Abstract:
:Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported to be present in all of 27 glioma samples investigated in contrast to other brain tissues, and it was hypothesized that HCMV might play a role in glioma pathogenesis. To evaluate these findings, samples of 40 gliomas, 31 meningiomas, and 6 acoustic neurinomas (ACNs) were analyzed for the presence of HCMV macromolecules using polymerase chain reaction (PCR) and immunohistochemistry. Additionally, corresponding blood samples from 72 patients were analyzed for the presence of HCMV DNA to check for a possible contamination of tumor tissues with HCMV-infected blood cells. No HCMV DNA sequences were found, neither in brain tumor tissues nor in corresponding blood samples. Immunohistochemistry did not detect HCMV-specific proteins. Addressing a possible role of other herpesviruses as has been suggested in seroepidemiological studies, seroprevalence of antibodies to HCMV, herpes simplex virus (HSV), Epstein-Barr virus (EBV), and varicella-zoster virus (VZV) were determined by enzyme-linked immunosorbent assay (ELISA). Serological analyses of brain tumor patients showed no significant differences in the prevalences of antibodies to HCMV, HSV, EBV, or VZV compared to the general population. Thus, the data of the present study do not support the hypothesis of an association of herpesviruses with the development of primary brain tumors.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Poltermann S,Schlehofer B,Steindorf K,Schnitzler P,Geletneky K,Schlehofer JRdoi
10.1080/13550280600654573subject
Has Abstractpub_date
2006-04-01 00:00:00pages
90-9issue
2eissn
1355-0284issn
1538-2443pii
H1282N68873407MHjournal_volume
12pub_type
杂志文章abstract::Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280802074539
更新日期:2008-08-01 00:00:00
abstract::Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0386-3
更新日期:2016-04-01 00:00:00
abstract::The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...
journal_title:Journal of neurovirology
pub_type: 已发布勘误
doi:10.1007/s13365-018-0637-1
更新日期:2018-06-01 00:00:00
abstract::In May 2012, the Division of AIDS Research at the National Institute of Mental Health (NIMH) organized the "Global NeuroAIDS Roundtable" in conjunction with the 11th International Symposium on Neurovirology and the 2012 Conference on HIV in the Nervous System. The meeting was held in New York, NY, USA and brought toge...
journal_title:Journal of neurovirology
pub_type:
doi:10.1007/s13365-012-0143-9
更新日期:2013-02-01 00:00:00
abstract::An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0632-6
更新日期:2018-08-01 00:00:00
abstract::Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280903168131
更新日期:2009-09-01 00:00:00
abstract::A method is described for amplification of the complete genome of the human polyomavirus JC (JCV) from progressive multifocal leukuencephalopathy (PML) brain, cerebrospinal fluid (CSF) of PML patients, and from the urine of controls without neurological disease. Efficient amplification with the 'long PCR' method is ac...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509114028
更新日期:1995-09-01 00:00:00
abstract::HIV viral proteins within the central nervous system are associated with the development of neurocognitive impairments in HIV-infected individuals. Dopamine transporter (DAT)-mediated dopamine transport is critical for normal dopamine homeostasis. Abnormal dopaminergic transmission has been implicated as a risk determ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0391-6
更新日期:2016-06-01 00:00:00
abstract::Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/135502802317247794
更新日期:2002-02-01 00:00:00
abstract::The neuromotor rehabilitative treatment should be joined in the global individualised project. The rehabilitation project is developed by an interdisciplinary. Hence, the clinicians have to promote an appropriate compensation process in the daily living activities with a rapid insertion of new or recovered motor-postu...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-05-01 00:00:00
abstract::HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0279-x
更新日期:2014-12-01 00:00:00
abstract::Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-017-0564-6
更新日期:2017-10-01 00:00:00
abstract::It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma i...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280152537175
更新日期:2001-08-01 00:00:00
abstract::Rapid maturation of major white matter pathways occurs in the first 2 years of life, indicating a critical neuronal developmental period. The impact of initiating antiretroviral therapy (ART) in children perinatally infected with HIV-1, after the age of 2 years on neurocognitive functioning and white matter developmen...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-018-0712-7
更新日期:2019-04-01 00:00:00
abstract::Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of hu...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00822-2
更新日期:2020-06-01 00:00:00
abstract::Despite common clinical features to suggest encephalitis, different viral encephalitides are known to have some specific clinical features, which if present, may suggest infection by a particular virus. West Nile viral (WNV) encephalitis has not been described with any specific diagnostic feature so far. In this conte...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00733-2
更新日期:2019-06-01 00:00:00
abstract::Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part o...
journal_title:Journal of neurovirology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13365-015-0352-0
更新日期:2015-10-01 00:00:00
abstract::Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macrophages. Lack of remyelination has been attributed to insufficient pro...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0402-7
更新日期:2016-06-01 00:00:00
abstract::Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280390173319
更新日期:2003-02-01 00:00:00
abstract::On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...
journal_title:Journal of neurovirology
pub_type:
doi:10.1007/s13365-015-0322-6
更新日期:2015-06-01 00:00:00
abstract::The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-017-0557-5
更新日期:2017-10-01 00:00:00
abstract::To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590953825
更新日期:2005-07-01 00:00:00
abstract::HIV-associated neurocognitive disorders (HANDs) continue to be common and are associated with increased morbidity and mortality. However, the underlying mechanisms in the combination antiretroviral therapy (cART) era are not fully understood. Interferon alpha (IFNα) is an antiviral cytokine found to be elevated in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-016-0466-z
更新日期:2017-02-01 00:00:00
abstract::Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146542
更新日期:1996-04-01 00:00:00
abstract::Neurocognitive disorders such as dementia and cognitive/motor impairments are among the most significant complications associated with human immunodeficiency virus (HIV) infection, especially in aging populations, yet the pathogenesis remains poorly understood. Activated macrophages and microglia in white matter along...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0229-z
更新日期:2014-02-01 00:00:00
abstract::HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0135-9
更新日期:2013-02-01 00:00:00
abstract::A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701397627
更新日期:2007-08-01 00:00:00
abstract::A number of pathogenic microbes including neuroinvasive viruses, bacteria and parasites are capable of entry into the central nervous system (CNS) and cause a variety of clinical manifestations. The cellular and molecular mechanisms for the CNS invasion have been extensively studied in the last two decades. Viruses in...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909021288
更新日期:1999-12-01 00:00:00
abstract::When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490261716
更新日期:2004-02-01 00:00:00