Abstract:
:Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice received a single 3.75 mg intraperitoneal injection of IgG 24 h before or 24 h, 48 h, or 72 h after ocular infection with 10(6) pfu of HSV-1 strain McKrae. Treatment with IgG protected against death in a time-dependent manner (P < 0.001 for -24 h vs. +48 h and +72 h IgG treatment groups). Viral shedding from the eyes was reduced more in mice treated with IgG at -24 h or +24 h relative to animals treated at +48 h. Viral titers in the eyes were reduced in mice treated with IgG at +24 h, but not at +48 h. In ganglia, virus recovery was reduced (P < 0.05) in mice treated at -24 h, +24 h, or +48 h relative to untreated mice, or ones treated at +72 h. In brains, similar results were observed in mice treated at -24 h, +24 h, or +48 h relative to +72 h. Upon explantation, virus reactivated from all ganglia of all surviving mice regardless of treatment group. DNA quantitation showed that mice pretreated with IgG tended towards lower quantities of latent genome copies compared to +24 h treatment and +48 h treatment. UV irradiation induced reactivation in vivo in 16/40 pretreated mice, 20/29 mice treated at +24 h, and in 8/8 mice treated at +48 h (P = 0.03 and P = 0.004, for comparisons at -24 h vs. +24 h, and -24 h vs. +48 h, respectively). Histopathological studies revealed that mice pretreated and treated with IgG had milder encephalitis and reduced virus spread compared to untreated mice. Pooled human IgG attenuates the spread of, and morbidity from, HSV-1 if given before and within 2 days after ocular infection.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Dalai SK,Pesnicak L,Miller GF,Straus SEdoi
10.1080/135502802317247794subject
Has Abstractpub_date
2002-02-01 00:00:00pages
35-44issue
1eissn
1355-0284issn
1538-2443journal_volume
8pub_type
杂志文章abstract::A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701397627
更新日期:2007-08-01 00:00:00
abstract::We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...
journal_title:Journal of neurovirology
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doi:10.1007/s13365-018-0717-2
更新日期:2019-06-01 00:00:00
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journal_title:Journal of neurovirology
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doi:10.1080/13550280701802543
更新日期:2008-01-01 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has be...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00838-z
更新日期:2020-06-01 00:00:00
abstract::There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...
journal_title:Journal of neurovirology
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abstract::Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280601187177
更新日期:2007-04-01 00:00:00
abstract::Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00843-2
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abstract::Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.3109/13550289809113490
更新日期:1998-02-01 00:00:00
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journal_title:Journal of neurovirology
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doi:10.1007/s13365-017-0534-z
更新日期:2017-08-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00822-2
更新日期:2020-06-01 00:00:00
abstract::Two human alpha-herpesviruses, herpes simplex virus (HSV)-1 and varicella zoster virus (VZV), account for the most frequent and serious neurologic disease caused by any of the eight human herpesviruses. Both HSV-1 and VZV become latent in ganglia. In this review, the authors describe features of latency for these viru...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280390194000
更新日期:2003-04-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280290101085
更新日期:2002-12-01 00:00:00
abstract::Acute hemorrhagic leukoencephalitis (AHL) is a rare and usually fatal disorder characterized clinically by an acute onset of neurologic abnormalities. It may occur in association with a viral illness or vaccination. Radiology and brain biopsy are essential for the diagnosis. The etiology of AHL is unclear. We postulat...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280260422749
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abstract::Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.3109/13550289609146880
更新日期:1996-06-01 00:00:00
abstract::The recent ability to quantitate and localize the interaction of antigen-specific T cells in the central nervous system during infectious and autoimmune diseases will greatly enhance our understanding of the molecular and biologic basis of virus-induced diseases of the nervous and other systems. ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280490468438
更新日期:2004-08-01 00:00:00
abstract::In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809114225
更新日期:1998-12-01 00:00:00
abstract::FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146904
更新日期:1996-12-01 00:00:00
abstract::HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0135-9
更新日期:2013-02-01 00:00:00
abstract::The most common complication of zoster in the elderly is postherpetic neuralgia, operationally defined as pain persisting longer than 1-2 months after rash. The cause of postherpetic neuralgia is unknown. Using polymerase chain reaction, we detected varicella zoster virus DNA in blood mononuclear cells from 11 of 51 p...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111018
更新日期:1995-03-01 00:00:00
abstract::We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146898
更新日期:1996-10-01 00:00:00
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journal_title:Journal of neurovirology
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doi:10.1080/13550280152403308
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abstract::Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290049534
更新日期:2002-04-01 00:00:00
abstract::Chemokines influence HIV neuropathogenesis by affecting the HIV life cycle, trafficking of macrophages into the nervous system, glial activation, and neuronal signaling and repair processes; however, knowledge of their relationship to in vivo measures of cerebral injury is limited. The primary objective of this study ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-010-0013-2
更新日期:2011-02-01 00:00:00
abstract::A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly eleva...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00779-2
更新日期:2020-02-01 00:00:00
abstract::Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0257-3
更新日期:2014-08-01 00:00:00
abstract::Infection of C57BL/6 mice with mouse hepatitis virus strain V5A13.1 (MHV-V5A13.1) results in an acute encephalitis followed by a chronic, progressive demyelinating disease with clinical and histological similarities to the human demyelinating disease Multiple Sclerosis (MS). Studies were undertaken to evaluate the con...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909029745
更新日期:1999-02-01 00:00:00
abstract::Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregates preferentially infected a microglia...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509113968
更新日期:1995-06-01 00:00:00
abstract::The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289709015807
更新日期:1997-04-01 00:00:00
abstract::We report varicella-zoster virus (VZV) meningitis in a healthy adult woman with no antecedent rash and with hypoglycorrhachia. Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody. ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280902725550
更新日期:2009-04-01 00:00:00
abstract::Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0368-5
更新日期:2016-02-01 00:00:00