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HveC (nectin-1) is expressed at high levels in sensory neurons, but not in motor neurons, of the rat peripheral nervous system.

Abstract：

:The entry of herpes simplex virus (HSV)-1 into cells is a complex process mediated in part by the binding of the HSV glycoprotein D (gD) to a specific cellular receptor identified as HveC, or nectin-1. We examined the distribution of HveC in sensory and motor neurons of the peripheral nervous system (PNS) by immunocytochemistry. HveC is expressed at high levels in sensory neurons of dorsal root ganglion and their peripheral axons, at lower levels in motor neurons of spinal cord, and without detectable expression in motor nerve terminals at the neuromuscular junction. These results have implications regarding the tropism of HSV to specific neuronal populations, and for the construction of HSV-based vectors for the peripheral nervous system.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Mata M,Zhang M,Hu X,Fink DJ

doi

10.1080/135502801753170336

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

476-80

issue

5

eissn

1355-0284

issn

1538-2443

journal_volume

7

pub_type

杂志文章

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