Adle-Biassette H,Bani-Sadr F

更新日期：2020-08-01 00:00:00

abstract：:To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...

journal_title：Journal of neurovirology

authors： Takahashi H,Takahashi RH,Hasegawa H,Horiuchi M,Shinagawa M,Yokoyama T,Kimura K,Haritani M,Kurata T,Nagashima K

更新日期：1999-06-01 00:00:00