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The stability of herpes simplex virus type I genomes in infected Vero cells undergoing viral induced apoptosis.

Abstract：

:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results show that, in the absence of DNA replication, the input genomes of wild-type (KOS), and replication compromised ICP27 deleted (d27-1) virus are remarkably stable. Intracellular half-lives of their genomes exceeded 24 hours. In contrast, the half-life of replication incompetent ICP4 deleted (d120) viral genomes were significantly less (approximately 8 hours). Interestingly, it was also noted that in cells infected under conditions permissible for replication, viral DNA replication occurs, even in cells undergoing apoptosis. The possibility that the genome structure and replication compartment formation provide protection to the HSV-1 genome from degradation is discussed.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Su YH,Zhang X,Aiamkitsumrit B,Tang Q,Maul G,Fraser NW,Block TM

doi

10.1080/13550280600975358

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

375-86

issue

5

eissn

1355-0284

issn

1538-2443

pii

Q53177Q2781796H0

journal_volume

12

pub_type

杂志文章

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