Abstract：
:Maedi Visna Virus (MVV) is a prototypic lentivirus that causes infection only in cells of macrophage lineage, unlike the primate lentiviruses which infect both CD4+ T lymphocytes and macrophages. In primates, the earliest viral invasion is associated with the ability of the virus to infect and activate T cells which convey virus to the brain. Infected monocytes in blood rarely cause CNS infection in absence of activation of CD4+ T cells. In the face of lack of infection or activation of T cells by MVV in sheep, the question arises, how does MVV gain access to the brain to cause the classical lesions of visna? In previous studies on experimental induction of visna, sheep were inoculated with virus directly in the brain. In this study, we asked whether neuroinvasion by MVV would occur if sheep were inoculated with virus in a non-neural site. Nine sheep were inoculated intratracheally and all developed systemic infection when examined 3 weeks later. At this time, five were injected intramuscularly with brain white matter homogenized in Freund's complete adjuvant to induce EAE. None of the four animals inoculated with virus alone developed CNS infection despite typical lentiviral infection in lungs, lymphoid tissues and blood-borne mononuclear cells. In contrast, all five of the sheep injected with brain homogenate developed infection in the brain. Virus was produced by macrophages associated with the EAE lesions. This study illustrated that both activated T cells specific for antigen in the CNS and infected macrophages are essential for lentivirus neuropathogenesis.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Chebloune Y,Karr BM,Raghavan R,Singh DK,Leung K,Sheffer D,Pinson D,Foresman L,Narayan Odoi
10.3109/13550289809113480subject
Has Abstractpub_date
1998-02-01 00:00:00pages
38-48issue
1eissn
1355-0284issn
1538-2443journal_volume
4pub_type
杂志文章abstract：:To verify the possibility of different role of JC virus genotypes in the etiology of progressive multifocal leukoencephalopathy, we analysed several JC virus isolates amplified from AIDS patients with and without progressive multifocal leukoencephalopathy and healthy controls by nucleotide sequencing. Cerebrospinal fl...
journal_title：Journal of neurovirology
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journal_title：Journal of neurovirology
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journal_title：Journal of neurovirology
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更新日期：2014-02-01 00:00:00
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journal_title：Journal of neurovirology
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：Journal of neurovirology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of neurovirology
pub_type： 杂志文章
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journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
doi：10.1007/s13365-014-0271-5
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journal_title：Journal of neurovirology
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journal_title：Journal of neurovirology
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journal_title：Journal of neurovirology
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journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289809113497
更新日期：1998-10-01 00:00:00
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journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289909015816
更新日期：1999-06-01 00:00:00
abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...
journal_title：Journal of neurovirology
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journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of neurovirology
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
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journal_title：Journal of neurovirology
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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