CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex.

abstract：:There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory n...

journal_title：Journal of neurovirology

authors： Velandia-Romero ML,Castellanos JE,Martínez-Gutiérrez M

更新日期：2013-08-20 00:00:00

abstract：:To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...

journal_title：Journal of neurovirology

authors： Takahashi H,Takahashi RH,Hasegawa H,Horiuchi M,Shinagawa M,Yokoyama T,Kimura K,Haritani M,Kurata T,Nagashima K

更新日期：1999-06-01 00:00:00

abstract：:Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...

journal_title：Journal of neurovirology

authors： Radbill AE,Reddy AT,Markert JM,Wyss JM,Pike MM,Akella NS,Bharara N,Gillespie GY

更新日期：2007-04-01 00:00:00

abstract：:A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...

journal_title：Journal of neurovirology

authors： Sacktor NC,Skolasky RL,Lyles RH,Esposito D,Selnes OA,McArthur JC

更新日期：2000-02-01 00:00:00

abstract：:We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...

journal_title：Journal of neurovirology

authors： Coscoy L,Gonzalez-Dunia D,Chirinian-Swan S,Brahic M,Ozden S

更新日期：1996-10-01 00:00:00

abstract：:In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...

journal_title：Journal of neurovirology

authors： Kent JR,Fraser NW

更新日期：2005-08-01 00:00:00

abstract：:Acute hemorrhagic leukoencephalitis (AHL) is a rare and usually fatal disorder characterized clinically by an acute onset of neurologic abnormalities. It may occur in association with a viral illness or vaccination. Radiology and brain biopsy are essential for the diagnosis. The etiology of AHL is unclear. We postulat...

journal_title：Journal of neurovirology

authors： An SF,Groves M,Martinian L,Kuo LT,Scaravilli F

更新日期：2002-10-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...

journal_title：Journal of neurovirology

authors： Ndhlovu LC,Umaki T,Chew GM,Chow DC,Agsalda M,Kallianpur KJ,Paul R,Zhang G,Ho E,Hanks N,Nakamoto B,Shiramizu BT,Shikuma CM

更新日期：2014-12-01 00:00:00

abstract：:Neurocognitive impairment (NCI) among HIV-infected patients is heterogeneous in its reported presentations and frequencies. To determine the prevalence of NCI and its associated subtypes as well as predictive variables, we investigated patients with HIV/AIDS receiving universal health care. Recruited adult HIV-infecte...

journal_title：Journal of neurovirology

authors： Tu W,Chen PA,Koenig N,Gomez D,Fujiwara E,Gill MJ,Kong L,Power C

更新日期：2020-02-01 00:00:00

abstract：:With aging of HIV populations, there is concern that Alzheimer's disease (AD) may become prevalent and difficult to distinguish from HIV-associated neurocognitive disorders. To date, there are no reports documenting histologically verified Alzheimer's neuropathology in individuals with HIV and dementia. Herein, we rep...

journal_title：Journal of neurovirology

authors： Morgello S,Jacobs M,Murray J,Byrd D,Neibart E,Mintz L,Meloni G,Chon C,Crary J

更新日期：2018-10-01 00:00:00

abstract：:With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of...

journal_title：Journal of neurovirology

authors： Mondal R,Ganguly U,Deb S,Shome G,Pramanik S,Bandyopadhyay D,Lahiri D

更新日期：2020-12-26 00:00:00

abstract：:A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly eleva...

journal_title：Journal of neurovirology

authors： Singhal T,Solomon I,Akbik F,Smirnakis S,Vaitkevicius H

更新日期：2020-02-01 00:00:00

abstract：:A pandemic due to novel coronavirus arose in mid-December 2019 in Wuhan, China, and in 3 months' time swept the world. The disease has been referred to as COVID-19, and the causative agent has been labelled SARS-CoV-2 due to its genetic similarities to the virus (SARS-CoV-1) responsible for the severe acute respirator...

journal_title：Journal of neurovirology

authors： Berger JR

更新日期：2020-04-01 00:00:00

abstract：:FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-...

journal_title：Journal of neurovirology

authors： Phillips TR,Prospero-Garcia O,Wheeler DW,Wagaman PC,Lerner DL,Fox HS,Whalen LR,Bloom FE,Elder JH,Henriksen SJ

更新日期：1996-12-01 00:00:00

abstract：:A number of pathogenic microbes including neuroinvasive viruses, bacteria and parasites are capable of entry into the central nervous system (CNS) and cause a variety of clinical manifestations. The cellular and molecular mechanisms for the CNS invasion have been extensively studied in the last two decades. Viruses in...

journal_title：Journal of neurovirology

authors： Zhang JR,Tuomanen E

更新日期：1999-12-01 00:00:00

abstract：:Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

journal_title：Journal of neurovirology

authors： Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

更新日期：1995-03-01 00:00:00

abstract：:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...

journal_title：Journal of neurovirology

authors： Su YH,Zhang X,Aiamkitsumrit B,Tang Q,Maul G,Fraser NW,Block TM

更新日期：2006-10-01 00:00:00

abstract：:Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient c...

journal_title：Journal of neurovirology

authors： Paul RH,Phillips S,Hoare J,Laidlaw DH,Cabeen R,Olbricht GR,Su Y,Stein DJ,Engelbrecht S,Seedat S,Salminen LE,Baker LM,Heaps J,Joska J

更新日期：2017-04-01 00:00:00

abstract：:Recent studies on the coreceptor usage of human immunodeficiency virus (HIV) strains associated with acquired immunodeficiency syndrome (AIDS) dementia have shown that both X4 and R5 viruses are involved in the process. The disease is associated with enhanced virus replication and monocyte chemoattractant protein (MCP...

journal_title：Journal of neurovirology

authors： Buch S,Sui Y,Potula R,Pinson D,Adany I,Li Z,Huang M,Li S,Dhillon N,Major E,Narayan O

更新日期：2004-01-01 00:00:00

abstract：:Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...

journal_title：Journal of neurovirology

authors： Williams R,Bokhari S,Silverstein P,Pinson D,Kumar A,Buch S

更新日期：2008-08-01 00:00:00

abstract：:Natalizumab therapy in multiple sclerosis has been associated with JC polyomavirus-induced progressive multifocal leucoencephalopathy. We hypothesized that natalizumab may also lead to reactivation of BK, a related human polyomavirus capable of causing morbidity in immunosuppressed groups. Patients with relapsing remi...

journal_title：Journal of neurovirology

authors： Lonergan RM,Carr MJ,De Gascun CF,Costelloe LF,Waters A,Coughlan S,Duggan M,Doyle K,Jordan S,Hutchinson MW,Hall WW,Tubridy NJ

更新日期：2009-09-01 00:00:00

abstract：:Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported t...

journal_title：Journal of neurovirology

authors： Poltermann S,Schlehofer B,Steindorf K,Schnitzler P,Geletneky K,Schlehofer JR

更新日期：2006-04-01 00:00:00

abstract：:Our previous studies in an experimental model of rabies showed neuronal process degeneration in association with severe clinical disease. Cultured adult rodent dorsal root ganglion neurons infected with challenge virus standard (CVS)-11 strain of rabies virus (RABV) showed axonal swellings and reduced axonal growth wi...

journal_title：Journal of neurovirology

authors： Kammouni W,Wood H,Saleh A,Appolinario CM,Fernyhough P,Jackson AC

更新日期：2015-08-01 00:00:00

abstract：:Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...

journal_title：Journal of neurovirology

authors： Chalermchai T,Valcour V,Sithinamsuwan P,Pinyakorn S,Clifford D,Paul RH,Tipsuk S,Fletcher JL,Degruttola V,Ratto-Kim S,Hutchings N,Shikuma C,Ananworanich J,SEARCH 007 and 011 study groups.

更新日期：2013-04-01 00:00:00

abstract：:Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine ...

journal_title：Journal of neurovirology

authors： Huang MB,Weeks O,Zhao LJ,Saltarelli M,Bond VC

更新日期：2000-06-01 00:00:00

abstract：:Bovine herpesvirus type 5 (BoHV-5) is the causative agent of herpetic meningoencephalitis in cattle. The purinergic system is described as a modulator of the immune response and neuroinflammation. These functions are related to the extracellular nucleotides concentration. NTPDase and 5'-nucleotidase are enzymes respon...

journal_title：Journal of neurovirology

authors： da Silva CB,Paim FC,Wolkmer P,Abdalla FH,Carvalho FB,Palma HH,Mello CB,Flores EF,Andrade CM,Lopes ST

更新日期：2015-10-01 00:00:00

abstract：:Retroviral infection can induce transcriptional activation of genes flanking the sites of proviral integration in target cells. Because integration is essentially random, this phenomenon can be exploited for random mutagenesis of the genome, and analysis of integration sites in tumors may identify potential oncogenes....

journal_title：Journal of neurovirology

authors： Afanasieva TA,Pekarik V,Grazia D'Angelo M,Klein MA,Voigtländer T,Stocking C,Aguzzi A

更新日期：2001-04-01 00:00:00

abstract：:In 2007, the nosology for HIV-1-associated neurocognitive disorders (HAND) was updated to a primarily neurocognitive disorder. However, currently available diagnostic tools lack the sensitivity and specificity needed for an accurate diagnosis for HAND. Scientists and clinicians, therefore, have been on a quest for an ...

journal_title：Journal of neurovirology

authors： McLaurin KA,Booze RM,Mactutus CF

更新日期：2019-10-01 00:00:00

abstract：:Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...

journal_title：Journal of neurovirology

authors： Leyssen P,Paeshuyse J,Charlier N,Van Lommel A,Drosten C,De Clercq E,Neyts J

更新日期：2003-02-01 00:00:00

abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...

journal_title：Journal of neurovirology

authors： Hentzien M,Guihot A,de Maindreville D,Tabary T,Brodard V,Vieillard V,Adle-Biassette H,Bani-Sadr F

更新日期：2020-08-01 00:00:00