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A pilot study on the antibodies to HHV-6 variants and HHV-7 in CSF of MS patients.

Abstract：

:In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with MS or other neurological disorders by ELISA. Predominance in the positivity of IgG (67%) and IgM (44%) to HHV-6B over that of IgG (44%) with no detectable IgM to HHV-6A, and no antibodies to HHV-7 were found in the CSF of MS patients. None of these antibodies were found in the CSF of controls. This suggests that, intrathecal chronic active or primary HHV-6B infection might contribute to MS progression, while the local effects of HHV-6A and HHV-7 seem to be less important.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Ongrádi J,Rajda C,Maródi CL,Csiszár A,Vecsei L

doi

10.3109/13550289909045382

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

529-32

issue

5

eissn

1355-0284

issn

1538-2443

journal_volume

5

pub_type

杂志文章

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