Abstract:
:Coronavirus disease 2019 (COVID-19), first reported in Wuhan, the capital of Hubei, China, has been associated to a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In March 2020, the World Health Organization declared the SARS-CoV-2 infection a global pandemic. Soon after, the number of cases soared dramatically, spreading across China and worldwide. Italy has had 12,462 confirmed cases according to the Italian National Institute of Health (ISS) as of March 11, and after the "lockdown" of the entire territory, by May 4, 209,254 cases of COVID-19 and 26,892 associated deaths have been reported. We performed a review to describe, in particular, the origin and the diffusion of COVID-19 in Italy, underlying how the geographical circulation has been heterogeneous and the importance of pathophysiology in the involvement of cardiovascular and neurological clinical manifestations.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Prezioso C,Marcocci ME,Palamara AT,De Chiara G,Pietropaolo Vdoi
10.1007/s13365-020-00862-zsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
311-323issue
3eissn
1355-0284issn
1538-2443pii
10.1007/s13365-020-00862-zjournal_volume
26pub_type
杂志文章,评审abstract::Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infe...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802400684
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abstract::Rapid maturation of major white matter pathways occurs in the first 2 years of life, indicating a critical neuronal developmental period. The impact of initiating antiretroviral therapy (ART) in children perinatally infected with HIV-1, after the age of 2 years on neurocognitive functioning and white matter developmen...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0712-7
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abstract::The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible fo...
journal_title:Journal of neurovirology
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abstract::Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802105002
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abstract::JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590900391
更新日期:2005-02-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 已发布勘误
doi:10.1007/s13365-018-0637-1
更新日期:2018-06-01 00:00:00
abstract::Although highly active antiretroviral therapy (HAART) has reduced the incidence of dementia, a significant proportion of HIV-infected individuals cease therapy because of unacceptable side effects. Further, HAART is not available to the majority of HIV-infected people worldwide. Thus, animal models remain an important...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
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journal_title:Journal of neurovirology
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doi:10.1007/s13365-019-00785-4
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journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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abstract::AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280009091948
更新日期:2000-12-01 00:00:00
abstract::There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00746-x
更新日期:2019-08-01 00:00:00
abstract::Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...
journal_title:Journal of neurovirology
pub_type: 杂志文章
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journal_title:Journal of neurovirology
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abstract::HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0135-9
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pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00881-w
更新日期:2020-10-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
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abstract::The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...
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abstract::Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...
journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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abstract::Viral factors responsible for HSV neurovirulence in humans are still unknown. The aim of this work was to investigate the hypothesis that viral variants might contribute to the specific neurovirulence of some HSV strains. HSV-1 DNA was recovered from cerebrospinal fluid (CSF) in ten patients with HSV encephalitis (HSE...
journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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abstract::In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...
journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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