Progressive multifocal leukoencephalopathy treated with nivolumab.

abstract：:Age-dependent poliomyelitis (ADPM) is a virally induced neuroparalytic disease of mice and a model for amyotrophic lateral sclerosis (ALS). ADPM is triggered in genetically susceptible mice by immunosuppression and infection with lactate dehydrogenase-elevating virus (LDV). Both ADPM and ALS are characterized by progr...

journal_title：Journal of neurovirology

authors： Schlenker EH,Jones QA,Rowland RR,Steffen-Bien M,Cafruny WA

更新日期：2001-06-01 00:00:00

abstract：:Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient c...

journal_title：Journal of neurovirology

authors： Paul RH,Phillips S,Hoare J,Laidlaw DH,Cabeen R,Olbricht GR,Su Y,Stein DJ,Engelbrecht S,Seedat S,Salminen LE,Baker LM,Heaps J,Joska J

更新日期：2017-04-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...

journal_title：Journal of neurovirology

authors： Takenouchi N,Tanaka M,Sato T,Yao J,Fujisawa JI,Izumo S,Kubota R,Matsuura E

更新日期：2020-06-01 00:00:00

abstract：:The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...

journal_title：Journal of neurovirology

authors： Canivet C,Uyar O,Rhéaume C,Piret J,Boivin G

更新日期：2019-06-01 00:00:00

abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...

journal_title：Journal of neurovirology

authors： Brew BJ,Robertson K,Wright EJ,Churchill M,Crowe SM,Cysique LA,Deeks S,Garcia JV,Gelman B,Gray LR,Johnson T,Joseph J,Margolis DM,Mankowski JL,Spencer B

更新日期：2015-06-01 00:00:00

abstract：:The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...

journal_title：Journal of neurovirology

authors： Berger JR,Malik V,Lacey S,Brunetta P,Lehane PB

更新日期：2018-06-01 00:00:00

abstract：:Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

journal_title：Journal of neurovirology

authors： Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

更新日期：2014-08-01 00:00:00

abstract：:Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transform...

journal_title：Journal of neurovirology

authors： Holmøy T,Kvale EØ,Vartdal F

更新日期：2004-10-01 00:00:00

abstract：:FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-...

journal_title：Journal of neurovirology

authors： Phillips TR,Prospero-Garcia O,Wheeler DW,Wagaman PC,Lerner DL,Fox HS,Whalen LR,Bloom FE,Elder JH,Henriksen SJ

更新日期：1996-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...

journal_title：Journal of neurovirology

authors： Kennedy PG,Cohrs RJ

更新日期：2010-11-01 00:00:00

abstract：:Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...

journal_title：Journal of neurovirology

authors： Williams R,Bokhari S,Silverstein P,Pinson D,Kumar A,Buch S

更新日期：2008-08-01 00:00:00

abstract：:Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...

journal_title：Journal of neurovirology

authors： Dalai SK,Pesnicak L,Miller GF,Straus SE

更新日期：2002-02-01 00:00:00

abstract：:A method is described for amplification of the complete genome of the human polyomavirus JC (JCV) from progressive multifocal leukuencephalopathy (PML) brain, cerebrospinal fluid (CSF) of PML patients, and from the urine of controls without neurological disease. Efficient amplification with the 'long PCR' method is ac...

journal_title：Journal of neurovirology

authors： Agostini HT,Stoner GL

更新日期：1995-09-01 00:00:00

abstract：:We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for oth...

journal_title：Journal of neurovirology

authors： Crossley KM,Agnihotri S,Chaganti J,Rodriguez ML,McNally LP,Venna N,Turbett SE,Gutman M,Morey A,Koralnik IJ,Brew BJ

更新日期：2016-08-01 00:00:00

abstract：:Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...

journal_title：Journal of neurovirology

authors： Tang Z,Dong E,Liu J,Liu Z,Wei W,Wang B,Li H,Tian J

更新日期：2016-04-01 00:00:00

abstract：:There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory n...

journal_title：Journal of neurovirology

authors： Velandia-Romero ML,Castellanos JE,Martínez-Gutiérrez M

更新日期：2013-08-20 00:00:00

abstract：:Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...

journal_title：Journal of neurovirology

authors： Rahimi P,Naser HM,Siadat SD,Sohrabi A,Mostafavi E,Motamedirad M,Bahramali G,Sadat SM,Ardestani MS

更新日期：2013-12-01 00:00:00

abstract：:The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...

journal_title：Journal of neurovirology

authors： Keegan MR,Winston A,Higgs C,Fuchs D,Boasso A,Nelson M

更新日期：2019-02-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the neurotropic human polyomavirus JC (JCV) lytic infection of oligodendrocytes. PML was first described as a complication of lymphoproliferative disorders more than 50 years ago and emerged as a major c...

journal_title：Journal of neurovirology

authors： Bellizzi A,Nardis C,Anzivino E,Rodìo D,Fioriti D,Mischitelli M,Chiarini F,Pietropaolo V

更新日期：2012-02-01 00:00:00

abstract：:Over the past decade there has been a revolution in the understanding and care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-associated disease. Much of this progress stems from a broader recognition of the importance of differences in viral types, including receptor preference(s), repl...

journal_title：Journal of neurovirology

authors： van Marle G,Power C

更新日期：2005-04-01 00:00:00

abstract：:Toscana virus (Bunyaviridae family, Phlebovirus genus) is a sandfly fever virus responsible for human neurological infections. Sandfly viruses are transmitted by insect vectors (Phlebotomus species) and the infection is present in climatic areas that allow the life cycle of the vector. The arthropode-borne Toscana vir...

journal_title：Journal of neurovirology

authors： Valassina M,Cusi MG,Valensin PE

更新日期：2003-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) associated central nervous system (CNS) infection is a rare disease. We report an atypical manifestation of EBV encephalitis initially presenting with a tumor-like lesion of the optic tract in an immunocompromised patient 8 years after a combined kidney and pancreas transplantation had been pe...

journal_title：Journal of neurovirology

authors： Khalil M,Enzinger C,Wallner-Blazek M,Scarpatetti M,Barth A,Horn S,Reiter G

更新日期：2008-11-01 00:00:00

abstract：:Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine ...

journal_title：Journal of neurovirology

authors： Huang MB,Weeks O,Zhao LJ,Saltarelli M,Bond VC

更新日期：2000-06-01 00:00:00

abstract：:Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted inf...

journal_title：Journal of neurovirology

authors： Aronsson F,Lannebo C,Paucar M,Brask J,Kristensson K,Karlsson H

更新日期：2002-08-01 00:00:00

abstract：:In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...

journal_title：Journal of neurovirology

authors： Ongrádi J,Rajda C,Maródi CL,Csiszár A,Vecsei L

更新日期：1999-10-01 00:00:00

abstract：:JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...

journal_title：Journal of neurovirology

authors： Eberwein P,Hansen LL,Agostini HT

更新日期：2005-02-01 00:00:00

abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...

journal_title：Journal of neurovirology

authors： Hentzien M,Guihot A,de Maindreville D,Tabary T,Brodard V,Vieillard V,Adle-Biassette H,Bani-Sadr F

更新日期：2020-08-01 00:00:00

abstract：:A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...

journal_title：Journal of neurovirology

authors： Sacktor NC,Skolasky RL,Lyles RH,Esposito D,Selnes OA,McArthur JC

更新日期：2000-02-01 00:00:00

abstract：:We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...

journal_title：Journal of neurovirology

authors： Gutierrez J,Murray J,Chon C,Morgello S

更新日期：2018-02-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...

journal_title：Journal of neurovirology

authors： Churchill MJ,Cowley DJ,Wesselingh SL,Gorry PR,Gray LR

更新日期：2015-06-01 00:00:00