Abstract:
:Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are indeed a bona fide organelle with a unique protein and lipid content that enables specific cellular functions. Despite the physiological and clinical relevance of cilia, our understanding of how a unique protein and lipid composition is generated for this organelle remains poor. Here we review recent work on the mechanisms that determine the protein and lipid content, and thus the functional outputs, of this unique organelle.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Verhey KJ,Yang Wdoi
10.1016/j.ceb.2016.05.004subject
Has Abstractpub_date
2016-08-01 00:00:00pages
109-16eissn
0955-0674issn
1879-0410pii
S0955-0674(16)30090-4journal_volume
41pub_type
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:1998-02-01 00:00:00
abstract::The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
abstract::The initiation of chromosomal DNA replication involves initiator proteins that recruit and load hexameric DNA helicases at replication origins. This helicase loading step is tightly regulated in bacteria and eukaryotes. In contrast to the situation in bacteria, the eukaryotic helicase is loaded in an inactive form. Th...
journal_title:Current opinion in cell biology
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abstract::Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau pro...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(00)00194-0
更新日期:2001-04-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2006.06.011
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abstract::How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell divisio...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2012.10.001
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abstract::Recently there have been advances in studies of the molecular biology of the receptor for CNTF. In contrast with the receptors for other known neurotrophic factors, which belong to the family of receptor tyrosine kinases, the CNTF receptor belongs to the family of cytokine receptors. This review will describe the stru...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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abstract::The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2013.04.001
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abstract::The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place th...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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更新日期:2003-04-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::The relationship between cell growth (cell mass increase over time) and cell division is poorly understood in animal stem cells. Recent studies in several Drosophila stem cell types have provided the tools to interrogate this relationship. In several cases (brat, mei-P26, pros, bam, lethal giant larvae, polo), mutatio...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00