Abstract:
:Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the clearance of central nervous system viral infections has not been explored. Using the Theiler's murine encephalomyelitis virus model, the authors found that NKG2D-positive CD8+ cytotoxic T cells enter the brain, that NKG2D ligands are expressed in the brain during acute infection, and that interruption of NKG2D ligand recognition via treatment with a function-blocking antibody attenuates the efficacy of viral clearance from the central nervous system.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Deb C,Howe CLdoi
10.1080/13550280802105002subject
Has Abstractpub_date
2008-05-01 00:00:00pages
261-6issue
3eissn
1355-0284issn
1538-2443pii
794316006journal_volume
14pub_type
杂志文章abstract::Highly active antiretroviral treatment has led to unprecedented efficacy and tolerability in people living with HIV. This effect was also observed in the central nervous system with the nowadays uncommon observation of dementias; yet in more recent works milder forms are still reported in 20-30% of optimally treated i...
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journal_title:Journal of neurovirology
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更新日期:2010-11-01 00:00:00
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journal_title:Journal of neurovirology
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doi:10.3109/13550289909021298
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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