Abstract：
:There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory neurons capture and transport the virus to the spinal cord (SC) and then to the brain. It is probable that preferences for one pathway or another depend on the site of inoculation and the post-infection time. Therefore, in the present study, we evaluated different vertebral segments and post-infection times, along with the location, number, and subpopulation of sensory neurons susceptible to infection after inoculating RABV in the footpads of adult mice. It was noted that the virus inoculated in the footpad preferentially entered the CNS through the large-sized DRG sensory neurons, while infection of the motor neurons occurred later. Further, it was found that the virus was dispersed in spinal cord trans-synaptically through the interneurons, arriving at both sensory neurons and contralateral motor neurons. In conclusion, we observed that RABV inoculated in the plantar footpad is captured preferentially by large sensory neurons and is transported to the DRG, where it replicates and is spread to the SC using transynaptic jumps, infecting sensory and motor neurons at the same level before ascending to the brain.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Velandia-Romero ML,Castellanos JE,Martínez-Gutiérrez Mdoi
10.1007/s13365-013-0179-5subject
Has Abstractpub_date
2013-08-20 00:00:00eissn
1355-0284issn
1538-2443pub_type
杂志文章abstract：:Although highly active antiretroviral therapy (HAART) has reduced the incidence of dementia, a significant proportion of HIV-infected individuals cease therapy because of unacceptable side effects. Further, HAART is not available to the majority of HIV-infected people worldwide. Thus, animal models remain an important...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280290101076
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abstract：:Subacute sclerosing panencephalitis (SSPE) is a slowly progressive degenerative disorder caused by measles virus. It is characterised by typical clinical and electrophysiological features in the form of slow myoclonic jerks, with progressive cognitive impairment, visual symptoms, and periodic complexes on EEG, with ra...
journal_title：Journal of neurovirology
pub_type： 杂志文章
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abstract：:When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490261716
更新日期：2004-02-01 00:00:00
abstract：:In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280591002405
更新日期：2005-08-01 00:00:00
abstract：:Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390218751
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abstract：:Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-015-0368-5
更新日期：2016-02-01 00:00:00
abstract：:The recent ability to quantitate and localize the interaction of antigen-specific T cells in the central nervous system during infectious and autoimmune diseases will greatly enhance our understanding of the molecular and biologic basis of virus-induced diseases of the nervous and other systems. ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280490468438
更新日期：2004-08-01 00:00:00
abstract：:Maedi Visna Virus (MVV) is a prototypic lentivirus that causes infection only in cells of macrophage lineage, unlike the primate lentiviruses which infect both CD4+ T lymphocytes and macrophages. In primates, the earliest viral invasion is associated with the ability of the virus to infect and activate T cells which c...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809113480
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abstract：:A method is described for amplification of the complete genome of the human polyomavirus JC (JCV) from progressive multifocal leukuencephalopathy (PML) brain, cerebrospinal fluid (CSF) of PML patients, and from the urine of controls without neurological disease. Efficient amplification with the 'long PCR' method is ac...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509114028
更新日期：1995-09-01 00:00:00
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journal_title：Journal of neurovirology
pub_type： 杂志文章
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abstract：:It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma i...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0632-6
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abstract：:With aging of HIV populations, there is concern that Alzheimer's disease (AD) may become prevalent and difficult to distinguish from HIV-associated neurocognitive disorders. To date, there are no reports documenting histologically verified Alzheimer's neuropathology in individuals with HIV and dementia. Herein, we rep...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0663-z
更新日期：2018-10-01 00:00:00
abstract：:Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-013-0151-4
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journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0712-7
更新日期：2019-04-01 00:00:00
abstract：:A monocenter observational study was conducted to determine the clinical and virological effects of cidofovir added to highly active anti-retroviral therapy (HAART) in AIDS-associated progressive multifocal leukoencephalopathy (PML). Exposure to other anti-viral drugs or late initiation of cidofovir were exclusion cri...
journal_title：Journal of neurovirology
pub_type： 临床试验,杂志文章
doi：10.1080/13550280152537274
更新日期：2001-08-01 00:00:00
abstract：:JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280390241269
更新日期：2003-10-01 00:00:00
abstract：:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280600975358
更新日期：2006-10-01 00:00:00
abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...
journal_title：Journal of neurovirology
pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
abstract：:Chemokines and their receptors are constitutively present in the central nervous system (CNS), expressed in neurons and glial cells. Much evidence suggests that, beyond their involvement in neuroinflammation, these proteins play a role in neurodevelopment and neurophysiological signaling. The goal of this review is to...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280290100932
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abstract：:Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
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journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00822-2
更新日期：2020-06-01 00:00:00
abstract：:We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospi...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00760-z
更新日期：2019-12-01 00:00:00
abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00838-z
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abstract：:The combined effects of human immunodeficiency virus (HIV), obesity, and elevated visceral adipose tissue (VAT) on brain structure are unknown. In a cross-sectional analysis of Multicenter AIDS Cohort Study (MACS) participants, we determined associations between HIV serostatus, adiposity, and brain structure. Men (133...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-016-0507-7
更新日期：2017-06-01 00:00:00
abstract：:We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289609146898
更新日期：1996-10-01 00:00:00
abstract：:Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral inf...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909021998
更新日期：1999-04-01 00:00:00
abstract：:The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...
journal_title：Journal of neurovirology
pub_type： 已发布勘误
doi：10.1007/s13365-018-0637-1
更新日期：2018-06-01 00:00:00
abstract：:Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregates preferentially infected a microglia...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509113968
更新日期：1995-06-01 00:00:00
abstract：:To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909015816
更新日期：1999-06-01 00:00:00
