Abstract:
:Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infection delayed the onset of demyelinating disease with higher interleukin-4 production, whereas administration during the late stage or weekly resulted in more severe demyelination with enhanced virus persistence. The effect of in vivo depletion of NKT cells differed depending on the stage of infection, suggesting contrasting roles for NKT cells over the disease course.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Tsunoda I,Tanaka T,Taniguchi M,Fujinami RSdoi
10.1080/13550280802400684subject
Has Abstractpub_date
2009-01-01 00:00:00pages
90-8issue
1eissn
1355-0284issn
1538-2443pii
907245142journal_volume
15pub_type
杂志文章abstract::HIV viral proteins within the central nervous system are associated with the development of neurocognitive impairments in HIV-infected individuals. Dopamine transporter (DAT)-mediated dopamine transport is critical for normal dopamine homeostasis. Abnormal dopaminergic transmission has been implicated as a risk determ...
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