Contrasting roles for Valpha14+ natural killer T cells in a viral model for multiple sclerosis.

Abstract:

:Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infection delayed the onset of demyelinating disease with higher interleukin-4 production, whereas administration during the late stage or weekly resulted in more severe demyelination with enhanced virus persistence. The effect of in vivo depletion of NKT cells differed depending on the stage of infection, suggesting contrasting roles for NKT cells over the disease course.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Tsunoda I,Tanaka T,Taniguchi M,Fujinami RS

doi

10.1080/13550280802400684

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

90-8

issue

1

eissn

1355-0284

issn

1538-2443

pii

907245142

journal_volume

15

pub_type

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