Abstract:
:Viral factors responsible for HSV neurovirulence in humans are still unknown. The aim of this work was to investigate the hypothesis that viral variants might contribute to the specific neurovirulence of some HSV strains. HSV-1 DNA was recovered from cerebrospinal fluid (CSF) in ten patients with HSV encephalitis (HSE) and the regions of HSV-1 gD gene corresponding to known antigenic sites were analyzed by direct sequencing of PCR products. Twenty-two mutations were found among a total of 6580 bp analyzed over a portion of 1000 bp of gD gene, of which 20 were silent whereas two conferred amino acid substitution. One missense mutation (E117D) was found in two CSF samples as well as in two control laboratory strains. The other one (A269T) was found in a single CSF sample, and lies within a region corresponding to a functionally essential antigenic site. These are the first mutations of the gene encoding gD of HSV identified in vivo in human encephalitis samples. Overall, the results argue against the role of gD in neurovirulence in humans.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Rozenberg F,Lebon Pdoi
10.3109/13550289609146892subject
Has Abstractpub_date
1996-08-01 00:00:00pages
289-95issue
4eissn
1355-0284issn
1538-2443journal_volume
2pub_type
杂志文章abstract::JC virus (JCV) is an unique virus, but eight different JCV genotypes and various subtypes have been individuated, with a geographic distribution that has been described in general but still needs to be detailed. To define JCV genotype epidemiology in Italy, the authors collected urine from 211 healthy individuals livi...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280390241269
更新日期:2003-10-01 00:00:00
abstract::Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-014-0236-8
更新日期:2014-06-01 00:00:00
abstract::Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases suc...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290049534
更新日期:2002-04-01 00:00:00
abstract::The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490441130
更新日期:2004-06-01 00:00:00
abstract::In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909045382
更新日期:1999-10-01 00:00:00
abstract::Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0388-1
更新日期:2016-04-01 00:00:00
abstract::We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for oth...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0419-y
更新日期:2016-08-01 00:00:00
abstract::Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0271-5
更新日期:2015-06-01 00:00:00
abstract::The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-015-0361-z
更新日期:2015-10-01 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is an inflammatory disease of the spinal cord and clinically characterized by progressive spastic paraparesis, urinary incontinence, and mild sen...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00881-w
更新日期:2020-10-01 00:00:00
abstract::There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00746-x
更新日期:2019-08-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1)-associated neuropathogenesis occurs in a large minority of infected people. Presently, there are neither viral nor cellular markers that predict the development of brain disease during HIV-1 infection. This study was conducted to determine whether there exist systematic diff...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701510104
更新日期:2007-10-01 00:00:00
abstract::HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0279-x
更新日期:2014-12-01 00:00:00
abstract::The neuromotor rehabilitative treatment should be joined in the global individualised project. The rehabilitation project is developed by an interdisciplinary. Hence, the clinicians have to promote an appropriate compensation process in the daily living activities with a rapid insertion of new or recovered motor-postu...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-05-01 00:00:00
abstract::When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280490261716
更新日期:2004-02-01 00:00:00
abstract::The objective of this study was to assess the long-term virological response in cerebrospinal fluid (CSF) in patients treated with highly active antiretroviral therapy (HAART) and to compare this response to CSF and plasma human immunodeficiency virus (HIV) drug resistance profiles. Paired CSF and plasma specimens wer...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/753312753
更新日期:2004-01-01 00:00:00
abstract::The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-018-0688-3
更新日期:2019-02-01 00:00:00
abstract::Rabies is a neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment had severe sequelae. The present study showed that after 48 h of RABV inoculation, mice injected intracerebrally with anti-RABV F (ab')2 plus Bioporter® showed 70% survival compared to the c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00883-8
更新日期:2020-10-01 00:00:00
abstract::Although highly active antiretroviral therapy (HAART) has reduced the incidence of dementia, a significant proportion of HIV-infected individuals cease therapy because of unacceptable side effects. Further, HAART is not available to the majority of HIV-infected people worldwide. Thus, animal models remain an important...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290101076
更新日期:2002-12-01 00:00:00
abstract::Injection drug use has been recognized as a major risk factor for acquired immunodeficiency syndrome (AIDS) from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States, can both impair the functions of macrophages and CD4(+) lymphocytes and also activate human immunodeficiency vi...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701528684
更新日期:2007-12-01 00:00:00
abstract::We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and b...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550281003682539
更新日期:2010-03-01 00:00:00
abstract::Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0221-7
更新日期:2013-12-01 00:00:00
abstract::HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0135-9
更新日期:2013-02-01 00:00:00
abstract::A monocenter observational study was conducted to determine the clinical and virological effects of cidofovir added to highly active anti-retroviral therapy (HAART) in AIDS-associated progressive multifocal leukoencephalopathy (PML). Exposure to other anti-viral drugs or late initiation of cidofovir were exclusion cri...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
doi:10.1080/13550280152537274
更新日期:2001-08-01 00:00:00
abstract::To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590953825
更新日期:2005-07-01 00:00:00
abstract::Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289709015791
更新日期:1997-02-01 00:00:00
abstract::The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0285-z
更新日期:2014-12-01 00:00:00
abstract::Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280152537175
更新日期:2001-08-01 00:00:00
abstract::Although no longer considered therapeutically beneficial, antiretroviral treatment interruptions (TIs) still occur frequently among patients with human immunodeficiency virus (HIV) infection for a variety of reasons. TIs typically result in viral rebound and worsening immunosuppression, which in turn are risk factors ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802372313
更新日期:2008-11-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dement...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-010-0001-6
更新日期:2011-02-01 00:00:00