Viral protein R polymorphisms in the pathogenesis of HIV-associated acute ischaemic stroke: a case-control study.

abstract：:Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

journal_title：Journal of neurovirology

authors： Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

更新日期：2014-08-01 00:00:00

abstract：:Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investiga...

journal_title：Journal of neurovirology

authors： Hay KA,Edris WA,Gaydos A,Tenser RB

更新日期：1998-10-01 00:00:00

abstract：:With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of...

journal_title：Journal of neurovirology

authors： Mondal R,Ganguly U,Deb S,Shome G,Pramanik S,Bandyopadhyay D,Lahiri D

更新日期：2020-12-26 00:00:00

abstract：:Retroviral infection can induce transcriptional activation of genes flanking the sites of proviral integration in target cells. Because integration is essentially random, this phenomenon can be exploited for random mutagenesis of the genome, and analysis of integration sites in tumors may identify potential oncogenes....

journal_title：Journal of neurovirology

authors： Afanasieva TA,Pekarik V,Grazia D'Angelo M,Klein MA,Voigtländer T,Stocking C,Aguzzi A

更新日期：2001-04-01 00:00:00

abstract：:Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

journal_title：Journal of neurovirology

authors： Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

更新日期：1995-03-01 00:00:00

abstract：:Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported t...

journal_title：Journal of neurovirology

authors： Poltermann S,Schlehofer B,Steindorf K,Schnitzler P,Geletneky K,Schlehofer JR

更新日期：2006-04-01 00:00:00

abstract：:Age-dependent poliomyelitis (ADPM) is a virally induced neuroparalytic disease of mice and a model for amyotrophic lateral sclerosis (ALS). ADPM is triggered in genetically susceptible mice by immunosuppression and infection with lactate dehydrogenase-elevating virus (LDV). Both ADPM and ALS are characterized by progr...

journal_title：Journal of neurovirology

authors： Schlenker EH,Jones QA,Rowland RR,Steffen-Bien M,Cafruny WA

更新日期：2001-06-01 00:00:00

abstract：:Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...

journal_title：Journal of neurovirology

authors： Chalermchai T,Valcour V,Sithinamsuwan P,Pinyakorn S,Clifford D,Paul RH,Tipsuk S,Fletcher JL,Degruttola V,Ratto-Kim S,Hutchings N,Shikuma C,Ananworanich J,SEARCH 007 and 011 study groups.

更新日期：2013-04-01 00:00:00

abstract：:Rabies is a neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment had severe sequelae. The present study showed that after 48 h of RABV inoculation, mice injected intracerebrally with anti-RABV F (ab')2 plus Bioporter® showed 70% survival compared to the c...

journal_title：Journal of neurovirology

authors： Agostinho WC,Brandão PE

更新日期：2020-10-01 00:00:00

abstract：:JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...

journal_title：Journal of neurovirology

authors： Eberwein P,Hansen LL,Agostini HT

更新日期：2005-02-01 00:00:00

abstract：:Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...

journal_title：Journal of neurovirology

authors： Deb C,Howe CL

更新日期：2008-05-01 00:00:00

abstract：:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...

journal_title：Journal of neurovirology

authors： Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

更新日期：2016-04-01 00:00:00

abstract：:When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

journal_title：Journal of neurovirology

authors： Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2004-02-01 00:00:00

abstract：:There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...

journal_title：Journal of neurovirology

authors： Mubanga E,Patel A,Siddiqi OK,Hanson BA,Dang X,Lakhi S,Mulundu G,Bender N,Koralnik IJ

更新日期：2019-08-01 00:00:00

abstract：:In the highly active antiretroviral therapy (HAART) era, the role of the inflammatory response in acquired immunodeficiency syndrome (AIDS)-related progressive multifocal leukoencephalopathy (PML) remains controversial. In this study, JC virus DNA load and levels of cytokines were determined in cerebrospinal fluid (CS...

journal_title：Journal of neurovirology

authors： Marzocchetti A,Cingolani A,Giambenedetto SD,Ammassari A,Giancola ML,Cauda R,Antinori A,Luca AD

更新日期：2005-04-01 00:00:00

abstract：:The latency-associated transcript (LAT) is the only herpes simplex virus type 1 (HSV-1) gene that is abundantly transcribed during latency. Plasmids expressing LAT inhibit apoptosis induced by etoposide and ceramide in transiently transfected cells. LAT also inhibits apoptosis in trigeminal ganglia of rabbits and prom...

journal_title：Journal of neurovirology

authors： Henderson G,Peng W,Jin L,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2002-12-01 00:00:00

abstract：:The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...

journal_title：Journal of neurovirology

authors： Canivet C,Uyar O,Rhéaume C,Piret J,Boivin G

更新日期：2019-06-01 00:00:00

abstract：:HIV viral proteins within the central nervous system are associated with the development of neurocognitive impairments in HIV-infected individuals. Dopamine transporter (DAT)-mediated dopamine transport is critical for normal dopamine homeostasis. Abnormal dopaminergic transmission has been implicated as a risk determ...

journal_title：Journal of neurovirology

authors： Zhu J,Yuan Y,Midde NM,Gomez AM,Sun WL,Quizon PM,Zhan CG

更新日期：2016-06-01 00:00:00

abstract：:Our previous studies in an experimental model of rabies showed neuronal process degeneration in association with severe clinical disease. Cultured adult rodent dorsal root ganglion neurons infected with challenge virus standard (CVS)-11 strain of rabies virus (RABV) showed axonal swellings and reduced axonal growth wi...

journal_title：Journal of neurovirology

authors： Kammouni W,Wood H,Saleh A,Appolinario CM,Fernyhough P,Jackson AC

更新日期：2015-08-01 00:00:00

abstract：:Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...

journal_title：Journal of neurovirology

authors： Pérez-Santiago J,De Oliveira MF,Var SR,Day TRC,Woods SP,Gianella S,Mehta SR

更新日期：2017-04-01 00:00:00

abstract：:HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...

journal_title：Journal of neurovirology

authors： Zhu T,Zhong J,Hu R,Tivarus M,Ekholm S,Harezlak J,Ombao H,Navia B,Cohen R,Schifitto G

更新日期：2013-02-01 00:00:00

abstract：:Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...

journal_title：Journal of neurovirology

authors： Cysique LA,Dermody N,Carr A,Brew BJ,Teesson M

更新日期：2016-02-01 00:00:00

abstract：:Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...

journal_title：Journal of neurovirology

authors： Du Pasquier RA,Clark KW,Smith PS,Joseph JT,Mazullo JM,De Girolami U,Letvin NL,Koralnik IJ

更新日期：2001-08-01 00:00:00

abstract：:In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...

journal_title：Journal of neurovirology

authors： Hentzien M,Guihot A,de Maindreville D,Tabary T,Brodard V,Vieillard V,Adle-Biassette H,Bani-Sadr F

更新日期：2020-08-01 00:00:00

abstract：:Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pr...

journal_title：Journal of neurovirology

authors： Heaton RK,Franklin DR,Ellis RJ,McCutchan JA,Letendre SL,Leblanc S,Corkran SH,Duarte NA,Clifford DB,Woods SP,Collier AC,Marra CM,Morgello S,Mindt MR,Taylor MJ,Marcotte TD,Atkinson JH,Wolfson T,Gelman BB,McArthur JC,

更新日期：2011-02-01 00:00:00

abstract：:Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...

journal_title：Journal of neurovirology

authors： Kerr SJ,Armati PJ,Brew BJ

更新日期：1995-12-01 00:00:00

abstract：:The most common complication of zoster in the elderly is postherpetic neuralgia, operationally defined as pain persisting longer than 1-2 months after rash. The cause of postherpetic neuralgia is unknown. Using polymerase chain reaction, we detected varicella zoster virus DNA in blood mononuclear cells from 11 of 51 p...

journal_title：Journal of neurovirology

authors： Mahalingam R,Wellish M,Brucklier J,Gilden DH

更新日期：1995-03-01 00:00:00

abstract：:We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...

journal_title：Journal of neurovirology

authors： Gutierrez J,Murray J,Chon C,Morgello S

更新日期：2018-02-01 00:00:00

abstract：:The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain withou...

journal_title：Journal of neurovirology

authors： Dos Santos DN,Sá KN,Queirós FC,Paixão AB,Santos KOB,de Andrade RCP,Camatti JR,Baptista AF

更新日期：2021-01-06 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...

journal_title：Journal of neurovirology

authors： Ndhlovu LC,Umaki T,Chew GM,Chow DC,Agsalda M,Kallianpur KJ,Paul R,Zhang G,Ho E,Hanks N,Nakamoto B,Shiramizu BT,Shikuma CM

更新日期：2014-12-01 00:00:00