Abstract：
:Development of multiple sclerosis (MS) is believed to involve genetic as well as environmental factors. A complicating aspect to the study of aetiological factors in MS concerns the possible existence of genetically different subtypes of the disease. In addition, a relatively large number of susceptibility genes could be involved. Most likely, the contribution of the single genes to the susceptibility to MS is modest. However, interactions between different genes could result in a dramatic increase in disease susceptibility (synergistic gene effects). In this short review we focus upon genetic heterogeneity and gene interactions in MS. We also outline approaches to the genetic analysis of complex disease traits such as MS.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Rasmussen HB,Clausen Jsubject
Has Abstractpub_date
2000-05-01 00:00:00pages
S23-7eissn
1355-0284issn
1538-2443journal_volume
6 Suppl 2pub_type
杂志文章,评审abstract：:Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490521131
更新日期：2004-12-01 00:00:00
abstract：:HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-012-0135-9
更新日期：2013-02-01 00:00:00
abstract：:Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0527-y
更新日期：2017-08-01 00:00:00
abstract：:The recent ability to quantitate and localize the interaction of antigen-specific T cells in the central nervous system during infectious and autoimmune diseases will greatly enhance our understanding of the molecular and biologic basis of virus-induced diseases of the nervous and other systems. ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1080/13550280490468438
更新日期：2004-08-01 00:00:00
abstract：:The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289709015807
更新日期：1997-04-01 00:00:00
abstract：:In 2007, the nosology for HIV-1-associated neurocognitive disorders (HAND) was updated to a primarily neurocognitive disorder. However, currently available diagnostic tools lack the sensitivity and specificity needed for an accurate diagnosis for HAND. Scientists and clinicians, therefore, have been on a quest for an ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-018-0705-6
更新日期：2019-10-01 00:00:00
abstract：:The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-014-0285-z
更新日期：2014-12-01 00:00:00
abstract：:The article "Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event," written by Joseph R. Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane3, was originally published electronically on the publisher's internet portal (currently SpringerLink). ...
journal_title：Journal of neurovirology
pub_type： 已发布勘误
doi：10.1007/s13365-018-0637-1
更新日期：2018-06-01 00:00:00
abstract：:The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280500385286
更新日期：2005-12-01 00:00:00
abstract：:Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure E...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00891-8
更新日期：2020-12-01 00:00:00
abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00848-x
更新日期：2020-08-01 00:00:00
abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the neurotropic human polyomavirus JC (JCV) lytic infection of oligodendrocytes. PML was first described as a complication of lymphoproliferative disorders more than 50 years ago and emerged as a major c...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-012-0080-7
更新日期：2012-02-01 00:00:00
abstract：:Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-014-0271-5
更新日期：2015-06-01 00:00:00
abstract：:Rabies is a neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment had severe sequelae. The present study showed that after 48 h of RABV inoculation, mice injected intracerebrally with anti-RABV F (ab')2 plus Bioporter® showed 70% survival compared to the c...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-020-00883-8
更新日期：2020-10-01 00:00:00
abstract：:A method is described for amplification of the complete genome of the human polyomavirus JC (JCV) from progressive multifocal leukuencephalopathy (PML) brain, cerebrospinal fluid (CSF) of PML patients, and from the urine of controls without neurological disease. Efficient amplification with the 'long PCR' method is ac...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509114028
更新日期：1995-09-01 00:00:00
abstract：:We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289709018297
更新日期：1997-06-01 00:00:00
abstract：:Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-018-0614-8
更新日期：2018-06-01 00:00:00
abstract：:Excessive glutamate neurotransmission has been implicated in neuronal injury in many disorders of the central nervous system (CNS), including human immunodeficiency virus (HIV)-associated dementia. Gp120IIIB is a strain of a HIV glycoprotein with specificity for the CXCR4 receptor that induces neuronal apoptosis in in...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550280903350598
更新日期：2009-09-01 00:00:00
abstract：:A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly eleva...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-019-00779-2
更新日期：2020-02-01 00:00:00
abstract：:It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma i...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280152537175
更新日期：2001-08-01 00:00:00
abstract：:We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-018-0717-2
更新日期：2019-06-01 00:00:00
abstract：:Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280802105002
更新日期：2008-05-01 00:00:00
abstract：:Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.3109/13550289509111008
更新日期：1995-03-01 00:00:00
abstract：:The objective of this study was to assess the long-term virological response in cerebrospinal fluid (CSF) in patients treated with highly active antiretroviral therapy (HAART) and to compare this response to CSF and plasma human immunodeficiency virus (HIV) drug resistance profiles. Paired CSF and plasma specimens wer...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/753312753
更新日期：2004-01-01 00:00:00
abstract：:Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infe...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280802400684
更新日期：2009-01-01 00:00:00
abstract：:Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in people living with HIV. This effect was also observed in the central nervous system with the nowadays uncommon observation of dementias; yet in more recent works milder forms are still reported in 20-30% of optimally treated i...
journal_title：Journal of neurovirology
pub_type： 杂志文章,评审
doi：10.1007/s13365-020-00874-9
更新日期：2020-10-01 00:00:00
abstract：:After uniocular anterior chamber (AC) inoculation of herpes simplex virus type 1 (HSV-1), virus and TNF alpha (TNF-alpha) are detected in the suprachiasmatic nuclei (SCN). The goal of this study was to investigate the role of TNF-alpha and macrophages in the brain of HSV-1-infected BALB/c mice. Mice were treated with ...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280601039030
更新日期：2006-12-01 00:00:00
abstract：:Latent infection of sensory neurons and reactivation are necessary for maintenance of herpes simplex virus type 1 (HSV-1) in its host population. It has been proposed that the HSV-1 early gene, thymidine kinase (TK), may play an important regulatory role in this process. The authors used reporter transgenic mice to te...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1080/13550280490279771
更新日期：2004-04-01 00:00:00
abstract：:Subacute sclerosing panencephalitis (SSPE) is a slowly progressive degenerative disorder caused by measles virus. It is characterised by typical clinical and electrophysiological features in the form of slow myoclonic jerks, with progressive cognitive impairment, visual symptoms, and periodic complexes on EEG, with ra...
journal_title：Journal of neurovirology
pub_type： 杂志文章
doi：10.1007/s13365-017-0602-4
更新日期：2018-02-01 00:00:00
