Spectrin: on the path from structure to function.

abstract：:The mitotic spindle assembly and chromosome segregation in eukaryotes must be coordinated with the nuclear envelope (NE) remodeling. In a so-called 'open' mitosis the envelope of the mother nucleus is dismantled allowing the cytoplasmic spindle microtubules to capture the chromosomes. Alternatively, cells undergoing '...

journal_title：Current opinion in cell biology

authors： Zhang D,Oliferenko S

更新日期：2013-02-01 00:00:00

abstract：:Recently, findings regarding a group of cancer predisposition and chromosome instability syndromes, Nijmegen breakage syndrome (NBS), the ataxia-telangiectasia-like disorder (A-TLD) and ataxia telangiectasia have shed light on the unexpected role of recombinational DNA repair proteins in DNA-damage-dependent cell-cycl...

journal_title：Current opinion in cell biology

authors： Petrini JH

更新日期：2000-06-01 00:00:00

abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...

journal_title：Current opinion in cell biology

authors： Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari J

更新日期：2003-08-01 00:00:00

abstract：:The Golgi apparatus occupies a central position within the secretory pathway where it is a hub for vesicle trafficking. Distinct classes of transport vesicles traffic diverse cargoes into and out of this organelle, as well as between the different Golgi subcompartments. A key feature of Golgi trafficking is the specif...

journal_title：Current opinion in cell biology

authors： Witkos TM,Lowe M

更新日期：2017-08-01 00:00:00

abstract：:Mitochondria are highly dynamic organelles that constantly fuse and divide. Dynamin-related GTPases are the core components of the machineries that mediate mitochondrial fusion and fission. The role and regulation of these machineries are currently under intense investigation. Recently, members of the BCL2 family of p...

journal_title：Current opinion in cell biology

authors： Rolland SG,Conradt B

更新日期：2010-12-01 00:00:00

abstract：:The zebrafish is rapidly increasing in popularity with developmental biologists. Driving this interest are the elegant methods for in vivo observations and recovery of early developmental mutations. The past year has seen the introduction of additional methods for in vivo manipulation of identified cells and the appli...

journal_title：Current opinion in cell biology

authors： Fulwiler C,Gilbert W

更新日期：1991-12-01 00:00:00

abstract：:Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that c...

journal_title：Current opinion in cell biology

authors： Parise LV

更新日期：1999-10-01 00:00:00

abstract：:Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine ...

journal_title：Current opinion in cell biology

authors： Schaller MD,Parsons JT

更新日期：1994-10-01 00:00:00

abstract：:Receptors for the two peroxisomal targeting signals PTS1 and PTS2 have recently been identified in yeasts. The disparate subcellular locations of PTS receptor homologs have led to proposals of receptor shuttling between the cytosol and the peroxisomal membrane, and to the suggestion that some of these molecules may ev...

journal_title：Current opinion in cell biology

authors： Subramani S

更新日期：1996-08-01 00:00:00

abstract：:Oocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown....

journal_title：Current opinion in cell biology

authors： Kang YK,Lee KK,Han YM

更新日期：2003-06-01 00:00:00

abstract：:The initiation of chromosomal DNA replication involves initiator proteins that recruit and load hexameric DNA helicases at replication origins. This helicase loading step is tightly regulated in bacteria and eukaryotes. In contrast to the situation in bacteria, the eukaryotic helicase is loaded in an inactive form. Th...

journal_title：Current opinion in cell biology

authors： Remus D,Diffley JF

更新日期：2009-12-01 00:00:00

abstract：:Regulation of skeletal muscle determination and differentiation in vertebrates centers on a core regulatory network which is composed of two families of transcription factors, the MyoD group basic helix-loop-helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regula...

journal_title：Current opinion in cell biology

authors： Yun K,Wold B

更新日期：1996-12-01 00:00:00

abstract：:Evolution of the mammalian sex chromosomes heavily impacts on the expression of X-encoded genes, both in marsupials and placental mammals. The loss of genes from the Y chromosome forced a two-fold upregulation of dose sensitive X-linked homologues. As a corollary, female cells would experience a lethal dose of X-linke...

journal_title：Current opinion in cell biology

authors： Gribnau J,Grootegoed JA

更新日期：2012-06-01 00:00:00

abstract：:AB toxins deliver their enzymatically active A domain to the cytosol. Some AB-toxins are able to penetrate cellular membranes from endosomes where the low pH triggers their translocation. One such toxin is diphtheria toxin and important features of its translocation mechanism have been unraveled during the last year. ...

journal_title：Current opinion in cell biology

authors： Falnes PO,Sandvig K

更新日期：2000-08-01 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau pro...

journal_title：Current opinion in cell biology

authors： Semenza GL

更新日期：2001-04-01 00:00:00

abstract：:Several proteins involved in exocytosis have been identified recently, but it is still completely unclear which molecules perform the fusion event itself. Although in viral fusion the fusion proteins are known, even there the molecular mechanism remains controversial. Investigation of single fusion events by electroph...

journal_title：Current opinion in cell biology

authors： Lindau M,Almers W

更新日期：1995-08-01 00:00:00

abstract：:The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place th...

journal_title：Current opinion in cell biology

authors： Yonemura S

更新日期：2011-10-01 00:00:00

abstract：:The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including ...

journal_title：Current opinion in cell biology

authors： Ferretti E,Hadjantonakis AK

更新日期：2019-12-01 00:00:00

abstract：:Over the last five decades more than 100 types of RNA modifications have been identified in organism of all kingdoms of life, yet their function and biological relevance remain largely elusive. The recent development of transcriptome-wide techniques to detect RNA modifications such as N(6)-methyladenosine (m(6)A) and ...

journal_title：Current opinion in cell biology

authors： Blanco S,Frye M

更新日期：2014-12-01 00:00:00

abstract：:In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including cancer. The role of adhesion molecules, especially integrins, in pathological angiogenesis has long been the subject of investigation, mostly because of their potenti...

journal_title：Current opinion in cell biology

authors： Hodivala-Dilke K

更新日期：2008-10-01 00:00:00

abstract：:Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are ...

journal_title：Current opinion in cell biology

authors： Verhey KJ,Yang W

更新日期：2016-08-01 00:00:00

abstract：:Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through th...

journal_title：Current opinion in cell biology

authors： Planas-Silva MD,Weinberg RA

更新日期：1997-12-01 00:00:00

abstract：:The structure of mitochondria is highly dynamic. Mitochondrial shape is cell-type specific and can be modified to meet changing requirements in energy production, calcium homeostasis, lipid biogenesis, fatty acid synthesis and other mitochondrial activities. This is achieved by modulating the dynamic properties of mit...

journal_title：Current opinion in cell biology

authors： Hoppins S

更新日期：2014-08-01 00:00:00

abstract：:Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigeneti...

journal_title：Current opinion in cell biology

authors： Peng JC,Lin H

更新日期：2013-04-01 00:00:00

abstract：:The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...

journal_title：Current opinion in cell biology

authors： Doyle AD,Petrie RJ,Kutys ML,Yamada KM

更新日期：2013-10-01 00:00:00

abstract：:The rate at which receptors have been cloned has recently increased dramatically--existing families have been extended and new families created. The rapid cloning by homology of 'orphan receptors' has also stimulated the development of a new reverse pharmacology. ...

journal_title：Current opinion in cell biology

authors： Libert F,Vassart G,Parmentier M

更新日期：1991-04-01 00:00:00

abstract：:The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become ...

journal_title：Current opinion in cell biology

authors： Hastings ML,Krainer AR

更新日期：2001-06-01 00:00:00

abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...

journal_title：Current opinion in cell biology

authors： Shaw TJ,Martin P

更新日期：2016-10-01 00:00:00

abstract：:Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cov...

journal_title：Current opinion in cell biology

authors： Bigas A,Espinosa L

更新日期：2018-12-01 00:00:00

abstract：:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word. ...

journal_title：Current opinion in cell biology

authors： Brown NH

更新日期：2000-10-01 00:00:00